PMID- 31210899
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2008-384X (Print)
IS  - 2252-0058 (Electronic)
IS  - 2008-384X (Linking)
VI  - 17
IP  - 4
DP  - 2018 Oct 7
TI  - Association of human leukocyte antigen-DRB haplotype in multiple sclerosis 
      population of Khuzestan, Iran.
PG  - 154-160
AB  - Background: One of the demyelinating and inflammatory diseases of the central 
      nervous system (CNS) is multiple sclerosis (MS). Though pathogenesis of MS is 
      still unknown, both genetic and environmental factors are involved. The human 
      leukocyte antigen (HLA) class-II alleles including HLA-DRB5*01, DQB1*0602, 
      DRB1*1501, and DQA1*0102 may have remarkable effect in MS risk although it is 
      controversial in studies. As there is no data with respect to the 
      HLA-DRB1*1501-DRB5*01 correlation with MS in Khuzestan Province, Iran, the goal 
      of the survey was to investigate the association of this haplotype with MS in 
      this population. Methods: The study focused on DRB5*01-DRB1*1501 haplotype 
      association with MS in 200 patients and 200 healthy individuals. Typing of HLA 
      was carried out by polymerase chain reaction (PCR) amplification with 
      sequence-specific primers (SSP) method. SPSS software was used for the 
      statistical analyses. Results: No association between DRB5*01(+)-DRB1*1501(+) and 
      MS was found (P = 0.156). Distribution of DRB1*1501(+)-DRB5*01(-) (carrying 
      DRB1*1501(+) but not DRB5*01(-)) and DRB1*1501(-)-DRB5*01(-) haplotypes was 
      statistically different between patients and controls (29.73% vs. 11.81%, P < 
      0.001) and (42.16% vs. 68.50%, P < 0.001), respectively. However, 
      DRB1*1501(-)-DRB5*01(+) revealed no association with MS (15.13% vs. 11.81%, P = 
      0.403). HLA-DRB1*1501(-)-DRB5*01(+) was signi fi cantly more frequent among female 
      patients with MS (16.19% vs. 6.12%, P = 0.019) and Persian group (17.11% vs. 
      5.79%, P = 0.027). Positive correlation of HLA-DRB1*1501(+)-DRB5*01(-) haplotype 
      with the expanded disability status scale (EDSS) steps from 5 to 10 was observed 
      (62.50% vs. 25.76%, P = 0.026). Moreover, no meaningful association was shown 
      among the haplotypes with EDSS, course of MS, ethnicity, and gender. Conclusion: 
      Our findings suggest that DRB1*1501(+)-DRB5*01(-) and DRB1*1501(-)-DRB5*01(-) 
      haplotypes may have positive association with MS risk. Also, this survey 
      indicates that HLA-DRB1*1501(-)-DRB5*01(+) is involved in susceptibility of the 
      disease among women and Persians. DRB1*1501(+)-DRB5*01(-) genotype frequency may 
      have a key role in MS developing.
FAU - Delfan, Nooshin
AU  - Delfan N
AD  - Department of Genetics, School of Sciences, Shahid Chamran University of Ahvaz, 
      Ahvaz, Iran.
FAU - Galehdari, Hamid
AU  - Galehdari H
AD  - Department of Genetics, School of Sciences, Shahid Chamran University of Ahvaz, 
      Ahvaz, Iran.
FAU - Shafiei, Mohammad
AU  - Shafiei M
AD  - Department of Genetics, School of Sciences, Shahid Chamran University of Ahvaz, 
      Ahvaz, Iran.
FAU - Ghanbari-Mardasi, Farideh
AU  - Ghanbari-Mardasi F
AD  - Department of Genetics, School of Sciences, Shahid Chamran University of Ahvaz, 
      Ahvaz, Iran.
FAU - Latifi, Tahereh
AU  - Latifi T
AD  - Department of Genetics, School of Sciences, Shahid Chamran University of Ahvaz, 
      Ahvaz, Iran.
FAU - Majdinasab, Nastaran
AU  - Majdinasab N
AD  - Multiple Sclerosis Society, School of Rehabilitation, Ahvaz Jundishapur 
      University of Medical Sciences, Ahvaz, Iran.
FAU - Seifi, Tahereh
AU  - Seifi T
AD  - Department of Genetics, School of Sciences, Shahid Chamran University of Ahvaz, 
      Ahvaz, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Neurol
JT  - Iranian journal of neurology
JID - 101589458
PMC - PMC6555884
OTO - NOTNLM
OT  - Human Leukocyte Antigen-DRB1*1501
OT  - Human Leukocyte Antigen-DRB5
OT  - Iran
OT  - Multiple Sclerosis
OT  - Polymerase Chain Reaction
EDAT- 2019/06/19 06:00
MHDA- 2019/06/19 06:01
PMCR- 2018/10/07
CRDT- 2019/06/19 06:00
PHST- 2019/06/19 06:00 [entrez]
PHST- 2019/06/19 06:00 [pubmed]
PHST- 2019/06/19 06:01 [medline]
PHST- 2018/10/07 00:00 [pmc-release]
AID - IJNL-17-154 [pii]
PST - ppublish
SO  - Iran J Neurol. 2018 Oct 7;17(4):154-160.