PMID- 31230461
OWN - NLM
STAT- MEDLINE
DCOM- 20200320
LR  - 20201002
IS  - 1535-7228 (Electronic)
IS  - 0002-953X (Print)
IS  - 0002-953X (Linking)
VI  - 176
IP  - 10
DP  - 2019 Oct 1
TI  - Altered Cellular White Matter But Not Extracellular Free Water on Diffusion MRI 
      in Individuals at Clinical High Risk for Psychosis.
PG  - 820-828
LID - 10.1176/appi.ajp.2019.18091044 [doi]
AB  - OBJECTIVE: Detecting brain abnormalities in clinical high-risk populations before 
      the onset of psychosis is important for tracking pathological pathways and for 
      identifying possible intervention strategies that may impede or prevent the onset 
      of psychotic disorders. Co-occurring cellular and extracellular white matter 
      alterations have previously been implicated after a first psychotic episode. The 
      authors investigated whether or not cellular and extracellular alterations are 
      already present in a predominantly medication-naive cohort of clinical high-risk 
      individuals experiencing attenuated psychotic symptoms. METHODS: Fifty 
      individuals at clinical high risk, of whom 40 were never medicated, were compared 
      with 50 healthy control subjects, group-matched for age, gender, and parental 
      socioeconomic status. 3-T multishell diffusion MRI data were obtained to estimate 
      free-water imaging white matter measures, including fractional anisotropy of 
      cellular tissue (FA(T)) and the volume fraction of extracellular free water (FW). 
      RESULTS: Significantly lower FA(T) was observed in the clinical high-risk group 
      compared with the healthy control group, but no statistically significant FW 
      alterations were observed between groups. Lower FA(T) in the clinical high-risk 
      group was significantly associated with a decline in Global Assessment of 
      Functioning Scale (GAF) score compared with highest GAF score in the previous 12 
      months. CONCLUSIONS: Cellular but not extracellular alterations characterized the 
      clinical high-risk group, especially in those who experienced a decline in 
      functioning. These cellular changes suggest an early deficit that possibly 
      reflects a predisposition to develop attenuated psychotic symptoms. In contrast, 
      extracellular alterations were not observed in this clinical high-risk sample, 
      suggesting that previously reported extracellular abnormalities may reflect an 
      acute response to psychosis, which plays a more prominent role closer to or at 
      onset of psychosis.
FAU - Tang, Yingying
AU  - Tang Y
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China (Tang, Zhang, 
      Junjie Wang, Xu, Qian, Jijun Wang); the Psychiatry Neuroimaging Laboratory, 
      Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 
      Boston (Tang, Pasternak, Kubicki, Rathi, Zhang, Zhu, Shenton); the Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 
      (Pasternak, Kubicki, Rathi, Shenton); the Institute of Mental Health, Suzhou 
      Psychiatric Hospital, Affiliated Guangji Hospital of Soochow University, Suzhou, 
      Jiangsu, China (Junjie Wang); the Department of Psychology, Florida A&M 
      University, Tallahassee (Li); the Massachusetts Mental Health Center, Public 
      Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston (Woodberry, Keshavan, Stone, Seidman); the McGovern Institute for 
      Brain Research and the Poitras Center for Affective Disorders Research, 
      Massachusetts Institute of Technology, Cambridge (Whitfield-Gabrieli); the 
      Department of Psychiatry (Niznikiewicz, McCarley) and Research and Development 
      (Shenton), Veterans Affairs Boston Healthcare System, Brockton Division, 
      Brockton, Mass.; the Institute of Psychology and Behavioral Science, Shanghai 
      Jiao Tong University, Shanghai, China (Jijun Wang); the CAS Center for Excellence 
      in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of 
      Science, China (Jijun Wang); the Department of Psychiatry, Massachusetts General 
      Hospital, Harvard Medical School, Boston (Seidman).
FAU - Pasternak, Ofer
AU  - Pasternak O
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China (Tang, Zhang, 
      Junjie Wang, Xu, Qian, Jijun Wang); the Psychiatry Neuroimaging Laboratory, 
      Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 
      Boston (Tang, Pasternak, Kubicki, Rathi, Zhang, Zhu, Shenton); the Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 
      (Pasternak, Kubicki, Rathi, Shenton); the Institute of Mental Health, Suzhou 
      Psychiatric Hospital, Affiliated Guangji Hospital of Soochow University, Suzhou, 
      Jiangsu, China (Junjie Wang); the Department of Psychology, Florida A&M 
      University, Tallahassee (Li); the Massachusetts Mental Health Center, Public 
      Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston (Woodberry, Keshavan, Stone, Seidman); the McGovern Institute for 
      Brain Research and the Poitras Center for Affective Disorders Research, 
      Massachusetts Institute of Technology, Cambridge (Whitfield-Gabrieli); the 
      Department of Psychiatry (Niznikiewicz, McCarley) and Research and Development 
      (Shenton), Veterans Affairs Boston Healthcare System, Brockton Division, 
      Brockton, Mass.; the Institute of Psychology and Behavioral Science, Shanghai 
      Jiao Tong University, Shanghai, China (Jijun Wang); the CAS Center for Excellence 
      in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of 
      Science, China (Jijun Wang); the Department of Psychiatry, Massachusetts General 
      Hospital, Harvard Medical School, Boston (Seidman).
FAU - Kubicki, Marek
AU  - Kubicki M
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China (Tang, Zhang, 
      Junjie Wang, Xu, Qian, Jijun Wang); the Psychiatry Neuroimaging Laboratory, 
      Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 
      Boston (Tang, Pasternak, Kubicki, Rathi, Zhang, Zhu, Shenton); the Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 
      (Pasternak, Kubicki, Rathi, Shenton); the Institute of Mental Health, Suzhou 
      Psychiatric Hospital, Affiliated Guangji Hospital of Soochow University, Suzhou, 
      Jiangsu, China (Junjie Wang); the Department of Psychology, Florida A&M 
      University, Tallahassee (Li); the Massachusetts Mental Health Center, Public 
      Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston (Woodberry, Keshavan, Stone, Seidman); the McGovern Institute for 
      Brain Research and the Poitras Center for Affective Disorders Research, 
      Massachusetts Institute of Technology, Cambridge (Whitfield-Gabrieli); the 
      Department of Psychiatry (Niznikiewicz, McCarley) and Research and Development 
      (Shenton), Veterans Affairs Boston Healthcare System, Brockton Division, 
      Brockton, Mass.; the Institute of Psychology and Behavioral Science, Shanghai 
      Jiao Tong University, Shanghai, China (Jijun Wang); the CAS Center for Excellence 
      in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of 
      Science, China (Jijun Wang); the Department of Psychiatry, Massachusetts General 
      Hospital, Harvard Medical School, Boston (Seidman).
FAU - Rathi, Yogesh
AU  - Rathi Y
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China (Tang, Zhang, 
      Junjie Wang, Xu, Qian, Jijun Wang); the Psychiatry Neuroimaging Laboratory, 
      Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 
      Boston (Tang, Pasternak, Kubicki, Rathi, Zhang, Zhu, Shenton); the Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 
      (Pasternak, Kubicki, Rathi, Shenton); the Institute of Mental Health, Suzhou 
      Psychiatric Hospital, Affiliated Guangji Hospital of Soochow University, Suzhou, 
      Jiangsu, China (Junjie Wang); the Department of Psychology, Florida A&M 
      University, Tallahassee (Li); the Massachusetts Mental Health Center, Public 
      Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston (Woodberry, Keshavan, Stone, Seidman); the McGovern Institute for 
      Brain Research and the Poitras Center for Affective Disorders Research, 
      Massachusetts Institute of Technology, Cambridge (Whitfield-Gabrieli); the 
      Department of Psychiatry (Niznikiewicz, McCarley) and Research and Development 
      (Shenton), Veterans Affairs Boston Healthcare System, Brockton Division, 
      Brockton, Mass.; the Institute of Psychology and Behavioral Science, Shanghai 
      Jiao Tong University, Shanghai, China (Jijun Wang); the CAS Center for Excellence 
      in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of 
      Science, China (Jijun Wang); the Department of Psychiatry, Massachusetts General 
      Hospital, Harvard Medical School, Boston (Seidman).
FAU - Zhang, Tianhong
AU  - Zhang T
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China (Tang, Zhang, 
      Junjie Wang, Xu, Qian, Jijun Wang); the Psychiatry Neuroimaging Laboratory, 
      Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 
      Boston (Tang, Pasternak, Kubicki, Rathi, Zhang, Zhu, Shenton); the Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 
      (Pasternak, Kubicki, Rathi, Shenton); the Institute of Mental Health, Suzhou 
      Psychiatric Hospital, Affiliated Guangji Hospital of Soochow University, Suzhou, 
      Jiangsu, China (Junjie Wang); the Department of Psychology, Florida A&M 
      University, Tallahassee (Li); the Massachusetts Mental Health Center, Public 
      Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston (Woodberry, Keshavan, Stone, Seidman); the McGovern Institute for 
      Brain Research and the Poitras Center for Affective Disorders Research, 
      Massachusetts Institute of Technology, Cambridge (Whitfield-Gabrieli); the 
      Department of Psychiatry (Niznikiewicz, McCarley) and Research and Development 
      (Shenton), Veterans Affairs Boston Healthcare System, Brockton Division, 
      Brockton, Mass.; the Institute of Psychology and Behavioral Science, Shanghai 
      Jiao Tong University, Shanghai, China (Jijun Wang); the CAS Center for Excellence 
      in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of 
      Science, China (Jijun Wang); the Department of Psychiatry, Massachusetts General 
      Hospital, Harvard Medical School, Boston (Seidman).
FAU - Wang, Junjie
AU  - Wang J
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China (Tang, Zhang, 
      Junjie Wang, Xu, Qian, Jijun Wang); the Psychiatry Neuroimaging Laboratory, 
      Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 
      Boston (Tang, Pasternak, Kubicki, Rathi, Zhang, Zhu, Shenton); the Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 
      (Pasternak, Kubicki, Rathi, Shenton); the Institute of Mental Health, Suzhou 
      Psychiatric Hospital, Affiliated Guangji Hospital of Soochow University, Suzhou, 
      Jiangsu, China (Junjie Wang); the Department of Psychology, Florida A&M 
      University, Tallahassee (Li); the Massachusetts Mental Health Center, Public 
      Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston (Woodberry, Keshavan, Stone, Seidman); the McGovern Institute for 
      Brain Research and the Poitras Center for Affective Disorders Research, 
      Massachusetts Institute of Technology, Cambridge (Whitfield-Gabrieli); the 
      Department of Psychiatry (Niznikiewicz, McCarley) and Research and Development 
      (Shenton), Veterans Affairs Boston Healthcare System, Brockton Division, 
      Brockton, Mass.; the Institute of Psychology and Behavioral Science, Shanghai 
      Jiao Tong University, Shanghai, China (Jijun Wang); the CAS Center for Excellence 
      in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of 
      Science, China (Jijun Wang); the Department of Psychiatry, Massachusetts General 
      Hospital, Harvard Medical School, Boston (Seidman).
FAU - Li, Huijun
AU  - Li H
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China (Tang, Zhang, 
      Junjie Wang, Xu, Qian, Jijun Wang); the Psychiatry Neuroimaging Laboratory, 
      Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 
      Boston (Tang, Pasternak, Kubicki, Rathi, Zhang, Zhu, Shenton); the Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 
      (Pasternak, Kubicki, Rathi, Shenton); the Institute of Mental Health, Suzhou 
      Psychiatric Hospital, Affiliated Guangji Hospital of Soochow University, Suzhou, 
      Jiangsu, China (Junjie Wang); the Department of Psychology, Florida A&M 
      University, Tallahassee (Li); the Massachusetts Mental Health Center, Public 
      Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston (Woodberry, Keshavan, Stone, Seidman); the McGovern Institute for 
      Brain Research and the Poitras Center for Affective Disorders Research, 
      Massachusetts Institute of Technology, Cambridge (Whitfield-Gabrieli); the 
      Department of Psychiatry (Niznikiewicz, McCarley) and Research and Development 
      (Shenton), Veterans Affairs Boston Healthcare System, Brockton Division, 
      Brockton, Mass.; the Institute of Psychology and Behavioral Science, Shanghai 
      Jiao Tong University, Shanghai, China (Jijun Wang); the CAS Center for Excellence 
      in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of 
      Science, China (Jijun Wang); the Department of Psychiatry, Massachusetts General 
      Hospital, Harvard Medical School, Boston (Seidman).
FAU - Woodberry, Kristen A
AU  - Woodberry KA
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China (Tang, Zhang, 
      Junjie Wang, Xu, Qian, Jijun Wang); the Psychiatry Neuroimaging Laboratory, 
      Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 
      Boston (Tang, Pasternak, Kubicki, Rathi, Zhang, Zhu, Shenton); the Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 
      (Pasternak, Kubicki, Rathi, Shenton); the Institute of Mental Health, Suzhou 
      Psychiatric Hospital, Affiliated Guangji Hospital of Soochow University, Suzhou, 
      Jiangsu, China (Junjie Wang); the Department of Psychology, Florida A&M 
      University, Tallahassee (Li); the Massachusetts Mental Health Center, Public 
      Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston (Woodberry, Keshavan, Stone, Seidman); the McGovern Institute for 
      Brain Research and the Poitras Center for Affective Disorders Research, 
      Massachusetts Institute of Technology, Cambridge (Whitfield-Gabrieli); the 
      Department of Psychiatry (Niznikiewicz, McCarley) and Research and Development 
      (Shenton), Veterans Affairs Boston Healthcare System, Brockton Division, 
      Brockton, Mass.; the Institute of Psychology and Behavioral Science, Shanghai 
      Jiao Tong University, Shanghai, China (Jijun Wang); the CAS Center for Excellence 
      in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of 
      Science, China (Jijun Wang); the Department of Psychiatry, Massachusetts General 
      Hospital, Harvard Medical School, Boston (Seidman).
FAU - Xu, Lihua
AU  - Xu L
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China (Tang, Zhang, 
      Junjie Wang, Xu, Qian, Jijun Wang); the Psychiatry Neuroimaging Laboratory, 
      Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 
      Boston (Tang, Pasternak, Kubicki, Rathi, Zhang, Zhu, Shenton); the Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 
      (Pasternak, Kubicki, Rathi, Shenton); the Institute of Mental Health, Suzhou 
      Psychiatric Hospital, Affiliated Guangji Hospital of Soochow University, Suzhou, 
      Jiangsu, China (Junjie Wang); the Department of Psychology, Florida A&M 
      University, Tallahassee (Li); the Massachusetts Mental Health Center, Public 
      Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston (Woodberry, Keshavan, Stone, Seidman); the McGovern Institute for 
      Brain Research and the Poitras Center for Affective Disorders Research, 
      Massachusetts Institute of Technology, Cambridge (Whitfield-Gabrieli); the 
      Department of Psychiatry (Niznikiewicz, McCarley) and Research and Development 
      (Shenton), Veterans Affairs Boston Healthcare System, Brockton Division, 
      Brockton, Mass.; the Institute of Psychology and Behavioral Science, Shanghai 
      Jiao Tong University, Shanghai, China (Jijun Wang); the CAS Center for Excellence 
      in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of 
      Science, China (Jijun Wang); the Department of Psychiatry, Massachusetts General 
      Hospital, Harvard Medical School, Boston (Seidman).
FAU - Qian, Zhenying
AU  - Qian Z
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China (Tang, Zhang, 
      Junjie Wang, Xu, Qian, Jijun Wang); the Psychiatry Neuroimaging Laboratory, 
      Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 
      Boston (Tang, Pasternak, Kubicki, Rathi, Zhang, Zhu, Shenton); the Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 
      (Pasternak, Kubicki, Rathi, Shenton); the Institute of Mental Health, Suzhou 
      Psychiatric Hospital, Affiliated Guangji Hospital of Soochow University, Suzhou, 
      Jiangsu, China (Junjie Wang); the Department of Psychology, Florida A&M 
      University, Tallahassee (Li); the Massachusetts Mental Health Center, Public 
      Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston (Woodberry, Keshavan, Stone, Seidman); the McGovern Institute for 
      Brain Research and the Poitras Center for Affective Disorders Research, 
      Massachusetts Institute of Technology, Cambridge (Whitfield-Gabrieli); the 
      Department of Psychiatry (Niznikiewicz, McCarley) and Research and Development 
      (Shenton), Veterans Affairs Boston Healthcare System, Brockton Division, 
      Brockton, Mass.; the Institute of Psychology and Behavioral Science, Shanghai 
      Jiao Tong University, Shanghai, China (Jijun Wang); the CAS Center for Excellence 
      in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of 
      Science, China (Jijun Wang); the Department of Psychiatry, Massachusetts General 
      Hospital, Harvard Medical School, Boston (Seidman).
FAU - Zhu, Anni
AU  - Zhu A
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China (Tang, Zhang, 
      Junjie Wang, Xu, Qian, Jijun Wang); the Psychiatry Neuroimaging Laboratory, 
      Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 
      Boston (Tang, Pasternak, Kubicki, Rathi, Zhang, Zhu, Shenton); the Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 
      (Pasternak, Kubicki, Rathi, Shenton); the Institute of Mental Health, Suzhou 
      Psychiatric Hospital, Affiliated Guangji Hospital of Soochow University, Suzhou, 
      Jiangsu, China (Junjie Wang); the Department of Psychology, Florida A&M 
      University, Tallahassee (Li); the Massachusetts Mental Health Center, Public 
      Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston (Woodberry, Keshavan, Stone, Seidman); the McGovern Institute for 
      Brain Research and the Poitras Center for Affective Disorders Research, 
      Massachusetts Institute of Technology, Cambridge (Whitfield-Gabrieli); the 
      Department of Psychiatry (Niznikiewicz, McCarley) and Research and Development 
      (Shenton), Veterans Affairs Boston Healthcare System, Brockton Division, 
      Brockton, Mass.; the Institute of Psychology and Behavioral Science, Shanghai 
      Jiao Tong University, Shanghai, China (Jijun Wang); the CAS Center for Excellence 
      in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of 
      Science, China (Jijun Wang); the Department of Psychiatry, Massachusetts General 
      Hospital, Harvard Medical School, Boston (Seidman).
FAU - Whitfield-Gabrieli, Susan
AU  - Whitfield-Gabrieli S
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China (Tang, Zhang, 
      Junjie Wang, Xu, Qian, Jijun Wang); the Psychiatry Neuroimaging Laboratory, 
      Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 
      Boston (Tang, Pasternak, Kubicki, Rathi, Zhang, Zhu, Shenton); the Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 
      (Pasternak, Kubicki, Rathi, Shenton); the Institute of Mental Health, Suzhou 
      Psychiatric Hospital, Affiliated Guangji Hospital of Soochow University, Suzhou, 
      Jiangsu, China (Junjie Wang); the Department of Psychology, Florida A&M 
      University, Tallahassee (Li); the Massachusetts Mental Health Center, Public 
      Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston (Woodberry, Keshavan, Stone, Seidman); the McGovern Institute for 
      Brain Research and the Poitras Center for Affective Disorders Research, 
      Massachusetts Institute of Technology, Cambridge (Whitfield-Gabrieli); the 
      Department of Psychiatry (Niznikiewicz, McCarley) and Research and Development 
      (Shenton), Veterans Affairs Boston Healthcare System, Brockton Division, 
      Brockton, Mass.; the Institute of Psychology and Behavioral Science, Shanghai 
      Jiao Tong University, Shanghai, China (Jijun Wang); the CAS Center for Excellence 
      in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of 
      Science, China (Jijun Wang); the Department of Psychiatry, Massachusetts General 
      Hospital, Harvard Medical School, Boston (Seidman).
FAU - Keshavan, Matcheri S
AU  - Keshavan MS
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China (Tang, Zhang, 
      Junjie Wang, Xu, Qian, Jijun Wang); the Psychiatry Neuroimaging Laboratory, 
      Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 
      Boston (Tang, Pasternak, Kubicki, Rathi, Zhang, Zhu, Shenton); the Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 
      (Pasternak, Kubicki, Rathi, Shenton); the Institute of Mental Health, Suzhou 
      Psychiatric Hospital, Affiliated Guangji Hospital of Soochow University, Suzhou, 
      Jiangsu, China (Junjie Wang); the Department of Psychology, Florida A&M 
      University, Tallahassee (Li); the Massachusetts Mental Health Center, Public 
      Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston (Woodberry, Keshavan, Stone, Seidman); the McGovern Institute for 
      Brain Research and the Poitras Center for Affective Disorders Research, 
      Massachusetts Institute of Technology, Cambridge (Whitfield-Gabrieli); the 
      Department of Psychiatry (Niznikiewicz, McCarley) and Research and Development 
      (Shenton), Veterans Affairs Boston Healthcare System, Brockton Division, 
      Brockton, Mass.; the Institute of Psychology and Behavioral Science, Shanghai 
      Jiao Tong University, Shanghai, China (Jijun Wang); the CAS Center for Excellence 
      in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of 
      Science, China (Jijun Wang); the Department of Psychiatry, Massachusetts General 
      Hospital, Harvard Medical School, Boston (Seidman).
FAU - Niznikiewicz, Margaret
AU  - Niznikiewicz M
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China (Tang, Zhang, 
      Junjie Wang, Xu, Qian, Jijun Wang); the Psychiatry Neuroimaging Laboratory, 
      Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 
      Boston (Tang, Pasternak, Kubicki, Rathi, Zhang, Zhu, Shenton); the Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 
      (Pasternak, Kubicki, Rathi, Shenton); the Institute of Mental Health, Suzhou 
      Psychiatric Hospital, Affiliated Guangji Hospital of Soochow University, Suzhou, 
      Jiangsu, China (Junjie Wang); the Department of Psychology, Florida A&M 
      University, Tallahassee (Li); the Massachusetts Mental Health Center, Public 
      Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston (Woodberry, Keshavan, Stone, Seidman); the McGovern Institute for 
      Brain Research and the Poitras Center for Affective Disorders Research, 
      Massachusetts Institute of Technology, Cambridge (Whitfield-Gabrieli); the 
      Department of Psychiatry (Niznikiewicz, McCarley) and Research and Development 
      (Shenton), Veterans Affairs Boston Healthcare System, Brockton Division, 
      Brockton, Mass.; the Institute of Psychology and Behavioral Science, Shanghai 
      Jiao Tong University, Shanghai, China (Jijun Wang); the CAS Center for Excellence 
      in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of 
      Science, China (Jijun Wang); the Department of Psychiatry, Massachusetts General 
      Hospital, Harvard Medical School, Boston (Seidman).
FAU - Stone, William S
AU  - Stone WS
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China (Tang, Zhang, 
      Junjie Wang, Xu, Qian, Jijun Wang); the Psychiatry Neuroimaging Laboratory, 
      Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 
      Boston (Tang, Pasternak, Kubicki, Rathi, Zhang, Zhu, Shenton); the Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 
      (Pasternak, Kubicki, Rathi, Shenton); the Institute of Mental Health, Suzhou 
      Psychiatric Hospital, Affiliated Guangji Hospital of Soochow University, Suzhou, 
      Jiangsu, China (Junjie Wang); the Department of Psychology, Florida A&M 
      University, Tallahassee (Li); the Massachusetts Mental Health Center, Public 
      Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston (Woodberry, Keshavan, Stone, Seidman); the McGovern Institute for 
      Brain Research and the Poitras Center for Affective Disorders Research, 
      Massachusetts Institute of Technology, Cambridge (Whitfield-Gabrieli); the 
      Department of Psychiatry (Niznikiewicz, McCarley) and Research and Development 
      (Shenton), Veterans Affairs Boston Healthcare System, Brockton Division, 
      Brockton, Mass.; the Institute of Psychology and Behavioral Science, Shanghai 
      Jiao Tong University, Shanghai, China (Jijun Wang); the CAS Center for Excellence 
      in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of 
      Science, China (Jijun Wang); the Department of Psychiatry, Massachusetts General 
      Hospital, Harvard Medical School, Boston (Seidman).
FAU - McCarley, Robert W
AU  - McCarley RW
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China (Tang, Zhang, 
      Junjie Wang, Xu, Qian, Jijun Wang); the Psychiatry Neuroimaging Laboratory, 
      Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 
      Boston (Tang, Pasternak, Kubicki, Rathi, Zhang, Zhu, Shenton); the Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 
      (Pasternak, Kubicki, Rathi, Shenton); the Institute of Mental Health, Suzhou 
      Psychiatric Hospital, Affiliated Guangji Hospital of Soochow University, Suzhou, 
      Jiangsu, China (Junjie Wang); the Department of Psychology, Florida A&M 
      University, Tallahassee (Li); the Massachusetts Mental Health Center, Public 
      Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston (Woodberry, Keshavan, Stone, Seidman); the McGovern Institute for 
      Brain Research and the Poitras Center for Affective Disorders Research, 
      Massachusetts Institute of Technology, Cambridge (Whitfield-Gabrieli); the 
      Department of Psychiatry (Niznikiewicz, McCarley) and Research and Development 
      (Shenton), Veterans Affairs Boston Healthcare System, Brockton Division, 
      Brockton, Mass.; the Institute of Psychology and Behavioral Science, Shanghai 
      Jiao Tong University, Shanghai, China (Jijun Wang); the CAS Center for Excellence 
      in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of 
      Science, China (Jijun Wang); the Department of Psychiatry, Massachusetts General 
      Hospital, Harvard Medical School, Boston (Seidman).
FAU - Shenton, Martha E
AU  - Shenton ME
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China (Tang, Zhang, 
      Junjie Wang, Xu, Qian, Jijun Wang); the Psychiatry Neuroimaging Laboratory, 
      Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 
      Boston (Tang, Pasternak, Kubicki, Rathi, Zhang, Zhu, Shenton); the Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 
      (Pasternak, Kubicki, Rathi, Shenton); the Institute of Mental Health, Suzhou 
      Psychiatric Hospital, Affiliated Guangji Hospital of Soochow University, Suzhou, 
      Jiangsu, China (Junjie Wang); the Department of Psychology, Florida A&M 
      University, Tallahassee (Li); the Massachusetts Mental Health Center, Public 
      Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston (Woodberry, Keshavan, Stone, Seidman); the McGovern Institute for 
      Brain Research and the Poitras Center for Affective Disorders Research, 
      Massachusetts Institute of Technology, Cambridge (Whitfield-Gabrieli); the 
      Department of Psychiatry (Niznikiewicz, McCarley) and Research and Development 
      (Shenton), Veterans Affairs Boston Healthcare System, Brockton Division, 
      Brockton, Mass.; the Institute of Psychology and Behavioral Science, Shanghai 
      Jiao Tong University, Shanghai, China (Jijun Wang); the CAS Center for Excellence 
      in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of 
      Science, China (Jijun Wang); the Department of Psychiatry, Massachusetts General 
      Hospital, Harvard Medical School, Boston (Seidman).
FAU - Wang, Jijun
AU  - Wang J
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China (Tang, Zhang, 
      Junjie Wang, Xu, Qian, Jijun Wang); the Psychiatry Neuroimaging Laboratory, 
      Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 
      Boston (Tang, Pasternak, Kubicki, Rathi, Zhang, Zhu, Shenton); the Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 
      (Pasternak, Kubicki, Rathi, Shenton); the Institute of Mental Health, Suzhou 
      Psychiatric Hospital, Affiliated Guangji Hospital of Soochow University, Suzhou, 
      Jiangsu, China (Junjie Wang); the Department of Psychology, Florida A&M 
      University, Tallahassee (Li); the Massachusetts Mental Health Center, Public 
      Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston (Woodberry, Keshavan, Stone, Seidman); the McGovern Institute for 
      Brain Research and the Poitras Center for Affective Disorders Research, 
      Massachusetts Institute of Technology, Cambridge (Whitfield-Gabrieli); the 
      Department of Psychiatry (Niznikiewicz, McCarley) and Research and Development 
      (Shenton), Veterans Affairs Boston Healthcare System, Brockton Division, 
      Brockton, Mass.; the Institute of Psychology and Behavioral Science, Shanghai 
      Jiao Tong University, Shanghai, China (Jijun Wang); the CAS Center for Excellence 
      in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of 
      Science, China (Jijun Wang); the Department of Psychiatry, Massachusetts General 
      Hospital, Harvard Medical School, Boston (Seidman).
FAU - Seidman, Larry J
AU  - Seidman LJ
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China (Tang, Zhang, 
      Junjie Wang, Xu, Qian, Jijun Wang); the Psychiatry Neuroimaging Laboratory, 
      Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 
      Boston (Tang, Pasternak, Kubicki, Rathi, Zhang, Zhu, Shenton); the Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston 
      (Pasternak, Kubicki, Rathi, Shenton); the Institute of Mental Health, Suzhou 
      Psychiatric Hospital, Affiliated Guangji Hospital of Soochow University, Suzhou, 
      Jiangsu, China (Junjie Wang); the Department of Psychology, Florida A&M 
      University, Tallahassee (Li); the Massachusetts Mental Health Center, Public 
      Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston (Woodberry, Keshavan, Stone, Seidman); the McGovern Institute for 
      Brain Research and the Poitras Center for Affective Disorders Research, 
      Massachusetts Institute of Technology, Cambridge (Whitfield-Gabrieli); the 
      Department of Psychiatry (Niznikiewicz, McCarley) and Research and Development 
      (Shenton), Veterans Affairs Boston Healthcare System, Brockton Division, 
      Brockton, Mass.; the Institute of Psychology and Behavioral Science, Shanghai 
      Jiao Tong University, Shanghai, China (Jijun Wang); the CAS Center for Excellence 
      in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of 
      Science, China (Jijun Wang); the Department of Psychiatry, Massachusetts General 
      Hospital, Harvard Medical School, Boston (Seidman).
LA  - eng
GR  - I01 CX000157/CX/CSRD VA/United States
GR  - R01 MH102377/MH/NIMH NIH HHS/United States
GR  - I01 CX000176/CX/CSRD VA/United States
GR  - R01 MH101052/MH/NIMH NIH HHS/United States
GR  - R01 MH074794/MH/NIMH NIH HHS/United States
GR  - R01 MH108574/MH/NIMH NIH HHS/United States
GR  - K23 MH102358/MH/NIMH NIH HHS/United States
GR  - R01 MH111448/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190624
PL  - United States
TA  - Am J Psychiatry
JT  - The American journal of psychiatry
JID - 0370512
RN  - 059QF0KO0R (Water)
SB  - IM
CIN - Am J Psychiatry. 2019 Oct 1;176(10):777-779. PMID: 31569992
MH  - Brain/*diagnostic imaging/pathology
MH  - Case-Control Studies
MH  - Diffusion Magnetic Resonance Imaging
MH  - Extracellular Space/metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Neuroimaging
MH  - Psychotic Disorders/*diagnostic imaging/pathology
MH  - Risk Factors
MH  - Water
MH  - White Matter/*diagnostic imaging/pathology
MH  - Young Adult
PMC - PMC7142275
MID - NIHMS1573563
OTO - NOTNLM
OT  - Clinical High-Risk
OT  - Diffusion Tensor Imaging
OT  - Free Water
OT  - Neurodevelopment
OT  - Psychosis
OT  - White Matter
EDAT- 2019/06/25 06:00
MHDA- 2020/03/21 06:00
PMCR- 2020/10/01
CRDT- 2019/06/25 06:00
PHST- 2019/06/25 06:00 [pubmed]
PHST- 2020/03/21 06:00 [medline]
PHST- 2019/06/25 06:00 [entrez]
PHST- 2020/10/01 00:00 [pmc-release]
AID - 10.1176/appi.ajp.2019.18091044 [doi]
PST - ppublish
SO  - Am J Psychiatry. 2019 Oct 1;176(10):820-828. doi: 10.1176/appi.ajp.2019.18091044. 
      Epub 2019 Jun 24.