PMID- 31228482
OWN - NLM
STAT- MEDLINE
DCOM- 20200219
LR  - 20221207
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 98
DP  - 2019 Sep
TI  - Amino acid signature predictive of incident prediabetes: A case-control study 
      nested within the longitudinal pathobiology of prediabetes in a biracial cohort.
PG  - 76-83
LID - S0026-0495(19)30126-X [pii]
LID - 10.1016/j.metabol.2019.06.011 [doi]
AB  - OBJECTIVE: Circulating branched-chain amino acids (BCAAs, isoleucine, leucine, 
      valine) and aromatic amino acids (AAAs, tyrosine and phenylalanine) predicted 
      type 2 diabetes mellitus (T2DM) risk in a Caucasian population. Here, we assessed 
      amino acid levels in relation to incident prediabetes among initially 
      normoglycemic African Americans (AA) and European Americans (EA). RESEARCH DESIGN 
      AND METHODS: Using a nested case-control design, we studied 70 adults (35 AA, 35 
      EA) who developed prediabetes (progressors) and 70 matched participants who 
      maintained normoglycemia (nonprogressors) during 5.5 years of follow-up in the 
      Pathobiology of Prediabetes in a Biracial Cohort study. Assessments included 
      plasma amino acid levels, insulin sensitivity, and beta-cell function. RESULTS: 
      The total level of all 18 amino acid assayed was significantly associated with 
      lean mass (r = 0.36, P < 0.0001), waist circumference (r = 0.27, P = 0.001), 
      fasting plasma glucose (r = 0.24, P = 0.005), HOMA-IR (r = 0.22, P = 0.01) and 
      HDL cholesterol (r = -0.18, P = 0.03). Individual amino acid levels were 
      significantly associated with insulin sensitivity and insulin secretion. Compared 
      with nonprogressors, progressors had higher baseline levels of asparagine and 
      aspartic acid (P <0.0001), glutamine/glutamic acid (P = 0.005) and phenylalanine 
      (P = 0.02), and lower histidine (P = 0.02) levels. In fully-adjusted logistic 
      regression models, aspartic acid/asparagine (OR 2.72 [95% CI 1.91-3.87]) and 
      histidine (OR 0.90 [95% CI 0.85-0.96]) were the only amino acids that 
      significantly predicted incident prediabetes. CONCLUSIONS: Baseline plasma 
      aspartic acid and asparagine levels predicted progression to prediabetes, whereas 
      histidine levels were protective of prediabetes risk. Thus, the amino acid 
      signature associated with prediabetes in a diverse population may be distinct 
      from that previously linked to T2DM in Caucasians.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Owei, Ibiye
AU  - Owei I
AD  - Division of Endocrinology, Diabetes and Metabolism, University of Tennessee 
      Health Science Center, Memphis, TN 38163, United States of America.
FAU - Umekwe, Nkiru
AU  - Umekwe N
AD  - Division of Endocrinology, Diabetes and Metabolism, University of Tennessee 
      Health Science Center, Memphis, TN 38163, United States of America.
FAU - Stentz, Frankie
AU  - Stentz F
AD  - Division of Endocrinology, Diabetes and Metabolism, University of Tennessee 
      Health Science Center, Memphis, TN 38163, United States of America.
FAU - Wan, Jim
AU  - Wan J
AD  - Department of Preventive Medicine University of Tennessee Health Science Center, 
      Memphis, TN 38163, United States of America.
FAU - Dagogo-Jack, Samuel
AU  - Dagogo-Jack S
AD  - Division of Endocrinology, Diabetes and Metabolism, University of Tennessee 
      Health Science Center, Memphis, TN 38163, United States of America. Electronic 
      address: sdj@uthsc.edu.
LA  - eng
GR  - R01 DK067269/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190619
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Amino Acids)
RN  - 0 (Blood Glucose)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 4QD397987E (Histidine)
RN  - 7006-34-0 (Asparagine)
SB  - IM
MH  - Adult
MH  - Black or African American
MH  - Amino Acids/*metabolism
MH  - Asparagine/metabolism
MH  - Aspartic Acid/metabolism
MH  - Blood Glucose/analysis
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Histidine/metabolism
MH  - Humans
MH  - Insulin Resistance
MH  - Insulin-Secreting Cells/metabolism
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Prediabetic State/*diagnosis/*metabolism
MH  - Predictive Value of Tests
MH  - Racial Groups
MH  - White People
PMC - PMC6690793
MID - NIHMS1533722
OTO - NOTNLM
OT  - Asparagine
OT  - Aspartic acid
OT  - Histidine
OT  - Impaired fasting glucose
OT  - Impaired glucose tolerance
OT  - Insulin resistance
COIS- Conflict of Interest: The authors have no conflict of interest to disclose 
      regarding the content of this manuscript.
EDAT- 2019/06/23 06:00
MHDA- 2020/02/20 06:00
PMCR- 2020/09/01
CRDT- 2019/06/23 06:00
PHST- 2019/04/12 00:00 [received]
PHST- 2019/06/14 00:00 [revised]
PHST- 2019/06/17 00:00 [accepted]
PHST- 2019/06/23 06:00 [pubmed]
PHST- 2020/02/20 06:00 [medline]
PHST- 2019/06/23 06:00 [entrez]
PHST- 2020/09/01 00:00 [pmc-release]
AID - S0026-0495(19)30126-X [pii]
AID - 10.1016/j.metabol.2019.06.011 [doi]
PST - ppublish
SO  - Metabolism. 2019 Sep;98:76-83. doi: 10.1016/j.metabol.2019.06.011. Epub 2019 Jun 
      19.