PMID- 31213764
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1177-5467 (Print)
IS  - 1177-5483 (Electronic)
IS  - 1177-5467 (Linking)
VI  - 13
DP  - 2019
TI  - Long-term changes of retinal pigment epithelium in the eyes with 
      Vogt-Koyanagi-Harada disease observed by adaptive optics imaging.
PG  - 927-933
LID - 10.2147/OPTH.S199886 [doi]
AB  - Purpose: To observe long-term changes of the retinal pigment epithelium (RPE) in 
      the eyes of patients with Vogt-Koyanagi-Harada (VKH) disease using an adaptive 
      optics (AO) fundus camera, and their correlation with the findings of 
      spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence 
      (AF) imaging. Patients and methods: Three eyes of two patients with new-onset 
      acute VKH disease were retrospectively studied. After the serous retinal 
      detachment was resolved by high-dose corticosteroid treatment, the patients were 
      examined with SD-OCT, blue-wavelength AF, near-infrared (NIR) AF, and an AO 
      fundus camera. AO images of the macula were obtained using the rtx1(TM) AO fundus 
      camera. The area around the foveal center of the hyper-reflective lesion in AO 
      imaging was measured manually. The time at which the serous retinal detachment 
      resolved was set as the baseline, and AO and other images were obtained every 3 
      to 6 months from the baseline. Results: In all three eyes, lesions with elevation 
      or thickening of the RPE layer were observed with OCT imaging in the macula after 
      the serous retinal detachment resolved. These lesions showed 
      hyper-autofluorescence in NIR-AF image and hyper-reflective lesions with clear 
      boundaries in AO image. The area of the hyper-reflective lesions of AO images in 
      each eye showed an approximately 40% decrease at 6 months from baseline. However, 
      the hyper-reflective lesion remained to some extent after 18 months in case 1 and 
      36 months in case 2. Conclusions: By using OCT, fundus autofluorescence and AO 
      images, it was possible to observe temporal changes of RPE layer in VKH eyes 
      noninvasively. High-resolution AO images also allow us to observe for 
      improvements in the elevation or thickening of the RPE layer quantitatively.
FAU - Nakamura, Tomoko
AU  - Nakamura T
AD  - Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical 
      Sciences, University of Toyama, Toyama, Japan.
FAU - Hayashi, Atsushi
AU  - Hayashi A
AD  - Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical 
      Sciences, University of Toyama, Toyama, Japan.
FAU - Oiwake, Toshihiko
AU  - Oiwake T
AD  - Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical 
      Sciences, University of Toyama, Toyama, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190531
PL  - New Zealand
TA  - Clin Ophthalmol
JT  - Clinical ophthalmology (Auckland, N.Z.)
JID - 101321512
PMC - PMC6549749
OTO - NOTNLM
OT  - Vogt-Koyanagi-Harada disease
OT  - adaptive optics
OT  - fundus autofluorescence
OT  - near-infrared imaging
OT  - retinal pigment epithelium
COIS- The authors report no conflicts of interest in this work.
EDAT- 2019/06/20 06:00
MHDA- 2019/06/20 06:01
PMCR- 2019/05/31
CRDT- 2019/06/20 06:00
PHST- 2018/12/29 00:00 [received]
PHST- 2019/04/26 00:00 [accepted]
PHST- 2019/06/20 06:00 [entrez]
PHST- 2019/06/20 06:00 [pubmed]
PHST- 2019/06/20 06:01 [medline]
PHST- 2019/05/31 00:00 [pmc-release]
AID - 199886 [pii]
AID - 10.2147/OPTH.S199886 [doi]
PST - epublish
SO  - Clin Ophthalmol. 2019 May 31;13:927-933. doi: 10.2147/OPTH.S199886. eCollection 
      2019.