PMID- 31232610
OWN - NLM
STAT- MEDLINE
DCOM- 20190819
LR  - 20190819
IS  - 1751-2441 (Electronic)
IS  - 1751-2433 (Linking)
VI  - 12
IP  - 8
DP  - 2019 Aug
TI  - Clinical pharmacology of old age.
PG  - 749-755
LID - 10.1080/17512433.2019.1632188 [doi]
AB  - Introduction: With the majority of elderly persons consuming multiple drugs, 
      inappropriate drug use is a major issue in geriatric medicine. Areas covered: We 
      reviewed PubMed, Embase, and Cochrane from inception to 1 May 2019 for 
      potentially inappropriate use of medications, polypharmacy, and age-dependent 
      changes in pharmacokinetics and pharmacodynamics. We selected to highlight new 
      aspects that have emerged in recent years: appropriate monitoring of drug 
      adherence and the introduction of Big Data analysis in advancing geriatric 
      pharmacology. Expert opinion: There are major gaps in the pharmacological 
      treatment of the elderly. Most drugs were designed and tested in adults, with no 
      pharmacokinetic and pharmacodynamic data on changes in old age. This void must be 
      corrected through systematic and well-designed research programs. Potentially 
      inappropriate use of medications (PIM) in the elderly is a serious issue in 
      advanced age. Analysis of PIM shows relatively low predictive value in real life 
      medicine. Most physicians continue to prescribe to the elderly medicines which 
      should not be given at all, or not combined. Polypharmacy is a complex issue in 
      old age, and in many cases treating physicians are not conducting critical 
      assessment of the need for numerous medications.
FAU - Koren, Gideon
AU  - Koren G
AD  - a Maccabi-Kahn Institute of Research and Innovation , Tel Aviv , Israel.
AD  - b Ariel University , Ariel , Israel.
AD  - c Technion Institute of Technology , Haifa , Israel.
FAU - Nordon, Galia
AU  - Nordon G
AD  - c Technion Institute of Technology , Haifa , Israel.
FAU - Radinsky, Kira
AU  - Radinsky K
AD  - c Technion Institute of Technology , Haifa , Israel.
FAU - Shalev, Varda
AU  - Shalev V
AD  - a Maccabi-Kahn Institute of Research and Innovation , Tel Aviv , Israel.
AD  - d Tel Aviv University , Tel Aviv , Israel.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190624
PL  - England
TA  - Expert Rev Clin Pharmacol
JT  - Expert review of clinical pharmacology
JID - 101278296
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Humans
MH  - Inappropriate Prescribing/*statistics & numerical data
MH  - Medication Adherence
MH  - Polypharmacy
MH  - Potentially Inappropriate Medication List/*statistics & numerical data
MH  - Practice Patterns, Physicians'/*standards
MH  - Research Design
MH  - Risk Factors
OTO - NOTNLM
OT  - Old age
OT  - adherence
OT  - artificial intelligence
OT  - big data analysis
OT  - drugs
OT  - machine learning
OT  - pharmacodynamics
OT  - pharmacokinetics
OT  - polypharmacy
OT  - potentially inappropriate medications
EDAT- 2019/06/25 06:00
MHDA- 2019/08/20 06:00
CRDT- 2019/06/25 06:00
PHST- 2019/06/25 06:00 [pubmed]
PHST- 2019/08/20 06:00 [medline]
PHST- 2019/06/25 06:00 [entrez]
AID - 10.1080/17512433.2019.1632188 [doi]
PST - ppublish
SO  - Expert Rev Clin Pharmacol. 2019 Aug;12(8):749-755. doi: 
      10.1080/17512433.2019.1632188. Epub 2019 Jun 24.