PMID- 3122356
OWN - NLM
STAT- MEDLINE
DCOM- 19880202
LR  - 20190727
IS  - 0049-3848 (Print)
IS  - 0049-3848 (Linking)
VI  - 48
IP  - 1
DP  - 1987 Oct 1
TI  - Acute myocardial infarction: measurement of arachidonate end-products in whole 
      blood as an index of platelet cyclo-oxygenase activity in vivo.
PG  - 63-71
AB  - The endogenous arachidonic acid metabolism was investigated ex vivo, in separated 
      serum from clotted whole blood, soon after the onset of acute myocardial 
      infarction (3.3 +/- 0.7 hr). A group of eight consecutive male patients was 
      selected, since no evidence was obtained of any associated disease known to 
      increase platelet activity or any recent exposure to cyclo-oxygenase inhibitors. 
      This group of patients compared to an age and sex matched control group showed a 
      large decrease in the platelet cyclo-oxygenase end-products in whole blood: 
      thromboxane B2 (TXB2), 12-hydroxy-5-cis, 8-cis, 10-trans-heptadecatrienoic acid 
      (HHT) and 6-keto-PGF1 alpha (p less than .01). In addition, platelet lipoxygenase 
      produced an increased amount of 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid 
      (12-HPETE) as measured by its reduced metabolite 12-HETE (p less than .05). 
      Furthermore, the TXB2 plasma concentration was significantly elevated in patients 
      (p less than .01), confirming the enhanced platelet reactivity during the early 
      stages of acute myocardial infarction. These results point out that a decreased 
      level of cyclo-oxygenase end-products and an increased level of lipoxygenase 
      end-product in serum is consistent with a previous in vivo cyclo-oxygenase 
      hyperactivity.
FAU - Rousson, D
AU  - Rousson D
AD  - Institut Pasteur, INSERM U63, Faculte Alexis Carrel, Lyon, France.
FAU - Lagarde, M
AU  - Lagarde M
FAU - Touboul, P
AU  - Touboul P
FAU - Dechavanne, M
AU  - Dechavanne M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
RN  - 0 (Arachidonic Acids)
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 0 (Hydroxyeicosatetraenoic Acids)
RN  - 27YG812J1I (Arachidonic Acid)
RN  - 50683-78-8 (12-hydroxy-5,8,10-heptadecatrienoic acid)
RN  - 54397-85-2 (Thromboxane B2)
RN  - 58962-34-8 (6-Ketoprostaglandin F1 alpha)
RN  - 59985-28-3 (12-Hydroxy-5,8,10,14-eicosatetraenoic Acid)
RN  - EC 1.13.11.12 (Lipoxygenase)
RN  - EC 1.14.99.1 (Prostaglandin-Endoperoxide Synthases)
SB  - IM
MH  - 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
MH  - 6-Ketoprostaglandin F1 alpha/blood
MH  - Arachidonic Acid
MH  - Arachidonic Acids/*metabolism
MH  - Blood Platelets/*enzymology
MH  - Fatty Acids, Unsaturated/blood
MH  - Humans
MH  - Hydroxyeicosatetraenoic Acids/blood
MH  - Lipoxygenase/metabolism
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*blood/metabolism
MH  - Prostaglandin-Endoperoxide Synthases/*metabolism
MH  - Thromboxane B2/blood
EDAT- 1987/10/01 00:00
MHDA- 1987/10/01 00:01
CRDT- 1987/10/01 00:00
PHST- 1987/10/01 00:00 [pubmed]
PHST- 1987/10/01 00:01 [medline]
PHST- 1987/10/01 00:00 [entrez]
AID - 0049-3848(87)90346-X [pii]
AID - 10.1016/0049-3848(87)90346-x [doi]
PST - ppublish
SO  - Thromb Res. 1987 Oct 1;48(1):63-71. doi: 10.1016/0049-3848(87)90346-x.