PMID- 31208781
OWN - NLM
STAT- MEDLINE
DCOM- 20200521
LR  - 20210224
IS  - 1097-6833 (Electronic)
IS  - 0022-3476 (Print)
IS  - 0022-3476 (Linking)
VI  - 212
DP  - 2019 Sep
TI  - Gastroenteritis, Hepatitis, Encephalopathy, and Human Herpesvirus 6 Detection in 
      an Immunocompetent Child: Benefits and Risks of Syndromic Multiplex Molecular 
      Panel Testing.
PG  - 228-231
LID - S0022-3476(19)30541-4 [pii]
LID - 10.1016/j.jpeds.2019.04.058 [doi]
AB  - An immunocompetent toddler came to medication attention with gastroenteritis, 
      complicated by encephalopathy and hepatitis. Multiplexed testing using a 
      polymerase chain reaction meningitis panel was positive for human herpesvirus 6 
      (HHV-6). Clinical correlation, quantitative HHV-6 polymerase chain reaction, and 
      metagenomic next-generation sequencing supported a likely diagnosis of primary 
      HHV-6B infection.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Olson, Christina A
AU  - Olson CA
AD  - Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO; 
      Children's Hospital Colorado, Aurora, CO. Electronic address: 
      Christina.olson@childrenscolorado.org.
FAU - Dominguez, Samuel R
AU  - Dominguez SR
AD  - Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO; 
      Children's Hospital Colorado, Aurora, CO.
FAU - Miller, Steve
AU  - Miller S
AD  - Department of Laboratory Medicine, University of California San Francisco, San 
      Francisco, CA.
FAU - Chiu, Charles Y
AU  - Chiu CY
AD  - Department of Laboratory Medicine, University of California San Francisco, San 
      Francisco, CA; University of California San Francisco-Abbott Laboratories Viral 
      Diagnostics and Discovery Center, San Francisco, CA; Division of Infectious 
      Diseases, Department of Medicine, University of California San Francisco, San 
      Francisco, CA.
FAU - Messacar, Kevin
AU  - Messacar K
AD  - Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO; 
      Children's Hospital Colorado, Aurora, CO.
LA  - eng
GR  - K23 AI128069/AI/NIAID NIH HHS/United States
GR  - UL1 TR002535/TR/NCATS NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190614
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
SB  - IM
MH  - Brain Diseases/*virology
MH  - Exanthema Subitum/*virology
MH  - Gastroenteritis/*virology
MH  - Hepatitis/*virology
MH  - Herpesvirus 6, Human/genetics/*isolation & purification
MH  - Humans
MH  - Immunocompetence
MH  - Infant
MH  - Male
MH  - *Multiplex Polymerase Chain Reaction
MH  - Risk Assessment
PMC - PMC6707859
MID - NIHMS1528603
OTO - NOTNLM
OT  - BioFire FilmArray
OT  - HHV-6
OT  - roseola
EDAT- 2019/06/19 06:00
MHDA- 2020/05/22 06:00
PMCR- 2019/06/14
CRDT- 2019/06/19 06:00
PHST- 2019/01/12 00:00 [received]
PHST- 2019/04/23 00:00 [revised]
PHST- 2019/04/28 00:00 [accepted]
PHST- 2019/06/19 06:00 [pubmed]
PHST- 2020/05/22 06:00 [medline]
PHST- 2019/06/19 06:00 [entrez]
PHST- 2019/06/14 00:00 [pmc-release]
AID - S0022-3476(19)30541-4 [pii]
AID - 10.1016/j.jpeds.2019.04.058 [doi]
PST - ppublish
SO  - J Pediatr. 2019 Sep;212:228-231. doi: 10.1016/j.jpeds.2019.04.058. Epub 2019 Jun 
      14.