PMID- 31231487
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2008-3866 (Print)
IS  - 2008-3874 (Electronic)
IS  - 2008-3866 (Linking)
VI  - 22
IP  - 6
DP  - 2019 Jun
TI  - Human leukocyte antigen (HLA)-Cw0303, HLA-Cw04, and HLA-Cw07 polymorphisms are 
      associated with susceptibility of rheumatoid arthritis in Chinese Han patients 
      from Southern China.
PG  - 610-616
LID - 10.22038/ijbms.2019.33557.8007 [doi]
AB  - OBJECTIVES: This study aimed to investigate the association between human 
      leukocyte antigen Cw (HLA-Cw) polymorphisms and rheumatoid arthritis (RA) in 
      Chinese Han patients in the Jiangsu area (Southern China). MATERIALS AND METHODS: 
      Polymerase chain reaction-sequence specific primers were used to detect 
      HLA-Cw01-08 of 201 RA patients and 211 healthy individuals from Zhongda Hospital 
      (China). The allele frequency distribution of HLA-Cw and genotypic differences 
      between the two groups were analyzed. RESULTS: The frequency of HLA-Cw0303 in 
      patients with RA was significantly higher than that in controls, while the 
      frequency of HLA-Cw04 was lower than that in controls (P<0.05). The gene 
      frequency of HLA-Cw07 in anti-cyclic citrullinated peptide (anti-CCP)-negative 
      patients was higher than that in controls (P=0.044). The frequency of HLA-Cw04 
      was decreased in the short duration subgroup and increased in the long duration 
      subgroup (P<0.05). Compared to controls, the frequency of HLA-Cw0303 in patients 
      with RA and morning stiffness was increased (P=0.004), while the frequency of 
      HLA-Cw04 was decreased ( 0.005). CONCLUSION: These results suggest that 
      HLA-Cw0303 is a susceptibility gene for RA in Chinese Han patients in the Jiangsu 
      area of southern China. The HLA-Cw04 gene may be a protective factor against RA, 
      while HLA-Cw07 might play a protective role in the production of anti-CCP in the 
      long-term course in patients with RA.
FAU - Yang, Chuankun
AU  - Yang C
AD  - Department of Immunology Laboratory, Zhongda Hospital, School of medicine, 
      Southeast University, Nanjing, Jiangsu, 210009, China.
FAU - Wang, Chunling
AU  - Wang C
AD  - Department of Immunology Laboratory, Zhongda Hospital, School of medicine, 
      Southeast University, Nanjing, Jiangsu, 210009, China.
FAU - Shi, Yan
AU  - Shi Y
AD  - Department of Immunology Laboratory, Zhongda Hospital, School of medicine, 
      Southeast University, Nanjing, Jiangsu, 210009, China.
FAU - Li, Li
AU  - Li L
AD  - Department of Immunology Laboratory, Zhongda Hospital, School of medicine, 
      Southeast University, Nanjing, Jiangsu, 210009, China.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Basic Med Sci
JT  - Iranian journal of basic medical sciences
JID - 101517966
PMC - PMC6570748
OTO - NOTNLM
OT  - Anti-citrullinated protein - antibodies
OT  - Arthritis rheumatoid
OT  - Gene frequency
OT  - HLA antigens
OT  - Polymorphism
OT  - Single nucleotide
COIS- All authors declared that they have no conflict of interest.
EDAT- 2019/06/25 06:00
MHDA- 2019/06/25 06:01
PMCR- 2019/06/01
CRDT- 2019/06/25 06:00
PHST- 2019/06/25 06:00 [entrez]
PHST- 2019/06/25 06:00 [pubmed]
PHST- 2019/06/25 06:01 [medline]
PHST- 2019/06/01 00:00 [pmc-release]
AID - 10.22038/ijbms.2019.33557.8007 [doi]
PST - ppublish
SO  - Iran J Basic Med Sci. 2019 Jun;22(6):610-616. doi: 
      10.22038/ijbms.2019.33557.8007.