PMID- 31228726
OWN - NLM
STAT- MEDLINE
DCOM- 20200908
LR  - 20200908
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 123
DP  - 2019 Nov
TI  - Tobacco smoking and acute exercise on immune-inflammatory responses among 
      relative short and longer smoking histories.
PG  - 154754
LID - S1043-4666(19)30180-2 [pii]
LID - 10.1016/j.cyto.2019.154754 [doi]
AB  - This study examined the acute effects of combined tobacco smoking and exercise on 
      immune-inflammatory responses in smoker populations with shorter or longer 
      smoking history. The cohort comprised 14 young male adult (YSM) and 12 
      middle-aged (MSM) male active cigarette smokers matched for aerobic fitness and 
      smoking behavior. Following an initial familiarization and baseline testing 
      session, participants completed a smoking and exercise protocol. This protocol 
      involved the inhalation of two cigarettes (12 mg tar, 1 mg nicotine) within 
      15 min, and following a 10 min recovery period, 40 min of cycling at 50% peak 
      aerobic workload. Venous blood was obtained pre- and post-protocol for analysis 
      of interleukin (IL)-6, IL-1receptor antagonist (ra), IL-1beta (beta) and monocyte 
      chemoattractant protein-1 (MCP-1) and total leukocyte count. There was no 
      baseline differences between age groups for IL-6 or MCP-1 (p > 0.05), although 
      higher basal IL-1ra was evident in YSM (p < 0.05). Further, no significant 
      differences existed between groups for post-exercise IL-1ra or IL-6 responses; 
      though MSM demonstrated an elevated MCP-1 at 4 h post (p < 0.05). No 
      between-group differences for total leukocyte count, platelets, neutrophils, 
      lymphocytes or monocytes (p > 0.05) were observed; although higher concentrations 
      of basophils immediately post and 4 h post-exercise, and higher eosinophils at 
      4 h post-exercise were evident in MSM (p < 0.05). The current study highlights 
      that prolonged elevations in MCP-1, alongside leukocytosis, accompany inhalation 
      of tobacco smoke prior to exercise.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Hartmann, Tegan
AU  - Hartmann T
AD  - School of Exercise Science, Sport & Health, Charles Sturt University, Bathurst, 
      NSW 2795, Australia. Electronic address: thartmann@csu.edu.au.
FAU - Marino, Frank
AU  - Marino F
AD  - School of Exercise Science, Sport & Health, Charles Sturt University, Bathurst, 
      NSW 2795, Australia.
FAU - Duffield, Rob
AU  - Duffield R
AD  - Sport and Exercise Discipline Group, Faculty of Health, University of Technology 
      Sydney (UTS), Sydney, NSW 2070, Australia.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20190619
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - *Cytokines/blood/immunology
MH  - *Exercise
MH  - Humans
MH  - Inflammation/blood/immunology
MH  - Male
MH  - *Smoking/blood/immunology
MH  - Young Adult
OTO - NOTNLM
OT  - Cycling
OT  - Cytokines
OT  - IL-1ra
OT  - MCP-1
OT  - Smokers
EDAT- 2019/06/23 06:00
MHDA- 2020/09/09 06:00
CRDT- 2019/06/23 06:00
PHST- 2019/03/13 00:00 [received]
PHST- 2019/05/22 00:00 [revised]
PHST- 2019/06/07 00:00 [accepted]
PHST- 2019/06/23 06:00 [pubmed]
PHST- 2020/09/09 06:00 [medline]
PHST- 2019/06/23 06:00 [entrez]
AID - S1043-4666(19)30180-2 [pii]
AID - 10.1016/j.cyto.2019.154754 [doi]
PST - ppublish
SO  - Cytokine. 2019 Nov;123:154754. doi: 10.1016/j.cyto.2019.154754. Epub 2019 Jun 19.