PMID- 31216691
OWN - NLM
STAT- MEDLINE
DCOM- 20191127
LR  - 20231012
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 12
DP  - 2019 Jun 18
TI  - Graphene- and Graphene Oxide-Based Nanocomposite Platforms for Electrochemical 
      Biosensing Applications.
LID - 10.3390/ijms20122975 [doi]
LID - 2975
AB  - Graphene and its derivatives such as graphene oxide (GO) and reduced GO (rGO) 
      offer excellent electrical, mechanical and electrochemical properties. Further, 
      due to the presence of high surface area, and a rich oxygen and defect framework, 
      they are able to form nanocomposites with metal/semiconductor nanoparticles, 
      metal oxides, quantum dots and polymers. Such nanocomposites are becoming 
      increasingly useful as electrochemical biosensing platforms. In this review, we 
      present a brief introduction on the aforementioned graphene derivatives, and 
      discuss their synthetic strategies and structure-property relationships important 
      for biosensing. We then highlight different nanocomposite platforms that have 
      been developed for electrochemical biosensing, introducing enzymatic biosensors, 
      followed by non-enzymatic biosensors and immunosensors. Additionally, we briefly 
      discuss their role in the emerging field of biomedical cell capture. Finally, a 
      brief outlook on these topics is presented.
FAU - Thangamuthu, Madasamy
AU  - Thangamuthu M
AUID- ORCID: 0000-0001-8391-3769
AD  - Nanophotonics and Metrology Laboratory (NAM), Swiss Federal Institute of 
      Technology Lausanne (EPFL), 1015 Lausanne, Switzerland. 
      madasamy.thangamuthu@epfl.ch.
FAU - Hsieh, Kuan Yu
AU  - Hsieh KY
AUID- ORCID: 0000-0003-3021-7684
AD  - Institute of Biomedical Engineering, College of Electrical and Computer 
      Engineering, National Chiao Tung University, Hsinchu 300, Taiwan. 
      Kuan.Yu@ibm.com.
AD  - Department of Electrical and Computer Engineering, College of Electrical and 
      Computer Engineering, National Chiao Tung University, Hsinchu 300, Taiwan. 
      Kuan.Yu@ibm.com.
FAU - Kumar, Priyank V
AU  - Kumar PV
AUID- ORCID: 0000-0002-8203-7223
AD  - School of Chemical Engineering, University of New South Wales, Sydney, NSW 2052, 
      Australia. priyank.kumar@unsw.edu.au.
FAU - Chen, Guan-Yu
AU  - Chen GY
AUID- ORCID: 0000-0002-3443-7943
AD  - Institute of Biomedical Engineering, College of Electrical and Computer 
      Engineering, National Chiao Tung University, Hsinchu 300, Taiwan. 
      guanyu@nctu.edu.tw.
AD  - Department of Biological Science and Technology, College of Biological Science 
      and Technology, National Chiao Tung University, Hsinchu 300, Taiwan. 
      guanyu@nctu.edu.tw.
LA  - eng
GR  - 108W204, 108W211/National Chiao Tung University/
GR  - MOST 107-2622-E-009-023-CC1, 
      MOST-107-EPA-F-007-002,MOST-108-2636-E-009-007-/Ministry of Science and 
      Technology, Taiwan/
GR  - NHRI-EX108-10714EC/National Health Research Institutes Taiwan/
GR  - none/the Higher Education Sprout Project of the National Chiao Tung University 
      and the Ministry of Education, Taiwan/
PT  - Journal Article
PT  - Review
DEP - 20190618
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (graphene oxide)
RN  - 7782-42-5 (Graphite)
SB  - IM
MH  - *Biosensing Techniques
MH  - *Electrochemical Techniques
MH  - Graphite/chemical synthesis/*chemistry
MH  - Models, Molecular
MH  - Molecular Conformation
MH  - Nanocomposites/*chemistry/ultrastructure
PMC - PMC6628170
OTO - NOTNLM
OT  - cell capture
OT  - electrochemical biosensor
OT  - graphene
OT  - graphene oxide
OT  - reduced graphene oxide
COIS- The authors declare no conflict of interest.
EDAT- 2019/06/21 06:00
MHDA- 2019/11/28 06:00
PMCR- 2019/06/01
CRDT- 2019/06/21 06:00
PHST- 2019/04/24 00:00 [received]
PHST- 2019/06/01 00:00 [revised]
PHST- 2019/06/04 00:00 [accepted]
PHST- 2019/06/21 06:00 [entrez]
PHST- 2019/06/21 06:00 [pubmed]
PHST- 2019/11/28 06:00 [medline]
PHST- 2019/06/01 00:00 [pmc-release]
AID - ijms20122975 [pii]
AID - ijms-20-02975 [pii]
AID - 10.3390/ijms20122975 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 Jun 18;20(12):2975. doi: 10.3390/ijms20122975.