PMID- 31233225
OWN - NLM
STAT- MEDLINE
DCOM- 20200324
LR  - 20231213
IS  - 1600-0560 (Electronic)
IS  - 0303-6987 (Linking)
VI  - 46
IP  - 12
DP  - 2019 Dec
TI  - BRCA1-associated protein (BAP1)-inactivated melanocytic tumors.
PG  - 965-972
LID - 10.1111/cup.13530 [doi]
AB  - Although discussed using variable terminology, cutaneous BRCA1-associated protein 
      (BAP1)-inactivated melanocytic tumor (BIMT) has been considered a discrete 
      diagnostic entity since 2011. Here, we review the initial genomic studies that 
      identified these distinct melanocytic tumors and the clinical and 
      histopathological features that define these tumors. These epithelioid, 
      predominantly dermal, and melanocytic tumors present as erythematous nodules and 
      histopathologically have features that may overlap with Spitz nevi and nevoid 
      melanoma. There is no sex predilection, and cutaneous BIMTs can appear at any 
      age; however, in most familial (germline mutant) cases patients have multiple 
      cutaneous tumors with a first diagnosis in the second or third decade of life; 
      ocular melanoma and other tumors are increasingly identified in these kindreds 
      with germline BAP1 mutation. These tumors have been described with a myriad of 
      terms including: Wiesner nevus, nevoid melanoma-like melanocytic proliferation 
      (NEMMP), BAP1 mutant Spitz nevus, BAP1 mutant nevoid melanoma, cutaneous BAPoma, 
      and most recently cutaneous BIMT.
CI  - (c) 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Zhang, Arianna J
AU  - Zhang AJ
AUID- ORCID: 0000-0002-4569-0557
AD  - Pathology Service, Massachusetts General Hospital, Boston, Massachusetts.
FAU - Rush, Patrick S
AU  - Rush PS
AD  - Dominion Pathology Associates, Roanoke, Virginia.
FAU - Tsao, Hensin
AU  - Tsao H
AD  - School of Medicine, Harvard University, Boston, Massachusetts.
AD  - Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts.
FAU - Duncan, Lyn M
AU  - Duncan LM
AUID- ORCID: 0000-0003-3732-8256
AD  - Pathology Service, Massachusetts General Hospital, Boston, Massachusetts.
AD  - School of Medicine, Harvard University, Boston, Massachusetts.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190711
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
RN  - 0 (BAP1 protein, human)
RN  - 0 (BRCA1 Protein)
RN  - 0 (BRCA1 protein, human)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 3.4.19.12 (Ubiquitin Thiolesterase)
SB  - IM
MH  - BRCA1 Protein/*metabolism
MH  - Cell Proliferation
MH  - Eye Neoplasms/*genetics/pathology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Germ-Line Mutation/genetics
MH  - Humans
MH  - Male
MH  - Melanocytes/*pathology
MH  - Melanoma/*genetics/pathology
MH  - Nevus, Epithelioid and Spindle Cell/*genetics/pathology
MH  - Skin/pathology
MH  - Skin Neoplasms/*genetics/pathology
MH  - Tumor Suppressor Proteins/*metabolism
MH  - Ubiquitin Thiolesterase/*metabolism
MH  - Melanoma, Cutaneous Malignant
OTO - NOTNLM
OT  - BAP1-inactivated naevus/melanocytoma
OT  - BAP1
OT  - BIMT
OT  - Spitz
EDAT- 2019/06/25 06:00
MHDA- 2020/03/25 06:00
CRDT- 2019/06/25 06:00
PHST- 2019/02/25 00:00 [received]
PHST- 2019/06/18 00:00 [revised]
PHST- 2019/06/20 00:00 [accepted]
PHST- 2019/06/25 06:00 [pubmed]
PHST- 2020/03/25 06:00 [medline]
PHST- 2019/06/25 06:00 [entrez]
AID - 10.1111/cup.13530 [doi]
PST - ppublish
SO  - J Cutan Pathol. 2019 Dec;46(12):965-972. doi: 10.1111/cup.13530. Epub 2019 Jul 
      11.