PMID- 31210172
OWN - NLM
STAT- MEDLINE
DCOM- 20200116
LR  - 20200225
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 25
DP  - 2019 Jun 18
TI  - A Retrospective Study of The Prognostic Significance of Preoperative Plasma 
      Fibrinogen, Mean Platelet Volume, and the Neutrophil-to-Lymphocyte Ratio in 
      Patients with Laryngeal Squamous Cell Carcinoma.
PG  - 4527-4534
LID - 10.12659/MSM.914426 [doi]
AB  - BACKGROUND This study aimed to evaluate the prognostic significance of plasma 
      fibrinogen, serum albumin, the mean platelet volume (MPV), and the 
      neutrophil-to-lymphocyte ratio (NLR) in patients with laryngeal squamous cell 
      carcinoma (LSCC) who underwent surgical resection. MATERIAL AND METHODS A 
      retrospective study included 110 patients with LSCC who underwent surgical 
      resection between January 2008 to June 2015. Clinicopathologic and demographic 
      data were recorded. Preoperative levels of plasma fibrinogen, serum albumin, MPV, 
      and NLR were measured, and all patients underwent postoperative follow-up. The 
      Kaplan-Meier method was used to determine the impact of these factors on overall 
      survival (OS) and disease-free survival (DFS). RESULTS Preoperative 
      hyperfibrinogenemia was significantly correlated with clinical stage, T stage, 
      and tumor location in patients with LSCC (P<0.05). Serum albumin, MPV, and NLR 
      were significantly correlated with the clinical stage and the T stage (P<0.05). 
      The OS and DFS were significantly reduced in patients with hyperfibrinogenemia 
      compared with patients with plasma fibrinogen <4 g/dL (P<0.05). Serum albumin of 
      35 g/L was not significantly correlated with OS (P>0.05). Patients with an MPV 
      <9.5 fL had a significantly longer OS compared with patients with an MPV >/=9.5 fL 
      (P=0.026). The DFS of patients with an NLR <2.22 was significantly longer than 
      for those with an NLR >/=2.22. CONCLUSIONS Preoperative hyperfibrinogenemia, 
      increased MPV and NLR were associated with reduced prognosis in patients with 
      LSCC.
FAU - Sheng, Xiaoli
AU  - Sheng X
AD  - Department of Otorhinolaryngology, Guangdong Provincial Peoples' Hospital and 
      Guangdong Acadamy of Medical Sciences, Guangzhou, Guangdong, China (mainland).
AD  - Southern Medical University, Guangzhou, Guangdong, China (mainland).
FAU - Zhang, Heng
AU  - Zhang H
AD  - State Key Laboratory of Respiratory Disease, Department of Pathology, First 
      Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China 
      (mainland).
FAU - Ge, Pingjiang
AU  - Ge P
AD  - Department of Otorhinolaryngology, Guangdong Provincial Peoples' Hospital and 
      Guangdong Acadamy of Medical Sciences, Guangzhou, Guangdong, China (mainland).
AD  - Southern Medical University, Guangzhou, Guangdong, China (mainland).
FAU - Chen, Liangsi
AU  - Chen L
AD  - Department of Otorhinolaryngology, Guangdong Provincial Peoples' Hospital and 
      Guangdong Acadamy of Medical Sciences, Guangzhou, Guangdong, China (mainland).
AD  - Southern Medical University, Guangzhou, Guangdong, China (mainland).
FAU - Zhang, Siyi
AU  - Zhang S
AD  - Department of Otorhinolaryngology, Guangdong Provincial Peoples' Hospital and 
      Guangdong Acadamy of Medical Sciences, Guangzhou, Guangdong, China (mainland).
AD  - Southern Medical University, Guangzhou, Guangdong, China (mainland).
LA  - eng
PT  - Journal Article
DEP - 20190618
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (Biomarkers)
RN  - 0 (Hemostatics)
RN  - 9001-32-5 (Fibrinogen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Carcinoma, Squamous Cell/mortality/*pathology
MH  - Disease-Free Survival
MH  - Female
MH  - Fibrinogen/analysis
MH  - Hemostatics
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/*mortality/*pathology
MH  - Lymphocytes/pathology
MH  - Male
MH  - Mean Platelet Volume
MH  - Middle Aged
MH  - Neutrophils/pathology
MH  - Preoperative Period
MH  - Prognosis
MH  - Retrospective Studies
PMC - PMC6597139
EDAT- 2019/06/19 06:00
MHDA- 2020/01/17 06:00
PMCR- 2019/06/18
CRDT- 2019/06/19 06:00
PHST- 2019/06/19 06:00 [entrez]
PHST- 2019/06/19 06:00 [pubmed]
PHST- 2020/01/17 06:00 [medline]
PHST- 2019/06/18 00:00 [pmc-release]
AID - 914426 [pii]
AID - 10.12659/MSM.914426 [doi]
PST - epublish
SO  - Med Sci Monit. 2019 Jun 18;25:4527-4534. doi: 10.12659/MSM.914426.