PMID- 31214852
OWN - NLM
STAT- MEDLINE
DCOM- 20200106
LR  - 20200225
IS  - 1567-2387 (Electronic)
IS  - 1567-2379 (Linking)
VI  - 50
IP  - 4
DP  - 2019 Aug
TI  - Osteoclastogenesis from bone marrow cells during estrogen-induced medullary bone 
      formation in Japanese quails.
PG  - 389-404
LID - 10.1007/s10735-019-09835-x [doi]
AB  - Osteoclasts are differentiated from hematopoietic mononuclear cells by regulation 
      of the receptor activator of nuclear factor kappa-B (RANK)/receptor activator of 
      nuclear factor kappa-B ligand (RANKL)/osteoprotegerin (OPG) system. Medullary 
      bone (MB) that forms in the bone marrow of female birds is remodeled under the 
      control of circulating estrogen (E2) during the laying period. Although the 
      osteoclasts of MB are differentiated from mononuclear cells, the mechanism of 
      osteoclastogenesis is not known. We investigated whether MB osteoclastogenesis is 
      regulated by the RANK/RANKL/OPG system using MB from male quails induced with E2. 
      Bone marrow cells (BMCs) differentiate into osteoclasts that have the ability of 
      bone resorption via stimulation of RANKL/M-CSF, but this ability is suppressed by 
      OPG and differentiation is inhibited by calcinurin inhibitors. We found that BMCs 
      at 3 days after E2 administration had high bone osteoclastogenesis ability and 
      colony forming unit-granulocyte/macrophage (CFU-GM)/colony forming 
      unit-macrophage (CFU-M) formation abilities. We conclude that MB osteoclasts are 
      differentiated from BMCs by the RANK/RANKL/OPG system, and that precursor cells 
      of osteoclasts are increased during MB formation.
FAU - Hiyama, Shinji
AU  - Hiyama S
AD  - Department of Oral Biology, Graduate School of Biomedical & Health Sciences, 
      Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan. 
      showsuke006@gmail.com.
FAU - Yokoi, Miyuki
AU  - Yokoi M
AD  - Department of Advanced Prosthodontics, Graduate School of Biomedical & Health 
      Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, 
      Japan.
FAU - Akagi, Yuichi
AU  - Akagi Y
AD  - Faculty of Dentistry, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 
      734-8553, Japan.
FAU - Kadoyama, Yumiko
AU  - Kadoyama Y
AD  - Faculty of Dentistry, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 
      734-8553, Japan.
FAU - Nakamori, Kiichi
AU  - Nakamori K
AD  - Department of Advanced Prosthodontics, Graduate School of Biomedical & Health 
      Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, 
      Japan.
FAU - Tsuga, Kazuhiro
AU  - Tsuga K
AD  - Department of Advanced Prosthodontics, Graduate School of Biomedical & Health 
      Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, 
      Japan.
FAU - Uchida, Takashi
AU  - Uchida T
AD  - Department of Oral Biology, Graduate School of Biomedical & Health Sciences, 
      Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
FAU - Terayama, Ryuji
AU  - Terayama R
AD  - Department of Maxillofacial Anatomy and Neuroscience, Graduate School of 
      Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 
      Hiroshima, 734-8553, Japan.
LA  - eng
GR  - JP21791787/JSPS KAKENHI grants/
GR  - JP24791963/JSPS KAKENHI grants/
PT  - Journal Article
DEP - 20190618
PL  - Netherlands
TA  - J Mol Histol
JT  - Journal of molecular histology
JID - 101193653
RN  - 0 (Estrogens)
RN  - 0 (Osteoprotegerin)
RN  - 0 (RANK Ligand)
RN  - 0 (Receptor Activator of Nuclear Factor-kappa B)
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/*cytology
MH  - Cell Differentiation
MH  - Coturnix/*physiology
MH  - Estrogens/*pharmacology
MH  - Female
MH  - Osteoclasts/cytology
MH  - Osteogenesis/drug effects/*physiology
MH  - Osteoprotegerin/metabolism
MH  - RANK Ligand/metabolism
MH  - Receptor Activator of Nuclear Factor-kappa B/metabolism
OTO - NOTNLM
OT  - Estrogen
OT  - Medullary bone
OT  - Osteoclastogenesis
OT  - Osteoclasts
EDAT- 2019/06/20 06:00
MHDA- 2020/01/07 06:00
CRDT- 2019/06/20 06:00
PHST- 2019/04/22 00:00 [received]
PHST- 2019/06/11 00:00 [accepted]
PHST- 2019/06/20 06:00 [pubmed]
PHST- 2020/01/07 06:00 [medline]
PHST- 2019/06/20 06:00 [entrez]
AID - 10.1007/s10735-019-09835-x [pii]
AID - 10.1007/s10735-019-09835-x [doi]
PST - ppublish
SO  - J Mol Histol. 2019 Aug;50(4):389-404. doi: 10.1007/s10735-019-09835-x. Epub 2019 
      Jun 18.