PMID- 31213251
OWN - NLM
STAT- MEDLINE
DCOM- 20190808
LR  - 20190808
IS  - 1873-2534 (Electronic)
IS  - 0165-2427 (Linking)
VI  - 212
DP  - 2019 Jun
TI  - The detection of house dust mite Dermatophagoides farinae, Der f 2 and Zen-1 
      allergen-specific immunoglobulin E antibodies in dogs with atopic Dermatitis in 
      Malaysia.
PG  - 43-49
LID - S0165-2427(18)30241-1 [pii]
LID - 10.1016/j.vetimm.2019.05.002 [doi]
AB  - Canine atopic dermatitis (AD) is a chronic, inflammatory and pruritic allergic 
      skin disease in dogs. House dust mites such as Dermatophagoides farinae are one 
      of the known causative agents for the induction of canine AD worldwide. D. 
      farinae protein Der f 2 is known as an important allergen involved in canine AD 
      and recently, Zen-1 has also been identified as an allergenic protein. There is 
      limited information on the prevalence and role of allergen sensitization to crude 
      D. farinae extract (CDF), Der f 2 and Zen-1 among dogs diagnosed with AD in 
      Malaysia. The aim of this study was to determine the proportion of CDF-, Der f 2- 
      and Zen-1-specific reactive sera among dogs diagnosed with AD in Malaysia using 
      an enzyme-linked immunosorbent assay (ELISA). Serum samples were collected from 
      dogs diagnosed with AD from several veterinary clinics in Malaysia. The canine 
      case records were retrieved and information on signalment, dermatological and 
      non-dermatological histories, clinical presentation, food allergies, and 
      exclusion of ectoparasitic, microbial and fungal skin infections were obtained 
      through a survey form. All serum samples were evaluated to quantify the CDF-, Der 
      f 2- and Zen-1-specific immunoglobulin E (IgE) levels. A total of 24.6%, 48.4% 
      and 29.8% of dogs diagnosed with AD were positive for CDF-, Der f 2- and 
      Zen-1-specific IgE, respectively. These results suggest that CDF-, Der f 2- and 
      Zen-1 are important allergens that can contribute to AD in dogs in Malaysia, and 
      serological testing can be performed to provide additional treatment options 
      involving specific immunotherapies.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Chan, Wei Yee
AU  - Chan WY
AD  - Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, 
      Selangor, Malaysia.
FAU - Selvarajah, Gayathri Thevi
AU  - Selvarajah GT
AD  - Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, 
      Selangor, Malaysia. Electronic address: gayathri@upm.edu.my.
FAU - Ajat, Mokrish
AU  - Ajat M
AD  - Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, 
      Selangor, Malaysia.
FAU - Suzuki, Rieko
AU  - Suzuki R
AD  - Animal Life Science Laboratory, Nippon Zenyaku Kogyo Co., Ltd., Fukushima, 
      963-0196 Japan.
FAU - Tsukui, Toshihiro
AU  - Tsukui T
AD  - Animal Life Science Laboratory, Nippon Zenyaku Kogyo Co., Ltd., Fukushima, 
      963-0196 Japan.
LA  - eng
PT  - Journal Article
DEP - 20190522
PL  - Netherlands
TA  - Vet Immunol Immunopathol
JT  - Veterinary immunology and immunopathology
JID - 8002006
RN  - 0 (Allergens)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Arthropod Proteins)
RN  - 0 (Dermatophagoides farinae antigen f 2)
RN  - 37341-29-0 (Immunoglobulin E)
MH  - Allergens/immunology
MH  - Animals
MH  - Antigens, Dermatophagoides/blood/*immunology
MH  - Arthropod Proteins/blood/*immunology
MH  - Dermatitis, Atopic/immunology/parasitology/*veterinary
MH  - Dermatophagoides farinae
MH  - Dog Diseases/*immunology/parasitology
MH  - Dogs
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hospitals, Animal
MH  - Immunoglobulin E/*blood
MH  - Malaysia
MH  - Pets/immunology
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - CDF
OT  - Der f 2
OT  - Dogs
OT  - Dust mites
OT  - IgE
OT  - Zen-1
EDAT- 2019/06/20 06:00
MHDA- 2019/08/09 06:00
CRDT- 2019/06/20 06:00
PHST- 2018/06/09 00:00 [received]
PHST- 2019/02/05 00:00 [revised]
PHST- 2019/05/21 00:00 [accepted]
PHST- 2019/06/20 06:00 [entrez]
PHST- 2019/06/20 06:00 [pubmed]
PHST- 2019/08/09 06:00 [medline]
AID - S0165-2427(18)30241-1 [pii]
AID - 10.1016/j.vetimm.2019.05.002 [doi]
PST - ppublish
SO  - Vet Immunol Immunopathol. 2019 Jun;212:43-49. doi: 10.1016/j.vetimm.2019.05.002. 
      Epub 2019 May 22.