PMID- 31225575 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20191206 LR - 20191217 IS - 1477-0539 (Electronic) IS - 1477-0520 (Linking) VI - 17 IP - 26 DP - 2019 Jul 14 TI - Dehydrogenative C(sp(3))-H bond functionalization of tetrahydroisoquinolines mediated by organic oxidants under mild conditions. PG - 6420-6425 LID - 10.1039/c9ob01090d [doi] AB - The organocatalyzed Mannich reaction of unsubstituted and N-aryl-substituted tetrahydroisoquinolines (THIQs) and the Strecker reaction of several N-aryl-substituted THIQs through dehydrogenative C(sp3)-H bond functionalization (cross-dehydrogenative coupling) promoted by organic single electron oxidants DDQ and IBX are presented. The C-H oxidation/Mannich reaction of less reactive N-aryl substituted pyrrolidines is achieved via metal catalyzed photoredox catalysis. Operationally simple procedures provide desired products in an effective and time preserving manner. FAU - DZambaski, Zdravko AU - DZambaski Z AD - Center for Chemistry, ICTM institute, University of Belgrade, Njegoseva 12, 11 000 Belgrade, Serbia. bbondzic@chem.bg.ac.rs. FAU - BondZic, Bojan P AU - BondZic BP AUID- ORCID: 0000-0002-8249-6091 AD - Center for Chemistry, ICTM institute, University of Belgrade, Njegoseva 12, 11 000 Belgrade, Serbia. bbondzic@chem.bg.ac.rs. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190621 PL - England TA - Org Biomol Chem JT - Organic & biomolecular chemistry JID - 101154995 SB - IM EDAT- 2019/06/22 06:00 MHDA- 2019/06/22 06:01 CRDT- 2019/06/22 06:00 PHST- 2019/06/22 06:00 [pubmed] PHST- 2019/06/22 06:01 [medline] PHST- 2019/06/22 06:00 [entrez] AID - 10.1039/c9ob01090d [doi] PST - ppublish SO - Org Biomol Chem. 2019 Jul 14;17(26):6420-6425. doi: 10.1039/c9ob01090d. Epub 2019 Jun 21.