PMID- 31209490
OWN - NLM
STAT- MEDLINE
DCOM- 20200406
LR  - 20230216
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Linking)
VI  - 149
IP  - 8
DP  - 2019 Aug 1
TI  - Joint Analysis of Metabolite Markers of Fish Intake and Persistent Organic 
      Pollutants in Relation to Type 2 Diabetes Risk in Swedish Adults.
PG  - 1413-1423
LID - 10.1093/jn/nxz068 [doi]
AB  - BACKGROUND: There is conflicting evidence regarding the association between fish 
      intake and type 2 diabetes (T2D) incidence, possibly owing to measurement errors 
      in self-reported intake and coexposure to persistent organic pollutants (POPs) 
      present in fish. OBJECTIVE: The aim of this study was to identify plasma 
      metabolites associated with fish intake and to assess their association with T2D 
      risk, independently of POPs, in Swedish adults. METHODS: In a case-control study 
      nested in the Swedish Vasterbotten Intervention Programme, fasting plasma samples 
      from 421 matched T2D case-control pairs of men and women aged 30-60 y at baseline 
      and 10-y follow-up samples from a subset of 149 pairs were analyzed using 
      untargeted metabolomics. Moreover, 16 plasma POPs were analyzed for the 149 pairs 
      who had repeated samples available. Fish-related plasma metabolites were 
      identified using multivariate modelling and partial correlation analysis. 
      Reproducibility of metabolites and metabolite patterns, derived via principal 
      component analysis (PCA), was assessed by intraclass correlation. A unique 
      component of metabolites unrelated to POPs was dissected by integrating 
      metabolites and POPs using 2-way orthogonal partial least squares regression. ORs 
      of T2D were estimated using conditional logistic regression. RESULTS: We 
      identified 31 metabolites associated with fish intake that had poor to good 
      reproducibility. A PCA-derived metabolite pattern strongly correlated with fish 
      intake (rho = 0.37, P < 0.001) but showed no association with T2D risk. Integrating 
      fish-related metabolites and POPs led to a unique metabolite component 
      independent of POPs, which tended to be inversely associated with T2D risk (OR: 
      0.75; 95% CI: 0.54, 1.02, P = 0.07). This component mainly consisted of 
      metabolites reflecting fatty fish intake. CONCLUSIONS: Our results suggest that 
      fatty fish intake may be beneficial for T2D prevention, after removing the 
      counteractive effects of coexposure to POPs in Swedish adults. Integrating 
      metabolite markers and POP exposures appears a promising approach to advance the 
      understanding of associations between fish intake and T2D incidence.
CI  - Copyright (c) American Society for Nutrition 2019.
FAU - Shi, Lin
AU  - Shi L
AD  - Department of Biology and Biological Engineering, Chalmers University of 
      Technology, Gothenburg, Sweden.
FAU - Brunius, Carl
AU  - Brunius C
AD  - Department of Biology and Biological Engineering, Chalmers University of 
      Technology, Gothenburg, Sweden.
FAU - Bergdahl, Ingvar A
AU  - Bergdahl IA
AD  - Department of Biobank Research.
AD  - Department of Public Health and Clinical Medicine.
FAU - Johansson, Ingegerd
AU  - Johansson I
AD  - Department of Odontology, Umea University, Umea, Sweden.
FAU - Rolandsson, Olov
AU  - Rolandsson O
AD  - Department of Public Health and Clinical Medicine.
FAU - Donat Vargas, Carolina
AU  - Donat Vargas C
AD  - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
FAU - Kiviranta, Hannu
AU  - Kiviranta H
AD  - Environmental Health Unit, National Institute for Health and Welfare, Kuopio, 
      Finland.
FAU - Hanhineva, Kati
AU  - Hanhineva K
AD  - LC-MS Metabolomics Center, Kuopio, Finland.
AD  - Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
FAU - Akesson, Agneta
AU  - Akesson A
AD  - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
FAU - Landberg, Rikard
AU  - Landberg R
AD  - Department of Biology and Biological Engineering, Chalmers University of 
      Technology, Gothenburg, Sweden.
AD  - Department of Public Health and Clinical Medicine.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Biomarkers)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Diabetes Mellitus, Type 2/blood/*epidemiology
MH  - *Diet
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Seafood
MH  - Sweden/epidemiology
MH  - Water Pollutants, Chemical/*blood
OTO - NOTNLM
OT  - O2PLS modeling
OT  - fish biomarkers
OT  - metabolomics
OT  - nested case-control study
OT  - persistent organic pollutants
OT  - type 2 diabetes
EDAT- 2019/06/19 06:00
MHDA- 2020/04/09 06:00
CRDT- 2019/06/19 06:00
PHST- 2019/01/08 00:00 [received]
PHST- 2019/02/13 00:00 [revised]
PHST- 2019/03/20 00:00 [accepted]
PHST- 2019/06/19 06:00 [pubmed]
PHST- 2020/04/09 06:00 [medline]
PHST- 2019/06/19 06:00 [entrez]
AID - S0022-3166(22)16686-1 [pii]
AID - 10.1093/jn/nxz068 [doi]
PST - ppublish
SO  - J Nutr. 2019 Aug 1;149(8):1413-1423. doi: 10.1093/jn/nxz068.