PMID- 31211520
OWN - NLM
STAT- MEDLINE
DCOM- 20200819
LR  - 20200819
IS  - 2192-2659 (Electronic)
IS  - 2192-2640 (Linking)
VI  - 8
IP  - 15
DP  - 2019 Aug
TI  - pH-Triggered Conformational Change of Antp-Based Drug Delivery Platform for Tumor 
      Treatment with Combined Photothermal Therapy and Chemotherapy.
PG  - e1900306
LID - 10.1002/adhm.201900306 [doi]
AB  - Poor cellular uptake and low therapeutic efficacy of small-molecule antitumor 
      drugs limit the application of drug delivery systems (DDSs) in cancer therapy. A 
      conformational change of the Antp mimetic peptide (AMP) in tumor 
      microenvironments can greatly increase the cellular uptake as well as control 
      drug release from a DDS. In this study, AMP-based nanoparticles (AMP-NPs) 
      conjugated with tyroserleutide (YSL), an immunologically therapeutic tripeptide, 
      are designed to encapsulate doxorubicin (Dox) and indocyanine green (ICG) to 
      improve cellular uptake and cancer therapeutic efficacy by combining chemotherapy 
      with photothermal therapy. In vitro studies verify that AMP-NPs can control the 
      release of Dox and YSL at different pH values. Cell experiments show that AMP-NPs 
      can promote the cellular uptake of Dox, and YSL can promote hepatocarcinoma cell 
      (H22) apoptosis through downregulating Bcl-2 and cyclin D1 expression. In a mouse 
      xenograft model using H22 cells, tumors are ablated when Dox- and ICG-loaded 
      AMP-NPs are injected with the combination of hyperthermia effect induced by 
      near-infrared (NIR) laser irradiation and chemotherapy from Dox and YSL. The pH-, 
      photothermal-, and glutathione-responsive AMP-NPs with a conformational 
      transition strategy can be utilized to synergistically enhance the cancer 
      therapeutic efficacy with few side effects upon NIR laser irradiation.
CI  - (c) 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Liang, Peiqing
AU  - Liang P
AD  - Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical 
      Instruments (Sun Yat-sen University), School of Biomedical Engineering, Sun 
      Yat-sen University, Guangzhou, 510006, P. R. China.
FAU - Wang, Mohong
AU  - Wang M
AD  - Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical 
      Instruments (Sun Yat-sen University), School of Biomedical Engineering, Sun 
      Yat-sen University, Guangzhou, 510006, P. R. China.
FAU - Zhang, Shixiong
AU  - Zhang S
AD  - Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical 
      Instruments (Sun Yat-sen University), School of Biomedical Engineering, Sun 
      Yat-sen University, Guangzhou, 510006, P. R. China.
FAU - Wang, Jiayu
AU  - Wang J
AD  - Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical 
      Instruments (Sun Yat-sen University), School of Biomedical Engineering, Sun 
      Yat-sen University, Guangzhou, 510006, P. R. China.
FAU - Dai, Chunlei
AU  - Dai C
AD  - Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical 
      Instruments (Sun Yat-sen University), School of Biomedical Engineering, Sun 
      Yat-sen University, Guangzhou, 510006, P. R. China.
FAU - Quan, Changyun
AU  - Quan C
AUID- ORCID: 0000-0001-9934-5348
AD  - Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical 
      Instruments (Sun Yat-sen University), School of Biomedical Engineering, Sun 
      Yat-sen University, Guangzhou, 510006, P. R. China.
LA  - eng
GR  - 201804010146/Science and Technology Program of Guangzhou, China/International
GR  - 2016A030313341/Natural Science Foundation of Guangdong Province/International
GR  - 2014B020215001/Science and Technology Planning Project of Guangdong Province, 
      China/International
GR  - 2016A030313341/Natural Science Foundation of Guangdong Province, 
      China/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190618
PL  - Germany
TA  - Adv Healthc Mater
JT  - Advanced healthcare materials
JID - 101581613
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Antimicrobial Cationic Peptides)
RN  - 0 (Drug Carriers)
RN  - 0 (Oligopeptides)
RN  - 80168379AG (Doxorubicin)
RN  - IX6J1063HV (Indocyanine Green)
RN  - L9TIM50J8N (H-Tyr-Ser-Leu-OH)
SB  - IM
MH  - Animals
MH  - Antibiotics, Antineoplastic/chemistry/pharmacology
MH  - Antimicrobial Cationic Peptides/*chemistry
MH  - Apoptosis/drug effects
MH  - Cell Line, Tumor
MH  - Doxorubicin/chemistry/metabolism/pharmacology
MH  - Drug Carriers/*chemistry
MH  - Drug Liberation
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Indocyanine Green/chemistry/metabolism/pharmacology
MH  - Infrared Rays
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Nanoparticles/*chemistry/metabolism
MH  - Neoplasms/drug therapy/therapy
MH  - Oligopeptides/chemistry
MH  - Phototherapy
MH  - Tissue Distribution
OTO - NOTNLM
OT  - Antp mimetic peptide
OT  - antitumor efficacy
OT  - chemo/photothermal therapy
OT  - tyroserleutide
EDAT- 2019/06/19 06:00
MHDA- 2020/08/20 06:00
CRDT- 2019/06/19 06:00
PHST- 2019/03/09 00:00 [received]
PHST- 2019/05/28 00:00 [revised]
PHST- 2019/06/19 06:00 [pubmed]
PHST- 2020/08/20 06:00 [medline]
PHST- 2019/06/19 06:00 [entrez]
AID - 10.1002/adhm.201900306 [doi]
PST - ppublish
SO  - Adv Healthc Mater. 2019 Aug;8(15):e1900306. doi: 10.1002/adhm.201900306. Epub 
      2019 Jun 18.