PMID- 31216908
OWN - NLM
STAT- MEDLINE
DCOM- 20191212
LR  - 20191217
IS  - 1651-2006 (Electronic)
IS  - 1401-7431 (Linking)
VI  - 53
IP  - 5
DP  - 2019 Oct
TI  - Aiming toWards Evidence baSed inTerpretation of Cardiac biOmarkers in patients 
      pResenting with chest pain-the WESTCOR study: study design.
PG  - 280-285
LID - 10.1080/14017431.2019.1634280 [doi]
AB  - Objectives. The main aim of the Aiming toWards Evidence baSed inTerpretation of 
      Cardiac biOmarkers in patients pResenting with chest pain (WESTCOR-study) 
      (Clinical Trials number NCT02620202) is to improve diagnostic pathways for 
      patients presenting to the Emergency department (ED) with acute chest pain. 
      Design. The WESTCOR-study is a two center, cross-sectional and prospective 
      observational study recruiting unselected patients presenting to the ED with 
      suspected non-ST elevation acute coronary syndrome (NSTE-ACS). Patient inclusion 
      started September 2015 and we plan to include 2250 patients, finishing in 2019. 
      The final diagnosis will be adjudicated by two independent cardiologists based on 
      all available information including serial high sensitivity cardiac troponin 
      measurements, coronary angiography, coronary CT angiography and echocardiography. 
      The study includes one derivation cohort (N = 985) that will be used to develop 
      rule out/rule in algorithms for NSTEMI and NSTE-ACS (if possible) using novel 
      troponin assays, and to validate established NSTEMI algorithms, with and without 
      clinical scoring systems. The study further includes one subcohort (n = 500) 
      where all patients are examined with coronary CT angiography independent of 
      biomarker status, aiming to assess the associations between biomarkers and the 
      extent and severity of coronary atherosclerosis. Finally, an external validation 
      cohort (N = 750) will be included at Stavanger University Hospital. Prospective 
      studies will be based on the merged cohorts. Conclusion. The WESTCOR study will 
      provide new diagnostic algorithms for early inclusion and exclusion of NSTE-ACS 
      and insights in the associations between cardiovascular biomarkers, 
      CT-angiographic findings and short and long-term clinical outcomes.
FAU - Tjora, Hilde L
AU  - Tjora HL
AD  - Emergency Care Clinic, Haukeland University Hospital , Bergen , Norway.
FAU - Steiro, Ole-Thomas
AU  - Steiro OT
AD  - Department of Heart Disease, Haukeland University Hospital , Bergen , Norway.
FAU - Langorgen, Jorund
AU  - Langorgen J
AD  - Department of Heart Disease, Haukeland University Hospital , Bergen , Norway.
FAU - Bjorneklett, Rune
AU  - Bjorneklett R
AD  - Emergency Care Clinic, Haukeland University Hospital , Bergen , Norway.
AD  - Department of Clinical Medicine, University of Bergen , Bergen , Norway.
FAU - Nygard, Ottar K
AU  - Nygard OK
AD  - Department of Heart Disease, Haukeland University Hospital , Bergen , Norway.
AD  - Department of Clinical Science, University of Bergen , Bergen , Norway.
FAU - Renstrom, Renate
AU  - Renstrom R
AD  - Department of Medical Biochemistry and Pharmacology, Haukeland University 
      Hospital , Bergen , Norway.
FAU - Skadberg, Oyvind
AU  - Skadberg O
AD  - Laboratory of Medical Biochemistry, Stavanger University Hospital , Stavanger , 
      Norway.
FAU - Bonarjee, Vernon V S
AU  - Bonarjee VVS
AD  - Cardiology Department, Stavanger University Hospital , Stavanger , Norway.
FAU - Lindahl, Bertil
AU  - Lindahl B
AD  - Department of Medical Sciences, Uppsala University , Uppsala , Sweden.
AD  - Uppsala Clinical Research Center, Uppsala University , Uppsala , Sweden.
FAU - Collinson, Paul
AU  - Collinson P
AD  - Departments of Clinical Blood Sciences and Cardiology, St Georges University 
      Hospitals NHS Foundation Trust and St George's University of London , London , 
      UK.
FAU - Omland, Torbjorn
AU  - Omland T
AD  - Division of Medicine, Akershus University Hospital , Oslo , Norway.
AD  - Center for Heart Failure Research, Institute of Clinical Medicine, University of 
      Oslo , Oslo , Norway.
FAU - Vikenes, Kjell
AU  - Vikenes K
AD  - Department of Heart Disease, Haukeland University Hospital , Bergen , Norway.
AD  - Department of Clinical Science, University of Bergen , Bergen , Norway.
FAU - Aakre, Kristin M
AU  - Aakre KM
AD  - Department of Clinical Science, University of Bergen , Bergen , Norway.
AD  - Department of Medical Biochemistry and Pharmacology, Haukeland University 
      Hospital , Bergen , Norway.
AD  - Hormone Laboratory, Haukeland University Hospital , Bergen , Norway.
LA  - eng
PT  - Journal Article
DEP - 20190701
PL  - England
TA  - Scand Cardiovasc J
JT  - Scandinavian cardiovascular journal : SCJ
JID - 9708377
RN  - 0 (Biomarkers)
RN  - 0 (Troponin)
SB  - IM
MH  - Acute Coronary Syndrome/blood/*diagnosis/mortality
MH  - Algorithms
MH  - Angina, Unstable/blood/*diagnosis/mortality
MH  - Biomarkers/blood
MH  - Computed Tomography Angiography
MH  - Coronary Angiography/methods
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Multicenter Studies as Topic
MH  - Non-ST Elevated Myocardial Infarction/blood/*diagnosis/mortality
MH  - Norway
MH  - Observational Studies as Topic
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - *Research Design
MH  - Troponin/*blood
OTO - NOTNLM
OT  - Chest pain
OT  - NSTEMI
OT  - acute coronary syndrome
OT  - cardiovascular biomarkers
OT  - rule in/rule out algorithms
OT  - troponin
OT  - unstable angina pectoris
EDAT- 2019/06/21 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/06/21 06:00
PHST- 2019/06/21 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/06/21 06:00 [entrez]
AID - 10.1080/14017431.2019.1634280 [doi]
PST - ppublish
SO  - Scand Cardiovasc J. 2019 Oct;53(5):280-285. doi: 10.1080/14017431.2019.1634280. 
      Epub 2019 Jul 1.