PMID- 31225769
OWN - NLM
STAT- MEDLINE
DCOM- 20191213
LR  - 20191217
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Linking)
VI  - 22
IP  - 7
DP  - 2019 Jul
TI  - Aster glehni Extract Ameliorates Scopolamine-Induced Cognitive Impairment in 
      Mice.
PG  - 685-695
LID - 10.1089/jmf.2018.4302 [doi]
AB  - The leaves of Aster glehni Fr. Schm. (Asteraceae) have been used to treat 
      insomnia in Korea. Insomnia is a common adverse effect of therapeutic agents for 
      Alzheimer's disease (AD), and the control of sleep disturbance may prevent 
      dementia. We hypothesized that the leaves of A. glehni can attenuate cognitive 
      dysfunctions observed in AD. We observed the ameliorating effects of the 
      ethanolic extract of leaves of A. glehni (AG-D) on memory dysfunction through the 
      Morris water maze test, the passive avoidance test, and the Y-maze test. We 
      performed acetylcholinesterase (AChE) activity assay and Western blotting to 
      determine the mechanism of action of AG-D. AG-D significantly attenuated memory 
      dysfunction observed in the above behavior studies and inhibited the activity of 
      AChE. AG-D also increased the levels of phosphorylation extracellular 
      signal-regulated kinase (ERK), cAMP response element-binding protein (CREB), 
      phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt), and glycogen 
      synthase kinase 3beta (GSK-3beta) and the expression levels of brain-derived 
      neurotrophic factor (BDNF) in the hippocampi. These results suggest that AG-D 
      ameliorates memory impairments by AChE inhibition and activation of ERK-CREB-BDNF 
      and PI3K-Akt-GSK-3beta signaling pathways. Taken together, this study suggests that 
      AG-D could be used as a potential treatment for cognitive dysfunction.
FAU - Liao, Yulan
AU  - Liao Y
AD  - 1 Department of Life and Nanopharmaceutical Science and College of Pharmacy, 
      Kyung Hee University, Seoul, Korea.
FAU - Bae, Ho Jung
AU  - Bae HJ
AD  - 1 Department of Life and Nanopharmaceutical Science and College of Pharmacy, 
      Kyung Hee University, Seoul, Korea.
FAU - Park, Jong Hun
AU  - Park JH
AD  - 2 Graduate School of East-West Medical Science, Kyung Hee University, Yongin, 
      Korea.
FAU - Zhang, Jiabao
AU  - Zhang J
AD  - 1 Department of Life and Nanopharmaceutical Science and College of Pharmacy, 
      Kyung Hee University, Seoul, Korea.
FAU - Koo, Bokyung
AU  - Koo B
AD  - 1 Department of Life and Nanopharmaceutical Science and College of Pharmacy, 
      Kyung Hee University, Seoul, Korea.
FAU - Lim, Mi Kyung
AU  - Lim MK
AD  - 3 Department of R&D Center, Koreaeundan, Seongnam, Korea.
FAU - Han, Eun Hye
AU  - Han EH
AD  - 3 Department of R&D Center, Koreaeundan, Seongnam, Korea.
FAU - Lee, Sang Ho
AU  - Lee SH
AD  - 3 Department of R&D Center, Koreaeundan, Seongnam, Korea.
FAU - Jung, Seo Yun
AU  - Jung SY
AD  - 1 Department of Life and Nanopharmaceutical Science and College of Pharmacy, 
      Kyung Hee University, Seoul, Korea.
FAU - Lew, Jae Hwan
AU  - Lew JH
AD  - 2 Graduate School of East-West Medical Science, Kyung Hee University, Yongin, 
      Korea.
FAU - Ryu, Jong Hoon
AU  - Ryu JH
AD  - 1 Department of Life and Nanopharmaceutical Science and College of Pharmacy, 
      Kyung Hee University, Seoul, Korea.
AD  - 4 Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee 
      University, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20190621
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Plant Extracts)
RN  - DL48G20X8X (Scopolamine)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
SB  - IM
MH  - Acetylcholinesterase/genetics/metabolism
MH  - Animals
MH  - Aster Plant/*chemistry
MH  - Cognitive Dysfunction/chemically induced/*drug therapy/metabolism/psychology
MH  - Cyclic AMP Response Element-Binding Protein/genetics/metabolism
MH  - Hippocampus/drug effects/metabolism
MH  - Humans
MH  - Male
MH  - Maze Learning
MH  - Memory/drug effects
MH  - Mice
MH  - Phosphatidylinositol 3-Kinases/genetics/metabolism
MH  - Plant Extracts/*administration & dosage
MH  - Scopolamine/adverse effects
MH  - Signal Transduction/drug effects
EDAT- 2019/06/22 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/06/22 06:00
PHST- 2019/06/22 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/06/22 06:00 [entrez]
AID - 10.1089/jmf.2018.4302 [doi]
PST - ppublish
SO  - J Med Food. 2019 Jul;22(7):685-695. doi: 10.1089/jmf.2018.4302. Epub 2019 Jun 21.