PMID- 31232107
OWN - NLM
STAT- MEDLINE
DCOM- 20200708
LR  - 20200708
IS  - 1477-2213 (Electronic)
IS  - 1028-6020 (Linking)
VI  - 22
IP  - 8
DP  - 2020 Aug
TI  - Ginsenoside Re enhances the survival of H9c2 cardiac muscle cells through 
      regulation of autophagy.
PG  - 774-787
LID - 10.1080/10286020.2019.1632834 [doi]
AB  - We examined the effect of ginsenoside Re (G-Re) on autophagy in H9c2 
      cardiomyocytes cultured in glucose deprivation (GD). Levels of the membrane-bound 
      autophagy-related microtubule-associated protein 1A/1B-light chain 3 (LC3) B-2 
      were measured via immunoblotting and immunofluorescence was conducted to assess 
      autophagosome formation. GD H9c2 cells were treated with 100 mumol/l G-Re. Cell 
      viability was determined in culture medium. Phosphorylated 5' AMP-activated 
      protein kinase (AMPK)-alpha and mammalian target of rapamycin (mTOR) levels were 
      measured to explore the mechanisms underlying the effects of G-Re on autophagy in 
      GD cells. G-Re treatment inhibited autophagosome formation and may be beneficial 
      to GD cardiomyocytes.
FAU - Zhang, Zi-Long
AU  - Zhang ZL
AD  - Department of Cardiology, Emergency General Hospital, Beijing 100028, China.
FAU - Liu, Mei-Lin
AU  - Liu ML
AD  - Department of Geriatric, Peking University First Hospital, Beijing 100034, China.
FAU - Huang, Ying-Shuo
AU  - Huang YS
AD  - Department of Research Ward, Beijing Friendship Hospital, Capital Medical 
      University, Beijing 100050, China.
FAU - Liang, Wen-Yi
AU  - Liang WY
AD  - Department of Geriatric, Peking University First Hospital, Beijing 100034, China.
FAU - Zhang, Miao-Miao
AU  - Zhang MM
AD  - Department of Cardiology, Emergency General Hospital, Beijing 100028, China.
FAU - Fan, Yu-Dong
AU  - Fan YD
AD  - Department of Cardiology, Emergency General Hospital, Beijing 100028, China.
FAU - Ma, Ming-Feng
AU  - Ma MF
AD  - Department of Cardiology, Fenyang Hospital of Shanxi Province, Fenyang 032200, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20190622
PL  - England
TA  - J Asian Nat Prod Res
JT  - Journal of Asian natural products research
JID - 100888334
RN  - 0 (Ginsenosides)
RN  - 46F3R0BL3I (ginsenoside Re)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
SB  - IM
MH  - AMP-Activated Protein Kinases
MH  - *Autophagy
MH  - Cell Survival
MH  - *Ginsenosides
MH  - Molecular Structure
MH  - Myocytes, Cardiac
OTO - NOTNLM
OT  - AMPKalpha
OT  - Ginsenoside Re
OT  - H9c2 cells
OT  - autophagy
OT  - starvation
EDAT- 2019/06/25 06:00
MHDA- 2020/07/09 06:00
CRDT- 2019/06/25 06:00
PHST- 2019/06/25 06:00 [pubmed]
PHST- 2020/07/09 06:00 [medline]
PHST- 2019/06/25 06:00 [entrez]
AID - 10.1080/10286020.2019.1632834 [doi]
PST - ppublish
SO  - J Asian Nat Prod Res. 2020 Aug;22(8):774-787. doi: 10.1080/10286020.2019.1632834. 
      Epub 2019 Jun 22.