PMID- 31222873
OWN - NLM
STAT- MEDLINE
DCOM- 20200518
LR  - 20200518
IS  - 1529-8027 (Electronic)
IS  - 1085-9489 (Linking)
VI  - 24
IP  - 3
DP  - 2019 Sep
TI  - Sensory ataxia rating scale: Development and validation of a functional scale for 
      patients with sensory neuronopathies.
PG  - 242-246
LID - 10.1111/jns.12330 [doi]
AB  - Sensory neuronopathies (SN) result from dorsal root ganglia damage and manifest 
      with a combination of sensory deficits and proprioceptive ataxia. 
      Characterization of the natural history and development of therapeutic trials are 
      hampered by the lack of clinical scales that capture the whole spectrum of 
      SN-related manifestations. We propose and validate a rating instrument for SN. 
      Three experienced neuromuscular specialists developed items to rate SN. The 
      resultant instrument was later validated by the assessment of the intra-class 
      correlation coefficient, for inter-rater validity in 48 SN patients, and later in 
      a smaller subset of 16 patients to assess its intra-rater validity. Standardized 
      Crombach's alpha and Oblimin rotation analysis were performed to verify internal 
      consistency and items' relationship, respectively. Evaluation of Sensory Ataxia 
      Rating Scale (SEARS)'s external validity was performed by comparison to: scale 
      for the assessment and rating of ataxia (SARA), Beck balance scale (BBS), and 
      INCAT sensory sum score (ISS). A 10-item scale with an intra-class correlation 
      coefficient >0.95 for intra- and inter-rating measurements with a good internal 
      consistency (standardized Cronbach's alpha of 0.83) were observed. There was a 
      normal distribution of the scores without a floor or ceiling effect. A moderate 
      to good correlation between SEARS and SARA, BBS, and ISS was observed. SEARS is a 
      reliable, easy-to-perform and consistent instrument to rate SN. Larger cohorts 
      and multicenter studies are needed to validate its usefulness towards possible 
      treatment trials.
CI  - (c) 2019 Peripheral Nerve Society.
FAU - Martinez, Alberto R M
AU  - Martinez ARM
AUID- ORCID: 0000-0001-7160-0853
AD  - Department of Neurology - Neuromuscular Division, University of Campinas 
      (UNICAMP), Campinas, Brazil.
FAU - Martins, Melina P
AU  - Martins MP
AD  - Department of Neurology - Neuromuscular Division, University of Campinas 
      (UNICAMP), Campinas, Brazil.
FAU - Martins, Carlos R Jr
AU  - Martins CR Jr
AD  - Department of Neurology - Neuromuscular Division, University of Campinas 
      (UNICAMP), Campinas, Brazil.
FAU - Faber, Ingrid
AU  - Faber I
AD  - Department of Neurology - Neuromuscular Division, University of Campinas 
      (UNICAMP), Campinas, Brazil.
FAU - de Rezende, Thiago J R
AU  - de Rezende TJR
AD  - Department of Neurology - Neuromuscular Division, University of Campinas 
      (UNICAMP), Campinas, Brazil.
FAU - Nucci, Anamarli
AU  - Nucci A
AD  - Department of Neurology - Neuromuscular Division, University of Campinas 
      (UNICAMP), Campinas, Brazil.
FAU - Franca, Marcondes C Jr
AU  - Franca MC Jr
AD  - Department of Neurology - Neuromuscular Division, University of Campinas 
      (UNICAMP), Campinas, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20190708
PL  - United States
TA  - J Peripher Nerv Syst
JT  - Journal of the peripheral nervous system : JPNS
JID - 9704532
SB  - IM
MH  - Adult
MH  - Aged
MH  - Ataxia/*diagnosis/physiopathology
MH  - Disability Evaluation
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychometrics
MH  - Reproducibility of Results
MH  - Severity of Illness Index
MH  - Symptom Assessment
OTO - NOTNLM
OT  - SEARS
OT  - clinical scale
OT  - ganglionopathy
OT  - rating scale
OT  - sensory ataxia
OT  - sensory neuronopathy
EDAT- 2019/06/22 06:00
MHDA- 2020/05/19 06:00
CRDT- 2019/06/22 06:00
PHST- 2019/05/03 00:00 [received]
PHST- 2019/06/16 00:00 [revised]
PHST- 2019/06/17 00:00 [accepted]
PHST- 2019/06/22 06:00 [pubmed]
PHST- 2020/05/19 06:00 [medline]
PHST- 2019/06/22 06:00 [entrez]
AID - 10.1111/jns.12330 [doi]
PST - ppublish
SO  - J Peripher Nerv Syst. 2019 Sep;24(3):242-246. doi: 10.1111/jns.12330. Epub 2019 
      Jul 8.