PMID- 31219449
OWN - NLM
STAT- MEDLINE
DCOM- 20191230
LR  - 20191230
IS  - 1308-4488 (Electronic)
IS  - 1016-5169 (Linking)
VI  - 47
IP  - 4
DP  - 2019 Jun
TI  - Liver stiffness value obtained with ElastPQ ultrasound increases with NYHA class 
      in chronic heart failure patients and reduced ejection fraction.
PG  - 281-293
LID - 10.5543/tkda.2018.62282 [doi]
AB  - OBJECTIVE: Liver stiffness (LS) values are known to be associated with increased 
      right ventricle (RV) pressure in patients with heart failure (HF). The aim of 
      this study was to determine the changes in LS in patients of different New York 
      Heart Association (NYHA) classes and the parameters related to increased LS in HF 
      patients with reduced ejection fraction (HFrEF). METHODS: A total of 181 patients 
      with HFrEF were included in the study. Routine anamnesis, physical examination, 
      laboratory examinations and echocardiography were performed. The LS measurement 
      was performed using the ElastPQ technique. The patients were grouped by NYHA 
      class I-IV. RESULTS: The LS values were significantly different between NYHA 
      class groups, increasing significantly from NYHA class I to IV. The number of 
      patients with LS >7 kPa or >10.6 kPa was significantly greater among the class 
      III-IV patients. The RV myocardial performance index, tricuspid regurgitation 
      pressure gradient, N-terminal pro b-type natriuretic peptide, and aspartate 
      aminotransferase levels were found to be independently associated with LS. It was 
      also observed that LS independently determined III-IV classification and that an 
      increase of 1 kPa increased the risk of being class III-IV by 94.4%. Receiver 
      operating characteristic analysis with a cut-off value of 7 kPa for LS identified 
      patients with class III-IV disease with 82.8% sensitivity and 81.8% specificity. 
      CONCLUSION: In HFrEF, the LS value increased with NYHA class and independently 
      determined patients with class III-IV disease. A higher LS value independently 
      determined increased RV pressure and systolic functions.
FAU - Icen, Yahya Kemal
AU  - Icen YK
AD  - Department of Cardiology, Health Sciences University Adana Health Practices and 
      Research Center, Adana, Turkey.
FAU - Demirtas, Abdullah Orhan
AU  - Demirtas AO
AD  - Department of Cardiology, Health Sciences University Adana Health Practices and 
      Research Center, Adana, Turkey.
FAU - Koc, Ayse Selcan
AU  - Koc AS
AD  - Department of Radiology, Health Sciences University Adana Health Practices and 
      Research Center, Adana, Turkey.
FAU - Sumbul, Hilmi Erdem
AU  - Sumbul HE
AD  - Department of Internal Diseases, Health Sciences University Adana Health 
      Practices and Research Center, Adana.
FAU - Koc, Mevlut
AU  - Koc M
AD  - Department of Cardiology, Health Sciences University Adana Health Practices and 
      Research Center, Adana, Turkey.
LA  - eng
PT  - Journal Article
TT  - Dusuk ejeksiyon fraksiyonu olan kronik kalp yetersizligi hastalarinda ElastPQ 
      ultrasonografi ile elde edilen karaciger sertlik degeri NYHA evresi ile artar.
PL  - Turkey
TA  - Turk Kardiyol Dern Ars
JT  - Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir
JID - 9426239
SB  - IM
MH  - Female
MH  - Heart Failure/*complications/diagnostic imaging
MH  - Humans
MH  - Liver/diagnostic imaging/*pathology
MH  - Male
MH  - Middle Aged
MH  - Stroke Volume
MH  - Ultrasonography/methods
EDAT- 2019/06/21 06:00
MHDA- 2019/12/31 06:00
CRDT- 2019/06/21 06:00
PHST- 2019/06/21 06:00 [entrez]
PHST- 2019/06/21 06:00 [pubmed]
PHST- 2019/12/31 06:00 [medline]
AID - 10.5543/tkda.2018.62282 [doi]
PST - ppublish
SO  - Turk Kardiyol Dern Ars. 2019 Jun;47(4):281-293. doi: 10.5543/tkda.2018.62282.