PMID- 31212252
OWN - NLM
STAT- MEDLINE
DCOM- 20200930
LR  - 20200930
IS  - 1873-1244 (Electronic)
IS  - 0899-9007 (Linking)
VI  - 66
DP  - 2019 Oct
TI  - Relationship between dietary non-enzymatic antioxidant capacity and type 2 
      diabetes risk in the Japan Public Health Center-based Prospective Study.
PG  - 62-69
LID - S0899-9007(18)30673-7 [pii]
LID - 10.1016/j.nut.2019.03.011 [doi]
AB  - OBJECTIVE: Intake of antioxidants may reduce the risk for type 2 diabetes (T2D) 
      by reducing oxidative stress. However, it is unclear whether dietary 
      non-enzymatic antioxidant capacity (NEAC), which represents the cumulative action 
      of dietary antioxidants and their synergistic effects in foods, is associated 
      with decreased T2D risk. The aim of this study was to investigate the 
      associations between dietary NEAC and T2D. METHODS: The study included 64 660 
      adults (27 809 men and 36 851 women), 44 to 76 y of age without history of T2D in 
      the Japan Public Health Center-based Prospective Study. Dietary NEAC was 
      estimated using databases of NEAC measurements compiled from results for three 
      different assays: ferric reducing-antioxidant power (FRAP), oxygen radical 
      absorbance capacity (ORAC), and total radical-trapping antioxidant parameter 
      (TRAP). A multiple logistic regression model was used to estimate odds ratios 
      (ORs) and 95% confidence intervals (CIs) of self-reported physician-diagnosed T2D 
      over 5 y with adjustment for potential confounders. RESULTS: In all, 1191 cases 
      of newly diagnosed T2D were reported. Dietary NEACs were not significantly 
      associated with T2D. The multivariate-adjusted ORs were 1.04 (95% CI, 0.88-1.23; 
      P(trend) = 0.56) for FRAP, 1.11 (95% CI, 0.93-1.32; P(trend) = 0.26) for ORAC, 
      and 0.99 (95% CI, 0.84-1.18; P(trend) = 0.84) for TRAP. Similar associations were 
      observed in men and women (P(interaction) = 0.46 for FRAP, 0.35 for ORAC, and 
      0.63 for TRAP). In stratified analyses of major prooxidant factors, no notable 
      associations with smoking and obesity status were observed. CONCLUSIONS: This 
      finding suggests that dietary NEAC may not be appreciably associated with T2D in 
      Japanese adults.
CI  - Copyright (c) 2019. Published by Elsevier Inc.
FAU - Kashino, Ikuko
AU  - Kashino I
AD  - Department of Epidemiology and Prevention, Center for Clinical Sciences, National 
      Center for Global Health and Medicine, Tokyo, Japan. Electronic address: 
      ikukokashino@gmail.com.
FAU - Serafini, Mauro
AU  - Serafini M
AD  - Functional Foods and Metabolic Stress Prevention Laboratory, Bioscience and 
      Technology for Food, Agriculture and Environment, University of Teramo, Teramo, 
      Italy.
FAU - Kurotani, Kayo
AU  - Kurotani K
AD  - Department of Epidemiology and Prevention, Center for Clinical Sciences, National 
      Center for Global Health and Medicine, Tokyo, Japan; Department of Nutritional 
      Epidemiology and Shokuiku, National Institute of Health and Nutrition, National 
      Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.
FAU - Akter, Shamima
AU  - Akter S
AD  - Department of Epidemiology and Prevention, Center for Clinical Sciences, National 
      Center for Global Health and Medicine, Tokyo, Japan.
FAU - Mizoue, Tetsuya
AU  - Mizoue T
AD  - Department of Epidemiology and Prevention, Center for Clinical Sciences, National 
      Center for Global Health and Medicine, Tokyo, Japan.
FAU - Ishihara, Junko
AU  - Ishihara J
AD  - Department of Food and Life Science School of Life and Environmental Science, 
      Azabu University, Kanagawa, Japan.
FAU - Kotemori, Ayaka
AU  - Kotemori A
AD  - Epidemiology and Prevention Group, Center for Public Health Sciences, National 
      Cancer Center, Tokyo, Japan.
FAU - Sawada, Norie
AU  - Sawada N
AD  - Epidemiology and Prevention Group, Center for Public Health Sciences, National 
      Cancer Center, Tokyo, Japan.
FAU - Inoue, Manami
AU  - Inoue M
AD  - Epidemiology and Prevention Group, Center for Public Health Sciences, National 
      Cancer Center, Tokyo, Japan.
FAU - Iwasaki, Motoki
AU  - Iwasaki M
AD  - Epidemiology and Prevention Group, Center for Public Health Sciences, National 
      Cancer Center, Tokyo, Japan.
FAU - Noda, Mitsushiko
AU  - Noda M
AD  - Department of Endocrinology and Diabetes, Saitama Medical University, Saitama, 
      Japan.
FAU - Tsugane, Shoichiro
AU  - Tsugane S
AD  - Epidemiology and Prevention Group, Center for Public Health Sciences, National 
      Cancer Center, Tokyo, Japan.
CN  - Japan Public Health Center-based Prospective Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190329
PL  - United States
TA  - Nutrition
JT  - Nutrition (Burbank, Los Angeles County, Calif.)
JID - 8802712
RN  - 0 (Antioxidants)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antioxidants/*metabolism
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Diet/*methods
MH  - Female
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Public Health
OTO - NOTNLM
OT  - Antioxidant
OT  - Antioxidant capacity
OT  - Cohort study
OT  - Diabetes
OT  - NEAC
OT  - TAC
EDAT- 2019/06/19 06:00
MHDA- 2020/10/02 06:00
CRDT- 2019/06/19 06:00
PHST- 2018/07/25 00:00 [received]
PHST- 2019/01/02 00:00 [revised]
PHST- 2019/03/26 00:00 [accepted]
PHST- 2019/06/19 06:00 [pubmed]
PHST- 2020/10/02 06:00 [medline]
PHST- 2019/06/19 06:00 [entrez]
AID - S0899-9007(18)30673-7 [pii]
AID - 10.1016/j.nut.2019.03.011 [doi]
PST - ppublish
SO  - Nutrition. 2019 Oct;66:62-69. doi: 10.1016/j.nut.2019.03.011. Epub 2019 Mar 29.