PMID- 31209190
OWN - NLM
STAT- MEDLINE
DCOM- 20200102
LR  - 20200102
IS  - 1735-8604 (Electronic)
IS  - 1735-8582 (Linking)
VI  - 13
IP  - 3
DP  - 2019 May
TI  - Levels and Clinical Significances of Glypican-5 in Urine of Type 2 Diabetic 
      Nephropathy Cases.
PG  - 173-181
AB  - INTRODUCTION: Increased glypican-5 expression in podocytes induces podocyte 
      injury. Glypican-5 is shed into the urine, but its value in predicting 
      progression of diabetic nephropathy (DN) has not been investigated. METHODS: 
      Glypican-5 was determined in spot urine from 20 type 2 diabetes mellitus (T2DM) 
      patients, and 37 type 2 DN patients, and 20 healthy controls by enzyme-linked 
      immunosorbent assay. The association of urinary glypican-5 with markers of renal 
      function was evaluated. RESULTS: Urinary glypican-5 was significantly higher in 
      DN patients than in both DM patients and controls. Glypican-5 level was not 
      associated with baseline 24-hour urine protein/albumin excretion, serum 
      creatinine, estimated glomerular filtration rate (eGFR), systolic blood pressure 
      (SBP), or hemoglobin (Hb) A1c values in the DN patients. After 52 weeks 
      follow-up, urinary glypican-5 level was associated with significant increases in 
      urine protein and albumin excretion and a significant decline in eGFR in the DN 
      patients. The decline in eGFR was independent of changes in urine protein and 
      albumin excretion, SBP, or HbA1c. The results indicate that urinary glypican-5 
      was not only a biomarker but also contributed to the pathogenesis of DN in these 
      patients. CONCLUSION: Urinary glypican-5 was specifically elevated in type 2 
      diabetes patients with DN and it was associated with disease progression. Urinary 
      glypican-5 may serve as a useful non-invasive marker for the progression of DN.
FAU - Li, Ruizhao
AU  - Li R
FAU - Zhang, Li
AU  - Zhang L
FAU - Zhang, Shu
AU  - Zhang S
FAU - Yang, Huan
AU  - Yang H
FAU - Yao, Bingfeng
AU  - Yao B
FAU - Dong, Wei
AU  - Dong W
FAU - Zhang, Bin
AU  - Zhang B
FAU - Chen, Yuanhan
AU  - Chen Y
FAU - Liu, Shuangxin
AU  - Liu S
FAU - Zhao, Xingchen
AU  - Zhao X
FAU - Zhang, Qianmei
AU  - Zhang Q
FAU - Shi, Wei
AU  - Shi W
FAU - Liang, Xinling
AU  - Liang X
AD  - Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy 
      of Medical Sciences, Guangzhou, China. xinlingliang_ggh@163.com.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Kidney Dis
JT  - Iranian journal of kidney diseases
JID - 101316967
RN  - 0 (Biomarkers)
RN  - 0 (Glypicans)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Albuminuria
MH  - Biomarkers/urine
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*urine
MH  - Diabetic Nephropathies/*urine
MH  - Disease Progression
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Glypicans/*urine
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2019/06/19 06:00
MHDA- 2020/01/03 06:00
CRDT- 2019/06/19 06:00
PHST- 2018/08/01 00:00 [received]
PHST- 2018/11/04 00:00 [accepted]
PHST- 2019/06/19 06:00 [entrez]
PHST- 2019/06/19 06:00 [pubmed]
PHST- 2020/01/03 06:00 [medline]
AID - 4161/1065 [pii]
PST - ppublish
SO  - Iran J Kidney Dis. 2019 May;13(3):173-181.