PMID- 31212185
OWN - NLM
STAT- MEDLINE
DCOM- 20190827
LR  - 20191029
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 181
DP  - 2019 Oct 15
TI  - Toxic effects of 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal on the 
      maturation and subsequent development of murine oocyte.
PG  - 370-380
LID - S0147-6513(19)30634-7 [pii]
LID - 10.1016/j.ecoenv.2019.06.006 [doi]
AB  - Cigarette smoke can cause follicle destruction and oocyte dysfunction and 
      increase the risks of spontaneous abortion, stillbirth, and tubal ectopic 
      pregnancy, affecting female reproductive health. Third-hand smoke (THS) is 
      residual tobacco smoke existing in the environment long after cigarettes are 
      extinguished, which can react with other compounds in the environment to produce 
      secondary pollutants. However, the effects of THS on the female reproductive 
      system, particularly the maturation of the oocyte, remain unclear. 
      1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal (NNA), a component of THS, 
      is a logical biomarker of THS exposure. Thus, this study aims to investigate the 
      toxic effects of NNA on the maturation of murine oocytes and subsequent 
      developmental competence. Herein, murine oocytes were exposed to 0 (control 
      group), 0.1, 1.0, 10, and 50 muM NNA for 24 h. Our results showed that NNA 
      exposure reduced the polar body extrusion rate by causing 8-oxo-deoxyguanosine 
      (8-OHdG) to increase and disrupting the meiotic spindle morphology by inhibiting 
      ERK1/2 activation during in vitro maturation. Additionally, NNA exposure resulted 
      in cleavage and blastocyst rate reduction by altering DNA and histone 
      methylations by reducing 5 mC and H3K4me2 levels and by inducing apoptosis caused 
      by mitochondrial dysfunction and reactive oxygen species accumulation, as shown 
      by the increased superoxide dismutase mRNA level and by the decreased Bcl-x mRNA 
      level. Collectively, our results demonstrate that NNA exposure reduces the 
      maturation and developmental capability of murine oocytes by increasing the risk 
      of DNA damage and abnormal spindle morphology, altering epigenetic modifications, 
      and inducing apoptosis, suggesting the toxic effect of NNA on mammalian 
      productive health.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Liu, Huage
AU  - Liu H
AD  - State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China 
      Agricultural University, Yuanmingyuan West Rd 2, Haidian District, 100193 
      Beijing, China.
FAU - Liu, Zhiqiang
AU  - Liu Z
AD  - State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China 
      Agricultural University, Yuanmingyuan West Rd 2, Haidian District, 100193 
      Beijing, China.
FAU - Lu, Tengfei
AU  - Lu T
AD  - State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China 
      Agricultural University, Yuanmingyuan West Rd 2, Haidian District, 100193 
      Beijing, China.
FAU - Zhang, Luyao
AU  - Zhang L
AD  - State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China 
      Agricultural University, Yuanmingyuan West Rd 2, Haidian District, 100193 
      Beijing, China.
FAU - Cheng, Jinmei
AU  - Cheng J
AD  - (b)Nantong University Medical School, Qixiu Rd 19, Chongchuan District, 226001 
      Nantong, China.
FAU - Fu, Xiangwei
AU  - Fu X
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of 
      Agriculture and National Engineering Laboratory for Animal Breeding, College of 
      Animal Science and Technology, China Agricultural University, Yuanmingyuan West 
      Rd 2, Haidian District, 100193 Beijing, China.
FAU - Hou, Yunpeng
AU  - Hou Y
AD  - State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China 
      Agricultural University, Yuanmingyuan West Rd 2, Haidian District, 100193 
      Beijing, China. Electronic address: hou@cau.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20190615
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal)
RN  - 0 (Aldehydes)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Nitrosamines)
RN  - 0 (Pyridines)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Aldehydes/*toxicity
MH  - Animals
MH  - Apoptosis
MH  - DNA Damage
MH  - Environmental Pollutants/*toxicity
MH  - Epigenesis, Genetic
MH  - Female
MH  - Mice
MH  - Nitrosamines/*toxicity
MH  - Oocytes/*drug effects/growth & development/metabolism
MH  - Pyridines/*toxicity
MH  - Reactive Oxygen Species/metabolism
MH  - Spindle Apparatus/drug effects
OTO - NOTNLM
OT  - 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal
OT  - Apoptosis
OT  - DNA
OT  - Damage
OT  - Epigenetic modifications
OT  - Murine oocyte
OT  - Spindle damage
EDAT- 2019/06/19 06:00
MHDA- 2019/08/28 06:00
CRDT- 2019/06/19 06:00
PHST- 2019/03/08 00:00 [received]
PHST- 2019/05/31 00:00 [revised]
PHST- 2019/06/02 00:00 [accepted]
PHST- 2019/06/19 06:00 [pubmed]
PHST- 2019/08/28 06:00 [medline]
PHST- 2019/06/19 06:00 [entrez]
AID - S0147-6513(19)30634-7 [pii]
AID - 10.1016/j.ecoenv.2019.06.006 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2019 Oct 15;181:370-380. doi: 
      10.1016/j.ecoenv.2019.06.006. Epub 2019 Jun 15.