PMID- 31222592
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231104
IS  - 1869-6953 (Print)
IS  - 1869-6961 (Electronic)
IS  - 1869-6961 (Linking)
VI  - 10
IP  - 4
DP  - 2019 Aug
TI  - Influence of Supervised Disease Understanding and Diabetes Self-Management on 
      Adherence to Oral Glucose-Lowering Treatment in Patients with Type 2 Diabetes.
PG  - 1407-1422
LID - 10.1007/s13300-019-0648-9 [doi]
AB  - INTRODUCTION: Systematic patient education has been reported to improve adherence 
      to treatment, leading to better clinical outcomes. This cluster randomized 
      real-world study investigated the effect of a systematic education program and 
      telephone support on self-reported adherence to oral glucose-lowering treatment 
      in patients with type 2 diabetes mellitus (T2DM). METHODS: Centers were 
      randomized (1:1) to provide either standard-of-care (control group) or 
      standard-of-care along with the education program and telephone support 
      (empowerment group). Adherence to treatment and satisfaction with treatment were 
      assessed using the four-item Morisky Medication Adherence Scale (MMAS-4) and the 
      Diabetes Treatment Satisfaction Questionnaire (DTSQ). The study population 
      included 457 patients (258/199 male/female) with T2DM and non-optimal glycemic 
      control, on oral antidiabetic treatment (age 62.7 [11.4]; disease duration 8.5 
      [6.5] years). RESULTS: MMAS-4 high adherence rates for the control and 
      empowerment groups were increased by 3.8% and 16.8% at 4 months (Breslow-Day test 
      p = 0.04) and by 8.5% and 18.8% at 8 months of follow-up, respectively 
      (Breslow-Day test p = 0.09), compared to baseline. Intense physical activity was 
      increased in both control and empowerment groups by 2.3% and 13.9% at 4 months 
      (Breslow-Day test p = 0.082) and by 4.0% and 22.5% at 8 months of follow-up 
      (Breslow-Day test p < 0.001). Baseline mean (SD) HbA1c was significantly lower in 
      the control group compared with the empowerment group [7.7% versus 8.0%, 
      p = 0.001] and decreased in both groups at 4 months by 0.7% and 0.9%, 
      respectively. The change from baseline in the mean DTSQ status score at 4 months 
      was greater in the empowerment group, and the effect was sustained at 8 months 
      (control group: 29.1, 30.5, and 30.9; empowerment group: 25.0, 28.7, and 29.4 at 
      baseline, 4 and 8 months, respectively, p < 0.001). CONCLUSION: Systematic 
      education combined with telephone support delivered by physicians might be 
      associated with improvement in treatment adherence and treatment satisfaction in 
      patients with T2DM. FUNDING: MSD, Greece.
FAU - Doupis, John
AU  - Doupis J
AD  - Internal Medicine and Diabetes Department, NS Naval Hospital, Athens, Greece. 
      john.doupis@joslin.harvard.edu.
FAU - Alexandrides, Theodoros
AU  - Alexandrides T
AD  - Division of Endocrinology, Department of Medicine, University General Hospital of 
      Patras, Patras, Greece.
FAU - Elisaf, Moses
AU  - Elisaf M
AD  - School of Health Sciences, Faculty of Medicine, Department of Internal Medicine, 
      University of Ioannina, Ioannina, Greece.
FAU - Melidonis, Andreas
AU  - Melidonis A
AD  - Diabetic Center, General Hospital "Tzanio", Piraeus, Greece.
FAU - Bousboulas, Stavros
AU  - Bousboulas S
AD  - Diabetic Center, General Hospital "Ag. Panteleimon", Piraeus, Greece.
FAU - Thanopoulou, Anastasia
AU  - Thanopoulou A
AD  - Diabetes Center, 2nd Department of Internal Medicine, Medical School, National 
      and Kapodistrian University of Athens, Hippokratio General Hospital, Athens, 
      Greece.
FAU - Pagkalos, Emmanouil M
AU  - Pagkalos EM
AD  - Diabetes Department, Thermi Clinic, Thessaloniki, Greece.
FAU - Avramidis, Iakovos
AU  - Avramidis I
AD  - First Medical Department, G. Papanikolaou General Hospital, Thessaloniki, Greece.
FAU - Pappas, Angelos
AU  - Pappas A
AD  - Diabetic Center, Venizelio General Hospital Heraklion, Crete, Greece.
FAU - Arvaniti, Eleni
AU  - Arvaniti E
AD  - General Hospital of Ioannina "G. Hatzikosta", Ioannina, Greece.
FAU - Karamousouli, Eugenia
AU  - Karamousouli E
AD  - MSD, Athens, Greece.
FAU - Voss, Bernd
AU  - Voss B
AD  - MSD RBSC GmbH, Haar, Germany.
FAU - Tentolouris, Nikolaos
AU  - Tentolouris N
AD  - 1st Department of Propaedeutic Internal Medicine, Medical School, National and 
      Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.
LA  - eng
PT  - Journal Article
DEP - 20190620
PL  - United States
TA  - Diabetes Ther
JT  - Diabetes therapy : research, treatment and education of diabetes and related 
      disorders
JID - 101539025
PMC - PMC6612340
OTO - NOTNLM
OT  - Oral glucose-lowering agents
OT  - Systematic education program
OT  - Telephone support
OT  - Treatment adherence
OT  - Treatment satisfaction
OT  - Type 2 diabetes
EDAT- 2019/06/22 06:00
MHDA- 2019/06/22 06:01
PMCR- 2019/06/20
CRDT- 2019/06/22 06:00
PHST- 2019/04/02 00:00 [received]
PHST- 2019/06/22 06:00 [pubmed]
PHST- 2019/06/22 06:01 [medline]
PHST- 2019/06/22 06:00 [entrez]
PHST- 2019/06/20 00:00 [pmc-release]
AID - 10.1007/s13300-019-0648-9 [pii]
AID - 648 [pii]
AID - 10.1007/s13300-019-0648-9 [doi]
PST - ppublish
SO  - Diabetes Ther. 2019 Aug;10(4):1407-1422. doi: 10.1007/s13300-019-0648-9. Epub 
      2019 Jun 20.