PMID- 31214111
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 10
DP  - 2019
TI  - Ischemic Stroke in Pontine and Corona Radiata: Location Specific Impairment of 
      Neural Network Investigated With Resting State fMRI.
PG  - 575
LID - 10.3389/fneur.2019.00575 [doi]
LID - 575
AB  - Objective: This study aims to investigate location-specific functional remodeling 
      following ischemic stroke in pons and corona radiata. Methods: This study was 
      approved by the local Institutional Review Board. Written consent was obtained 
      from each of the participants prior to the MRI examination. Thirty six subjects 
      with first ever acute ischemic stroke in pons (PS, n = 15, aged 62.8 +/- 11.01 
      years) or corona radiata (CRS, n = 21, aged 59.33 +/- 13.84 years) as well as 30 
      age and sex matched healthy controls (HC, n = 30, aged 60 +/- 6.43 years) were 
      examined with resting state functional magnetic resonance imaging (rs-fMRI). 
      Regional homogeneity (ReHo) and degree centrality (DC) were calculated using a 
      voxel-based approach. Intergroup differences in ReHo and DC were explored using a 
      permutation test with a threshold-free cluster enhancement (PT TFCE, number of 
      permutations = 1,000, family-wise error rate (FWER) < 0.05). Results: ReHo and DC 
      alterations were identified in distributed anatomies for both PS and CRS groups. 
      DC mainly increased in the bilateral anterior and posterior cingulate cortex, the 
      inferior frontal-orbital gyrus, and decreased in the bilateral cuneus, calcarine, 
      and the precuneus, while ReHo mainly decreased in the precentral and the 
      postcentral gyri, inferior parietal lobules, precuneus, posterior cingulate 
      cortex, and the superior occipital gyrus. PS and CRS groups were not 
      significantly different in ReHo or DC (FWER > 0.05). Conclusions: Focal ischemic 
      stroke in pons or corona radiata leads to extensive alterations in the functional 
      network centrality. IS-induced network remodeling is more anatomy-specific than 
      pathway-specific, which may underpin the clinicotopographical profiles during the 
      disease dynamic. Approaches targeting neural pathway and functional connectivity 
      may shed light on a better characterization and management innovation of ischemic 
      stroke.
FAU - Jiang, Chunxiang
AU  - Jiang C
AD  - Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of 
      Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
AD  - Shenzhen College of Advanced Technology, University of Chinese Academy of 
      Sciences, Shenzhen, China.
FAU - Yi, Li
AU  - Yi L
AD  - Department of Neurology Peking University Shenzhen Hospital, Shenzhen, China.
FAU - Cai, Siqi
AU  - Cai S
AD  - Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of 
      Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
FAU - Zhang, Lijuan
AU  - Zhang L
AD  - Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of 
      Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
LA  - eng
PT  - Journal Article
DEP - 20190531
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC6554416
OTO - NOTNLM
OT  - corona radiata
OT  - degree centrality
OT  - pontine
OT  - regional homogeneity
OT  - resting-state fMRI
OT  - stroke
EDAT- 2019/06/20 06:00
MHDA- 2019/06/20 06:01
PMCR- 2019/05/31
CRDT- 2019/06/20 06:00
PHST- 2019/02/12 00:00 [received]
PHST- 2019/05/15 00:00 [accepted]
PHST- 2019/06/20 06:00 [entrez]
PHST- 2019/06/20 06:00 [pubmed]
PHST- 2019/06/20 06:01 [medline]
PHST- 2019/05/31 00:00 [pmc-release]
AID - 10.3389/fneur.2019.00575 [doi]
PST - epublish
SO  - Front Neurol. 2019 May 31;10:575. doi: 10.3389/fneur.2019.00575. eCollection 
      2019.