PMID- 31212300
OWN - NLM
STAT- MEDLINE
DCOM- 20200311
LR  - 20200311
IS  - 1421-9875 (Electronic)
IS  - 0257-2753 (Linking)
VI  - 38
IP  - 1
DP  - 2020
TI  - Cirrhosis Is a Predictor of Adverse Events in Endoscopic Ultrasound Fine-Needle 
      Aspiration: A Propensity-Score Analysis.
PG  - 69-76
LID - 10.1159/000501268 [doi]
AB  - BACKGROUND: Cirrhotic patients are at increased risk of adverse events (AEs) 
      after invasive procedures. However, the safety profile of endoscopic ultrasound 
      (EUS) fine-needle aspiration in cirrhotic patients is still unknown. OBJECTIVES: 
      To examine the AEs rate after EUS fine-needle aspiration in cirrhotic patients as 
      compared to a control group of noncirrhotic patients. METHODS: Out of 735 
      patients with suspected abdominal lesions referred to our center between 2006 and 
      2018, after propensity-score matching, 2 groups were compared: 95 cirrhotics and 
      95 controls. Primary variables included rate of overall and serious AEs. 
      Secondary endpoint was incidence of acute-on-chronic liver failure. RESULTS: 
      Median age was 64 years, and pancreatic lesions represented the sampled tissue in 
      57 patients (60%) in each group (p = 1.0) with mean size of 22 mm in both cohorts 
      (p = 0.3). Overall, 20 AEs (21%) of which 9 serious (9.4%) were observed in 
      cirrhotic patients and 3 (3.1%) mild events were experienced by noncirrhotic 
      subjects. Only liver cirrhosis was confirmed as a significant predictor of AEs in 
      multivariate analysis (OR 8.11, 2.34-28; p = 0.001). Overall rate of infections 
      was 6/95 (6.3%), of which 4 were serious (4.2%) in cirrhotics and 1/95 (1%) in 
      the control group (p = 0.05). All serious infections led to the occurrence of 
      acute-on-chronic liver failure. Minor bleeding events were more frequent in 
      cirrhotic patients (4.2 vs. 0%; p = 0.04). CONCLUSIONS: The rate of AEs after EUS 
      fine-needle aspiration is higher in cirrhotic patients, and acute-on-chronic 
      liver failure may represent a serious complication of this procedure.
CI  - (c) 2019 S. Karger AG, Basel.
FAU - Facciorusso, Antonio
AU  - Facciorusso A
AD  - Gastroenterology Unit, Department of Medical Sciences, University of Foggia, 
      Foggia, Italy, antonio.facciorusso@virgilio.it.
FAU - Buccino, Vincenzo Rosario
AU  - Buccino VR
AD  - Gastroenterology Unit, Department of Medical Sciences, University of Foggia, 
      Foggia, Italy.
FAU - Del Prete, Valentina
AU  - Del Prete V
AD  - Gastroenterology Unit, Department of Medical Sciences, University of Foggia, 
      Foggia, Italy.
FAU - Antonino, Matteo
AU  - Antonino M
AD  - Gastroenterology Unit, Department of Medical Sciences, University of Foggia, 
      Foggia, Italy.
FAU - Muscatiello, Nicola
AU  - Muscatiello N
AD  - Gastroenterology Unit, Department of Medical Sciences, University of Foggia, 
      Foggia, Italy.
LA  - eng
PT  - Journal Article
DEP - 20190618
PL  - Switzerland
TA  - Dig Dis
JT  - Digestive diseases (Basel, Switzerland)
JID - 8701186
SB  - IM
MH  - Aged
MH  - Endoscopic Ultrasound-Guided Fine Needle Aspiration/*adverse effects
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Liver Cirrhosis/*etiology/pathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Postoperative Complications/etiology
MH  - Prognosis
MH  - *Propensity Score
MH  - Regression Analysis
OTO - NOTNLM
OT  - Endoscopic ultrasound
OT  - Fine-needle aspiration
OT  - Liver function
OT  - Pancreas
EDAT- 2019/06/19 06:00
MHDA- 2020/03/12 06:00
CRDT- 2019/06/19 06:00
PHST- 2019/02/07 00:00 [received]
PHST- 2019/06/01 00:00 [accepted]
PHST- 2019/06/19 06:00 [pubmed]
PHST- 2020/03/12 06:00 [medline]
PHST- 2019/06/19 06:00 [entrez]
AID - 000501268 [pii]
AID - 10.1159/000501268 [doi]
PST - ppublish
SO  - Dig Dis. 2020;38(1):69-76. doi: 10.1159/000501268. Epub 2019 Jun 18.