PMID- 31228159
OWN - NLM
STAT- MEDLINE
DCOM- 20191113
LR  - 20191113
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 2018
DP  - 2019
TI  - Networking in Biology: The Hybrid Rat Diversity Panel.
PG  - 213-231
LID - 10.1007/978-1-4939-9581-3_10 [doi]
AB  - One of the most fruitful resources for systems genetic studies of nonhuman 
      mammals is a panel of inbred strains that exhibits significant genetic diversity 
      between strains but genetic stability (isogenicity) within strains. These 
      characteristics allow for fine mapping of complex phenotypes (QTLs) and provide 
      statistical power to identify loci which contribute nominally to the phenotype. 
      This type of resource also allows the planning and performance of investigations 
      using the same genetic backgrounds over several generations of the test animals. 
      Often, rats are preferred over mice for physiologic and behavioral studies 
      because of their larger size and more distinguishable anatomy (particularly for 
      their central nervous system). The Hybrid Rat Diversity Panel (HRDP) is a panel 
      of inbred rat strains, which combines two recombinant inbred panels (the HXB/BXH, 
      30 strains; the LEXF/FXLE, 34 strains and 35 more strains of inbred rats which 
      were selected for genetic diversity, based on their fully sequenced genomes 
      and/or thorough genotyping). The genetic diversity and statistical power of this 
      panel for mapping studies rivals or surpasses currently available panels in 
      mouse. The genetic stability of this panel makes it particularly suitable for 
      collection of high-throughput omics data as relevant technology becomes available 
      for engaging in truly integrative systems biology. The PhenoGen website ( 
      http://phenogen.org ) is the repository for the initial transcriptome data, 
      making the raw data, the processed data, and the analysis results, e.g., 
      organ-specific protein coding and noncoding transcripts, isoform analysis, 
      expression quantitative trait loci, and co-expression networks, available to the 
      research public. The data sets and tools being developed will complement current 
      efforts to analyze the human transcriptome and its genetic controls (the 
      Genotype-Tissue Expression Project (GTEx)) and allow for dissection of genetic 
      networks that predispose to particular phenotypes and gene-by-environment 
      interactions that are difficult or even impossible to study in humans. The HRDP 
      is an essential population for exploring truly integrative systems genetics.
FAU - Tabakoff, Boris
AU  - Tabakoff B
AD  - Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and 
      Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA.
FAU - Smith, Harry
AU  - Smith H
AD  - Department of Biostatistics and Informatics, Colorado School of Public Health, 
      University of Colorado, Aurora, CO, USA.
FAU - Vanderlinden, Lauren A
AU  - Vanderlinden LA
AD  - Department of Biostatistics and Informatics, Colorado School of Public Health, 
      University of Colorado, Aurora, CO, USA.
FAU - Hoffman, Paula L
AU  - Hoffman PL
AD  - Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and 
      Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA.
AD  - Department of Pharmacology, School of Medicine, University of Colorado Anschutz 
      Medical Campus, Aurora, CO, USA.
FAU - Saba, Laura M
AU  - Saba LM
AD  - Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and 
      Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA. 
      Laura.Saba@ucdenver.edu.
LA  - eng
GR  - R24 AA013162/AA/NIAAA NIH HHS/United States
GR  - P30 DA044223/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - Animals
MH  - Chimera/genetics
MH  - Gene Regulatory Networks
MH  - *Genetic Variation
MH  - Humans
MH  - Models, Animal
MH  - Quantitative Trait Loci
MH  - Rats
MH  - Rats, Inbred Strains/*genetics
MH  - Software
MH  - Systems Biology/*methods
MH  - Whole Genome Sequencing
OTO - NOTNLM
OT  - Co-expression networks
OT  - Expression quantitative trait loci
OT  - Genetically renewable rodent panel
OT  - Hybrid Rat Diversity Panel
OT  - Noncoding transcripts
OT  - Systems genetics
EDAT- 2019/06/23 06:00
MHDA- 2019/11/14 06:00
CRDT- 2019/06/23 06:00
PHST- 2019/06/23 06:00 [entrez]
PHST- 2019/06/23 06:00 [pubmed]
PHST- 2019/11/14 06:00 [medline]
AID - 10.1007/978-1-4939-9581-3_10 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2019;2018:213-231. doi: 10.1007/978-1-4939-9581-3_10.