PMID- 31222434 OWN - NLM STAT- MEDLINE DCOM- 20200227 LR - 20200309 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 24 IP - 2 DP - 2020 Feb TI - Somatosensory profiling of patients with plaque-induced gingivitis: a case-control study. PG - 875-882 LID - 10.1007/s00784-019-02963-4 [doi] AB - OBJECTIVES: This study aimed to assess the mechanical and thermal sensory thresholds of the gingiva in patients with plaque-induced gingivitis compared with a control group to help characterize effects of an inflammatory condition in the oral mucosa on somatosensory function. MATERIALS AND METHODS: Quantitative sensory testing (QST) was used in 22 patients (men 10, women 12, age 20-30 years) with plaque-induced gingivitis at the lower lateral incisors and in 22 age- and gender-matched healthy volunteers as a control group. One lower lateral incisor (32 or 42) was randomly identified for each included subject. Cold detection threshold (CDT), warm detection threshold (WDT), cold pain threshold (CPT), and heat pain threshold (HPT) of the attached gingiva at the identified lower lateral incisors were assessed in both groups. Pressure pain threshold (PPT) at the teeth was also tested from vertical and lateral directions and analyzed. One-way ANOVA was used to compare the mean values of the identified lower lateral incisors between the two groups. RESULTS: The results showed that the CDT (P = 0.027), WDT (P = 0.021), and HPT (P = 0.005) at the gingiva and PPT (P < 0.001) at the identified lower lateral incisors from the vertical direction were significantly less sensitive, whereas the PPT (P = 0.016) at the gingiva of the identified lateral incisors were significantly more sensitive in the gingivitis group compared to the control group. Plaque-induced gingivitis and the inflammatory response appear to be associated with significant changes in somatosensory sensitivity at the gingiva and periodontal tissue in a bidirectional mode, i.e., both increased and decreased sensitivity to different types of stimuli. CONCLUSIONS: Inflammatory reactions in the gingiva seem to be associated with demonstrable changes in somatosensory function including both hypo- and hyperesthesia. CLINICAL RELEVANCE: These findings may have significance for general oral health and well-being in patients with even plaque-induced gingivitis. FAU - Wang, Chen AU - Wang C AD - Orofacial Pain & TMD Research Unit, Institute of Stomatology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China. AD - Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China. FAU - Zhou, Xin AU - Zhou X AD - Department of Orthodontics, The Affiliated Wuxi Mental Health Center of Nanjing Medical University, Wuxi, China. FAU - Chen, Yaming AU - Chen Y AUID- ORCID: 0000-0002-2927-1299 AD - Orofacial Pain & TMD Research Unit, Institute of Stomatology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China. 593983325@qq.com. AD - Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China. 593983325@qq.com. AD - Department of Polyclinic, Institute of Stomatology, Affiliated Hospital of Stomatology, Nanjing Medical University, 136 Hanzhong Rd, Nanjing, 210029, China. 593983325@qq.com. FAU - Zhang, Jinglu AU - Zhang J AD - Orofacial Pain & TMD Research Unit, Institute of Stomatology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China. zhjllym@njmu.edu.cn. AD - Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China. zhjllym@njmu.edu.cn. AD - Department of Polyclinic, Institute of Stomatology, Affiliated Hospital of Stomatology, Nanjing Medical University, 136 Hanzhong Rd, Nanjing, 210029, China. zhjllym@njmu.edu.cn. FAU - Chen, Wu AU - Chen W AD - Department of Periodontology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China. FAU - Svensson, Peter AU - Svensson P AD - Section of Orofacial Pain and Jaw Function, School of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark. AD - Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden. AD - Scandinavian Center for Orofacial Neurosciences (SCON), Stockholm, Sweden. FAU - Wang, Kelun AU - Wang K AD - Orofacial Pain & TMD Research Unit, Institute of Stomatology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China. AD - Section of Orofacial Pain and Jaw Function, School of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark. AD - Center for Sensory-Motor Interaction (SMI), Department of Health Science & Technology, Aalborg University, Aalborg, Denmark. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20190620 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 MH - Adult MH - Case-Control Studies MH - Female MH - *Gingivitis MH - Hot Temperature MH - Humans MH - Male MH - *Pain Threshold MH - Sensory Thresholds MH - Young Adult OTO - NOTNLM OT - Plaque-induced gingivitis OT - Pressure pain threshold OT - Quantitative sensory testing OT - Thermal sensory thresholds EDAT- 2019/06/22 06:00 MHDA- 2020/02/28 06:00 CRDT- 2019/06/22 06:00 PHST- 2018/09/25 00:00 [received] PHST- 2019/05/16 00:00 [accepted] PHST- 2019/06/22 06:00 [pubmed] PHST- 2020/02/28 06:00 [medline] PHST- 2019/06/22 06:00 [entrez] AID - 10.1007/s00784-019-02963-4 [pii] AID - 10.1007/s00784-019-02963-4 [doi] PST - ppublish SO - Clin Oral Investig. 2020 Feb;24(2):875-882. doi: 10.1007/s00784-019-02963-4. Epub 2019 Jun 20.