PMID- 31226227
OWN - NLM
STAT- MEDLINE
DCOM- 20191025
LR  - 20220410
IS  - 1097-0010 (Electronic)
IS  - 0022-5142 (Linking)
VI  - 99
IP  - 14
DP  - 2019 Nov
TI  - Residue behaviours, dissipation kinetics and dietary risk assessment of 
      pyaclostrobin, cyazofamid and its metabolite in grape.
PG  - 6167-6172
LID - 10.1002/jsfa.9877 [doi]
AB  - BACKGROUND: Grape is an important fruit consumed either fresh or processed, 
      therefore, fungicide misuse of grape has become an issue of global food safety 
      and human health. Pyraclostrobin, and cyazofamid have been applied to grape 
      frequently. RESULTS: Here a simple QuEChERS (quick, easy, cheap, effective, 
      rugged, and safe) liquid chromatography mass spectrometry technique has been 
      developed and validated for the determination of pyraclostrobin, cyazofamid and 
      its metabolite CCIM in open field grape samples. The recoveries of these three in 
      the range of 0.01 to 5 mg kg(-1) (n = 5) ranged from 73.1% to 97.9%. The relative 
      standard deviations (RSDs) were below 12% for all cases. The limits of 
      quantitation of each analyte was 0.005 mg kg(-1) , which was lower than maximum 
      residue limits of not only pyraclostrobin but also cyazofamid. Not only 
      dissipation kinetics but also residue determination was obtained in grape for 
      those three pesticides. Furthermore, their half-lives in grapes were 10.7-30.1 
      days, recommending the pre-harvest intervals for these three of 14 days. The 
      calculated hazard quotient and acute hazard index lower than 100% illustrated the 
      safety of intake of grape for the Chinese population for not only long-term but 
      also short-term dietary risk assessment. CONSLUSIONS: The less than 30 day 
      half-life illustrated that pyraclostrobin and cyazofamid could degrade relatively 
      easily in the environment. The long-term and short-term dietary risk assessment 
      also illustrated the intake safety of these three. Thus, a 14 day pre-harvest 
      interval was safe and recommended. The results of this study contributed to 
      environmental protection, food safety and human health. (c) 2019 Society of 
      Chemical Industry.
CI  - (c) 2019 Society of Chemical Industry.
FAU - Pang, Nannan
AU  - Pang N
AD  - Laboratory of Pesticide Residues and Environmental Toxicology, School of 
      Chemistry and Biological Engineering, University of Science and Technology 
      Beijing, Beijing, P. R. China.
FAU - Dou, Xinyu
AU  - Dou X
AD  - Laboratory of Pesticide Residues and Environmental Toxicology, School of 
      Chemistry and Biological Engineering, University of Science and Technology 
      Beijing, Beijing, P. R. China.
FAU - Hu, Jiye
AU  - Hu J
AUID- ORCID: 0000-0001-9365-5847
AD  - Laboratory of Pesticide Residues and Environmental Toxicology, School of 
      Chemistry and Biological Engineering, University of Science and Technology 
      Beijing, Beijing, P. R. China.
LA  - eng
GR  - China Scholarship Council/
PT  - Journal Article
DEP - 20190826
PL  - England
TA  - J Sci Food Agric
JT  - Journal of the science of food and agriculture
JID - 0376334
RN  - 0 (Fungicides, Industrial)
RN  - 0 (Imidazoles)
RN  - 0 (Strobilurins)
RN  - 0 (Sulfonamides)
RN  - DJW8M9OX1H (pyrachlostrobin)
RN  - QJC4S2YQ4B (cyazofamid)
SB  - IM
MH  - China
MH  - Consumer Product Safety
MH  - Drug Residues/*chemistry/metabolism
MH  - Food Contamination/analysis
MH  - Fruit/chemistry
MH  - Fungicides, Industrial/*chemistry/metabolism
MH  - Half-Life
MH  - Humans
MH  - Imidazoles/*chemistry/metabolism
MH  - Kinetics
MH  - Risk Assessment
MH  - Strobilurins/*chemistry/metabolism
MH  - Sulfonamides/*chemistry/metabolism
MH  - Tandem Mass Spectrometry
MH  - Vitis/*chemistry/metabolism
OTO - NOTNLM
OT  - CCIM
OT  - cyazofamid
OT  - dietary risk assessment
OT  - dissipation kinetics
OT  - mass spectrometry
OT  - pyraclostrobin
EDAT- 2019/06/22 06:00
MHDA- 2019/10/28 06:00
CRDT- 2019/06/22 06:00
PHST- 2019/01/20 00:00 [received]
PHST- 2019/05/14 00:00 [revised]
PHST- 2019/06/14 00:00 [accepted]
PHST- 2019/06/22 06:00 [pubmed]
PHST- 2019/10/28 06:00 [medline]
PHST- 2019/06/22 06:00 [entrez]
AID - 10.1002/jsfa.9877 [doi]
PST - ppublish
SO  - J Sci Food Agric. 2019 Nov;99(14):6167-6172. doi: 10.1002/jsfa.9877. Epub 2019 
      Aug 26.