PMID- 31222661
OWN - NLM
STAT- MEDLINE
DCOM- 20200101
LR  - 20200225
IS  - 1573-5168 (Electronic)
IS  - 0920-1742 (Linking)
VI  - 45
IP  - 4
DP  - 2019 Aug
TI  - DNA damage and physiological responses in an Indian major carp Labeo rohita 
      exposed to an antimicrobial agent triclosan.
PG  - 1463-1484
LID - 10.1007/s10695-019-00661-2 [doi]
AB  - This study is aimed to evaluate the toxic effects of triclosan (TCS) in an Indian 
      major carp Labeo rohita. The 96-h LC(50) value of triclosan to L. rohita was 
      found to be 0.39 mg L(-1). Fish were exposed to two sublethal concentrations 
      (0.039 mg L(-1), treatment I and 0.078 mg L(-1), treatment II) of TCS for 
      35 days, and certain hematobiochemical, antioxidant, histopathological responses 
      were measured. Compared to the control group, there was a significant (p < 0.05) 
      decrease in the values and genotoxicity of hematological parameters such as 
      hemoglobin (Hb), hematocrit (Hct), and erythrocyte (RBC) in TCS-exposed fish, but 
      the values of leucocyte count (WBC), mean corpuscular volume (MCV), and mean 
      corpuscular hemoglobin (MCH) were found to be increased. A biphasic response in 
      mean corpuscular hemoglobin concentration (MCHC) value was observed during the 
      study period (35 days). Significant (p < 0.05) alterations in plasma biochemical 
      parameters (glucose and protein), electrolytes (Na(+), K(+), and Cl(-)), and 
      transaminases (GOT and GPT) were observed in fish treated with TCS in both 
      treatments. Gill Na(+)/K(+)-ATPase activity was found to be decreased in fish 
      treated with TCS in both treatments. Enzymatic and nonenzymatic antioxidant index 
      levels have also fluctuated in all the tissues (gill, liver, and kidney). The 
      histological lesions were comparatively more severe in the gill than the liver 
      and kidney. Comet assay showed DNA damage on exposure at two sublethal 
      concentrations. The present results suggest that TCS is highly toxic to fish even 
      at sublethal concentrations.
FAU - Hemalatha, Devan
AU  - Hemalatha D
AD  - Department of Zoology, PSG Arts and Science College, Avinashi Road, Civil 
      Aerodrome Post, Coimbatore, Tamil Nadu, 641014, India.
FAU - Nataraj, Bojan
AU  - Nataraj B
AD  - Unit of Toxicology, Department of Zoology, School of Life Sciences, Bharathiar 
      University, Coimbatore, Tamil Nadu, 641046, India.
FAU - Rangasamy, Basuvannan
AU  - Rangasamy B
AD  - Unit of Toxicology, Department of Zoology, School of Life Sciences, Bharathiar 
      University, Coimbatore, Tamil Nadu, 641046, India.
FAU - Shobana, Chellappan
AU  - Shobana C
AD  - Unit of Toxicology, Department of Zoology, School of Life Sciences, Bharathiar 
      University, Coimbatore, Tamil Nadu, 641046, India.
FAU - Ramesh, Mathan
AU  - Ramesh M
AUID- ORCID: 0000-0001-9096-8274
AD  - Department of Zoology, PSG Arts and Science College, Avinashi Road, Civil 
      Aerodrome Post, Coimbatore, Tamil Nadu, 641014, India. mathanramesh@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20190620
PL  - Netherlands
TA  - Fish Physiol Biochem
JT  - Fish physiology and biochemistry
JID - 100955049
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Fish Proteins)
RN  - 0 (Water Pollutants, Chemical)
RN  - 4NM5039Y5X (Triclosan)
RN  - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
SB  - IM
MH  - Animals
MH  - Anti-Infective Agents/*toxicity
MH  - *Cyprinidae/genetics/metabolism
MH  - DNA Damage
MH  - Fish Proteins/metabolism
MH  - Gills/drug effects/metabolism
MH  - Hematologic Tests
MH  - Kidney/drug effects/metabolism
MH  - Lethal Dose 50
MH  - Liver/drug effects/metabolism
MH  - Sodium-Potassium-Exchanging ATPase/metabolism
MH  - Triclosan/*toxicity
MH  - Water Pollutants, Chemical/*toxicity
OTO - NOTNLM
OT  - Biomarkers
OT  - Comet assay
OT  - Labeo rohita
OT  - Oxidative stress
OT  - Sublethal
OT  - Triclosan
EDAT- 2019/06/22 06:00
MHDA- 2020/01/02 06:00
CRDT- 2019/06/22 06:00
PHST- 2018/09/18 00:00 [received]
PHST- 2019/05/20 00:00 [accepted]
PHST- 2019/06/22 06:00 [pubmed]
PHST- 2020/01/02 06:00 [medline]
PHST- 2019/06/22 06:00 [entrez]
AID - 10.1007/s10695-019-00661-2 [pii]
AID - 10.1007/s10695-019-00661-2 [doi]
PST - ppublish
SO  - Fish Physiol Biochem. 2019 Aug;45(4):1463-1484. doi: 10.1007/s10695-019-00661-2. 
      Epub 2019 Jun 20.