PMID- 31231669
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2306-9759 (Print)
IS  - 2313-0792 (Electronic)
IS  - 2306-9759 (Linking)
VI  - 6
DP  - 2019
TI  - Lineage switch from T-cell lymphoblastic leukemia/lymphoma to acute myeloid 
      leukemia and back to T-cell lymphoblastic leukemia/lymphoma in a patient 
      diagnosed during pregnancy.
PG  - 12
LID - 10.21037/sci.2019.05.02 [doi]
LID - 12
AB  - Although relapse of acute leukemia is common, a change of immunophenotype at 
      relapse only occurs rarely. Some of these cases have been labeled "lineage 
      switch". In most cases, B-cell lymphoblastic leukemia/lymphoma (B-ALL) relapses 
      as acute myeloid leukemia (AML). We report a rare case of T-cell acute 
      lymphoblastic leukemia/lymphoma (T-ALL) relapsing as AML and then returning as 
      T-ALL again in a patient who began her therapy during the third trimester of 
      pregnancy. The patient retained the same cytogenetic and next generation 
      molecular findings in both leukemias. This case provides further evidence of the 
      plasticity of the leukemic stem cell.
FAU - Aujla, Amandeep
AU  - Aujla A
AD  - Department of Medicine, New York Medical College and Westchester Medical Center, 
      Valhalla, NY, USA.
AD  - Department of Hematology & Oncology, New York Medical College and Westchester 
      Medical Center, Valhalla, NY, USA.
FAU - Hanmantgad, Madhura
AU  - Hanmantgad M
AD  - Department of Medicine, New York Medical College and Westchester Medical Center, 
      Valhalla, NY, USA.
AD  - Department of Hematology & Oncology, New York Medical College and Westchester 
      Medical Center, Valhalla, NY, USA.
FAU - Islam, Humayun
AU  - Islam H
AD  - Department of Pathology, New York Medical College and Westchester Medical Center, 
      Valhalla, NY, USA.
FAU - Shakil, Fouzia
AU  - Shakil F
AD  - Department of Pathology, New York Medical College and Westchester Medical Center, 
      Valhalla, NY, USA.
FAU - Liu, Delong
AU  - Liu D
AD  - Department of Medicine, New York Medical College and Westchester Medical Center, 
      Valhalla, NY, USA.
AD  - Department of Hematology & Oncology, New York Medical College and Westchester 
      Medical Center, Valhalla, NY, USA.
FAU - Seiter, Karen
AU  - Seiter K
AD  - Department of Medicine, New York Medical College and Westchester Medical Center, 
      Valhalla, NY, USA.
AD  - Department of Hematology & Oncology, New York Medical College and Westchester 
      Medical Center, Valhalla, NY, USA.
LA  - eng
PT  - Case Reports
DEP - 20190524
PL  - China
TA  - Stem Cell Investig
JT  - Stem cell investigation
JID - 101672113
PMC - PMC6556683
OTO - NOTNLM
OT  - Acute lymphoblastic leukemia (ALL)
OT  - acute myeloid leukemia (AML)
OT  - lineage switch
OT  - pregnancy
OT  - stem cell plasticity
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2019/06/25 06:00
MHDA- 2019/06/25 06:01
PMCR- 2019/05/24
CRDT- 2019/06/25 06:00
PHST- 2019/04/02 00:00 [received]
PHST- 2019/05/15 00:00 [accepted]
PHST- 2019/06/25 06:00 [entrez]
PHST- 2019/06/25 06:00 [pubmed]
PHST- 2019/06/25 06:01 [medline]
PHST- 2019/05/24 00:00 [pmc-release]
AID - sci-06-2019.05.02 [pii]
AID - 10.21037/sci.2019.05.02 [doi]
PST - epublish
SO  - Stem Cell Investig. 2019 May 24;6:12. doi: 10.21037/sci.2019.05.02. eCollection 
      2019.