PMID- 31229956 OWN - NLM STAT- MEDLINE DCOM- 20200309 LR - 20220309 IS - 1468-2052 (Electronic) IS - 1359-2998 (Print) IS - 1359-2998 (Linking) VI - 105 IP - 2 DP - 2020 Mar TI - Achieved oxygen saturations and retinopathy of prematurity in extreme preterms. PG - 138-144 LID - 10.1136/archdischild-2018-316464 [doi] AB - OBJECTIVE: To identify achieved oxygen saturations (SpO(2)) associated with increased risk of severe retinopathy of prematurity (ROP). DESIGN: This is a secondary analysis of the Surfactant Positive Airway Pressure and Pulse Oximetry Trial (SUPPORT)randomised controlled trial. SpO(2) was recorded up to 36 weeks' postmenstrual age. Saturations through 9 postnatal weeks were explored graphically, and logistic regression models were created to predict severe ROP. SETTING: 20 centres of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. PATIENTS: 984 surviving infants of 24-27 weeks' gestational age born in 2005-2009. INTERVENTIONS: SUPPORT targeted SpO(2) to a lower (85%-89%) or higher (91%-95%) range through 36 weeks' postmenstrual age or off respiratory support. MAIN OUTCOME MEASURES: Severe ROP defined as threshold ROP, ophthalmological surgery or bevacizumab treatment. RESULTS: There were statistically significant interactions between duration of oxygen supplementation and percentage of time in certain achieved saturation ranges. Specifically, for infants who spent at least 2 weeks on oxygen in postnatal weeks 1-5, a higher percentage of time at 91%-96% SpO(2) was associated with increased odds of severe ROP. For infants who spent at least 3 weeks on oxygen in postnatal weeks 6-9, a higher percentage of time at 97%-100% SpO(2) was associated with increased odds of severe ROP. Other significant risk factors were lower gestational age and birth weight, non-Hispanic white versus black race, prospectively defined severe illness, late-onset sepsis or meningitis, and clinical centre. CONCLUSIONS: Among extremely preterm survivors to discharge, the association between SpO(2) and severe ROP depended on the timing and duration of oxygen supplementation. CI - (c) Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Gantz, Marie G AU - Gantz MG AD - Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Institute, Durham, North Carolina, USA. FAU - Carlo, Waldemar A AU - Carlo WA AD - Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA. FAU - Finer, Neil N AU - Finer NN AD - Department of Paediatrics Neonatology, UCFD Medical Centre, San Diego, California, USA. FAU - Rich, Wade AU - Rich W AUID- ORCID: 0000-0003-1420-9828 AD - Neonatology, University of California, San Diego, California, USA. FAU - Faix, Roger G AU - Faix RG AD - Pediatrics/Neonatology, University of Utah, Salt Lake City, Utah, USA. FAU - Yoder, Bradley A AU - Yoder BA AD - Pediatrics, University of Utah, Salt Lake City, Utah, USA. FAU - Walsh, Michele C AU - Walsh MC AD - Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA. FAU - Newman, Nancy S AU - Newman NS AD - Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA. FAU - Laptook, Abbott AU - Laptook A AD - Department of Pediatrics, Women & Infants Hospital, Providence, Rhode Island, USA. FAU - Schibler, Kurt AU - Schibler K AD - Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. AD - Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. FAU - Das, Abhik AU - Das A AD - Social, Statistical and Environmental Sciences Unit, RTI International, Rockville, Maryland, USA. FAU - Higgins, Rosemary D AU - Higgins RD AD - College of Health and Human Services, George Mason University, Fairfax, Virginia, USA. CN - SUPPORT Study Group of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network LA - eng GR - U10 HD021385/HD/NICHD NIH HHS/United States GR - U10 HD021364/HD/NICHD NIH HHS/United States GR - M01 RR008084/RR/NCRR NIH HHS/United States GR - UG1 HD034216/HD/NICHD NIH HHS/United States GR - U10 HD027871/HD/NICHD NIH HHS/United States GR - UG1 HD027880/HD/NICHD NIH HHS/United States GR - UL1 RR025008/RR/NCRR NIH HHS/United States GR - U10 HD027856/HD/NICHD NIH HHS/United States GR - U10 HD021373/HD/NICHD NIH HHS/United States GR - UL1 RR024139/RR/NCRR NIH HHS/United States GR - UG1 HD087226/HD/NICHD NIH HHS/United States GR - U10 HD053124/HD/NICHD NIH HHS/United States GR - U10 HD053119/HD/NICHD NIH HHS/United States GR - UL1 TR001863/TR/NCATS NIH HHS/United States GR - U10 HD027880/HD/NICHD NIH HHS/United States GR - UG1 HD027853/HD/NICHD NIH HHS/United States GR - U10 HD040521/HD/NICHD NIH HHS/United States GR - U10 HD053109/HD/NICHD NIH HHS/United States GR - UG1 HD087229/HD/NICHD NIH HHS/United States GR - UL1 TR003167/TR/NCATS NIH HHS/United States GR - U10 HD040461/HD/NICHD NIH HHS/United States GR - M01 RR016587/RR/NCRR NIH HHS/United States GR - U10 HD040689/HD/NICHD NIH HHS/United States GR - U10 HD040492/HD/NICHD NIH HHS/United States GR - U10 HD027853/HD/NICHD NIH HHS/United States GR - U10 HD027904/HD/NICHD NIH HHS/United States GR - U10 HD021397/HD/NICHD NIH HHS/United States GR - UG1 HD027904/HD/NICHD NIH HHS/United States GR - UL1 RR025744/RR/NCRR NIH HHS/United States GR - M01 RR007122/RR/NCRR NIH HHS/United States GR - U10 HD027851/HD/NICHD NIH HHS/United States GR - U10 HD034216/HD/NICHD NIH HHS/United States GR - U10 HD036790/HD/NICHD NIH HHS/United States GR - U10 HD040498/HD/NICHD NIH HHS/United States GR - U24 HD095254/HD/NICHD NIH HHS/United States GR - U10 HD053089/HD/NICHD NIH HHS/United States GR - UL1 TR003142/TR/NCATS NIH HHS/United States GR - UL1 RR024979/RR/NCRR NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial DEP - 20190622 PL - England TA - Arch Dis Child Fetal Neonatal Ed JT - Archives of disease in childhood. Fetal and neonatal edition JID - 9501297 RN - S88TT14065 (Oxygen) SB - IM MH - Birth Weight MH - Dose-Response Relationship, Drug MH - Female MH - Gestational Age MH - Humans MH - *Infant, Extremely Premature MH - Infant, Newborn MH - Logistic Models MH - Male MH - Oximetry MH - Oxygen/*blood MH - Oxygen Inhalation Therapy/*adverse effects/*methods MH - Retinopathy of Prematurity/blood/*epidemiology/*therapy MH - Risk Factors MH - Severity of Illness Index PMC - PMC6925651 MID - NIHMS1038206 OTO - NOTNLM OT - neonatology OT - ophthalmology OT - respiratory COIS- Competing interests: None declared. FIR - Jobe, Alan H IR - Jobe AH FIR - Caplan, Michael S IR - Caplan MS FIR - Oh, William IR - Oh W FIR - Vohr, Betty R IR - Vohr BR FIR - Hensman, Angelita M IR - Hensman AM FIR - Stephens, Bonnie E IR - Stephens BE FIR - Alksninis, Barbara IR - Alksninis B FIR - Andrews, Dawn IR - Andrews D FIR - Angela, Kristen IR - Angela K FIR - Barnett, Susan IR - Barnett S FIR - Cashore, Bill IR - Cashore B FIR - Caskey, Melinda IR - Caskey M FIR - Francis, Kim IR - Francis K FIR - Gingras, Dan IR - Gingras D FIR - Gargus, Regina A IR - Gargus RA FIR - Johnson, Katharine IR - Johnson K FIR - Lainwala, Shabnam IR - Lainwala S FIR - Leach, Theresa M IR - Leach TM FIR - Leonard, Martha R IR - Leonard MR FIR - Lillie, Sarah IR - Lillie S FIR - Mehta, Kalida IR - Mehta K FIR - Moore, James R IR - Moore JR FIR - Noel, Lucy IR - Noel L FIR - Ventura, Suzy IR - Ventura S FIR - Walden, Rachel V IR - Walden RV FIR - Watson, Victoria E IR - Watson VE FIR - Fanaroff, Avroy A IR - Fanaroff AA FIR - Wilson-Costello, Deanne E IR - 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O'Shea, T Michael IR - O'Shea TM FIR - Dillard, Robert G IR - Dillard RG FIR - Washburn, Lisa K IR - Washburn LK FIR - Peters, Nancy J IR - Peters NJ FIR - Jackson, Barbara G IR - Jackson BG FIR - Chiu, Korinne IR - Chiu K FIR - Allred, Deborah Evans IR - Allred DE FIR - Goldstein, Donald J IR - Goldstein DJ FIR - Halfond, Raquel IR - Halfond R FIR - Peterson, Carroll IR - Peterson C FIR - Waldrep, Ellen L IR - Waldrep EL FIR - Welch, Cherrie D IR - Welch CD FIR - Morris, Melissa Whalen IR - Morris MW FIR - Hounshell, Gail Wiley IR - Hounshell GW FIR - Shankaran, Seetha IR - Shankaran S FIR - Sood, Beena G IR - Sood BG FIR - Pappas, Athina IR - Pappas A FIR - Bara, Rebecca IR - Bara R FIR - Billian, Elizabeth IR - Billian E FIR - Goldston, Laura A IR - Goldston LA FIR - Johnson, Mary IR - Johnson M FIR - Ehrenkranz, Richard A IR - Ehrenkranz RA FIR - Bhandari, Vineet IR - Bhandari V FIR - Jacobs, Harris C IR - Jacobs HC FIR - Cervone, Pat IR - Cervone P FIR - Gettner, Patricia IR - Gettner P FIR - Konstantino, Monica IR - Konstantino M FIR - Poulsen, Joann IR - Poulsen J FIR - Taft, Janet IR - Taft J FIR - Butler, Christine G IR - Butler CG FIR - Close, Nancy IR - Close N FIR - Gilliam, Walter IR - Gilliam W FIR - Greisman, Sheila IR - Greisman S FIR - Romano, Elaine IR - Romano E FIR - Williams, Joanne IR - Williams J EDAT- 2019/06/24 06:00 MHDA- 2020/03/10 06:00 PMCR- 2021/03/01 CRDT- 2019/06/24 06:00 PHST- 2018/10/26 00:00 [received] PHST- 2019/05/06 00:00 [revised] PHST- 2019/05/13 00:00 [accepted] PHST- 2019/06/24 06:00 [pubmed] PHST- 2020/03/10 06:00 [medline] PHST- 2019/06/24 06:00 [entrez] PHST- 2021/03/01 00:00 [pmc-release] AID - archdischild-2018-316464 [pii] AID - 10.1136/archdischild-2018-316464 [doi] PST - ppublish SO - Arch Dis Child Fetal Neonatal Ed. 2020 Mar;105(2):138-144. doi: 10.1136/archdischild-2018-316464. Epub 2019 Jun 22.