PMID- 31229474
OWN - NLM
STAT- MEDLINE
DCOM- 20201007
LR  - 20201007
IS  - 1873-4995 (Electronic)
IS  - 0168-3659 (Linking)
VI  - 307
DP  - 2019 Aug 10
TI  - Mathematical and computational modeling of nano-engineered drug delivery systems.
PG  - 150-165
LID - S0168-3659(19)30324-4 [pii]
LID - 10.1016/j.jconrel.2019.06.014 [doi]
AB  - While the advent of nano-engineered drug delivery systems (DDSs) has revived 
      hopes for better management of a wide range of pathologies, critical appraisal of 
      the field has shown that further improvement of nanomedicine demands a 
      paradigmatic shift in design and development approaches currently employed by 
      drug developers. In this review, we portray various theoretical modeling 
      frameworks as influential tools to furnish future design and development of DDSs. 
      The rational design of nanomedicines should be premised on taking into account 
      the sui generis nature of DDSs within a multiplex biological milieu in vivo. 
      Technical limitations, however, remain a bottleneck to the faithful 
      reconstruction of such biomimetic models. Computational and mathematical modeling 
      tools have shown potential as a promising technique to broaden the horizon of 
      nanomedicine by addressing blind spots of current empirical models. Through 
      integration with modern imaging and microfluidic technologies, in silico modeling 
      is expected to expedite the clinical translation of nanomedicine.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Shamsi, Milad
AU  - Shamsi M
AD  - BioMEMS and Bioinspired Microfluidic Laboratory, University of Calgary, Calgary, 
      AB T2N 1N4, Canada; Center for BioEngineering Research and Education, University 
      of Calgary, Calgary, AB T2N 1N4, Canada.
FAU - Mohammadi, Amir
AU  - Mohammadi A
AD  - Department of Mechanical Engineering, Faculty of Engineering, Razi University, 
      67149-67346 Kermanshah, Iran.
FAU - Manshadi, Mohammad K D
AU  - Manshadi MKD
AD  - BioMEMS and Bioinspired Microfluidic Laboratory, University of Calgary, Calgary, 
      AB T2N 1N4, Canada; Center for BioEngineering Research and Education, University 
      of Calgary, Calgary, AB T2N 1N4, Canada.
FAU - Sanati-Nezhad, Amir
AU  - Sanati-Nezhad A
AD  - BioMEMS and Bioinspired Microfluidic Laboratory, University of Calgary, Calgary, 
      AB T2N 1N4, Canada; Center for BioEngineering Research and Education, University 
      of Calgary, Calgary, AB T2N 1N4, Canada. Electronic address: 
      amir.sanatinezhad@ucalgary.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190620
PL  - Netherlands
TA  - J Control Release
JT  - Journal of controlled release : official journal of the Controlled Release 
      Society
JID - 8607908
SB  - IM
MH  - Computer Simulation
MH  - Computer-Aided Design
MH  - *Drug Delivery Systems
MH  - Humans
MH  - *Models, Theoretical
MH  - Nanomedicine
MH  - Nanoparticles/*administration & dosage
OTO - NOTNLM
OT  - Drug delivery system (DDS)
OT  - In silico design
OT  - Mathematical and computational modeling
OT  - Nanomedicine
OT  - Rational design
EDAT- 2019/06/24 06:00
MHDA- 2020/10/08 06:00
CRDT- 2019/06/24 06:00
PHST- 2019/03/29 00:00 [received]
PHST- 2019/06/10 00:00 [revised]
PHST- 2019/06/12 00:00 [accepted]
PHST- 2019/06/24 06:00 [pubmed]
PHST- 2020/10/08 06:00 [medline]
PHST- 2019/06/24 06:00 [entrez]
AID - S0168-3659(19)30324-4 [pii]
AID - 10.1016/j.jconrel.2019.06.014 [doi]
PST - ppublish
SO  - J Control Release. 2019 Aug 10;307:150-165. doi: 10.1016/j.jconrel.2019.06.014. 
      Epub 2019 Jun 20.