PMID- 31233732
OWN - NLM
STAT- MEDLINE
DCOM- 20200225
LR  - 20200225
IS  - 1096-0945 (Electronic)
IS  - 0014-4800 (Linking)
VI  - 110
DP  - 2019 Oct
TI  - SPARC correlates with unfavorable outcome and promotes tumor growth in lung 
      squamous cell carcinoma.
PG  - 104276
LID - S0014-4800(19)30417-4 [pii]
LID - 10.1016/j.yexmp.2019.104276 [doi]
AB  - Secreted protein acidic and rich in cysteine (SPARC) plays a crucial role in the 
      malignant progression of a number of human cancers. However, the roles of SPARC 
      in lung squamous cell carcinoma (LSCC) remain elusive. In this present study, we 
      first detected SPARC expression and investigated the relationship between SPARC 
      expression and the clinicopathological attributes of LSCC patients. Then we 
      constructed SPARC-overexpression model in LSCC cell line to explore the 
      characteristics of SPARC in LSCC development both in vitro and in vivo. The data 
      demonstrated a remarkably higher level of SPARC in LSCC tissues than in 
      corresponding non-cancerous tissues and elevated SPARC expression was 
      significantly correlated with poor outcome in LSCC patients. Moreover, a serial 
      of phenotypic experiments indicated that SPARC overexpression substantially 
      facilitated the growth and inhibited the apoptosis in LSCC cells and xenografts. 
      Taken together, our results suggest that SPARC is a novel prognostic marker for 
      LSCC prognosis and SPARC significantly promotes LSCC tumorigenesis. Targeting 
      SPARC may provide a novel therapeutic strategy for LSCC management.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Xu, Juqing
AU  - Xu J
AD  - Department of Hematology and Oncology, Department of Geriatric Lung Cancer 
      Laboratory, Geriatric Hospital of Nanjing Medical University, Jiangsu Province 
      Geriatric Hospital, Nanjing, Jiangsu, China.
FAU - Yang, Shu
AU  - Yang S
AD  - Department of Hematology and Oncology, Department of Geriatric Lung Cancer 
      Laboratory, Geriatric Hospital of Nanjing Medical University, Jiangsu Province 
      Geriatric Hospital, Nanjing, Jiangsu, China.
FAU - Gu, Xuefeng
AU  - Gu X
AD  - Department of Infectious Diseases, The Second Hospital of Nanjing, 1-1 Zhongfu 
      Street, Nanjing, Jiangsu, China.
FAU - Shen, Hongyu
AU  - Shen H
AD  - Department of Hematology and Oncology, Department of Geriatric Lung Cancer 
      Laboratory, Geriatric Hospital of Nanjing Medical University, Jiangsu Province 
      Geriatric Hospital, Nanjing, Jiangsu, China.
FAU - Wang, Lin
AU  - Wang L
AD  - Department of Hematology and Oncology, Department of Geriatric Lung Cancer 
      Laboratory, Geriatric Hospital of Nanjing Medical University, Jiangsu Province 
      Geriatric Hospital, Nanjing, Jiangsu, China.
FAU - Xu, Wei
AU  - Xu W
AD  - Department of Hematology and Oncology, Department of Geriatric Lung Cancer 
      Laboratory, Geriatric Hospital of Nanjing Medical University, Jiangsu Province 
      Geriatric Hospital, Nanjing, Jiangsu, China.
FAU - Fang, Leping
AU  - Fang L
AD  - Department of Hematology and Oncology, Department of Geriatric Lung Cancer 
      Laboratory, Geriatric Hospital of Nanjing Medical University, Jiangsu Province 
      Geriatric Hospital, Nanjing, Jiangsu, China.
FAU - Mao, Yuan
AU  - Mao Y
AD  - Department of Hematology and Oncology, Department of Geriatric Lung Cancer 
      Laboratory, Geriatric Hospital of Nanjing Medical University, Jiangsu Province 
      Geriatric Hospital, Nanjing, Jiangsu, China.
FAU - Xu, Li
AU  - Xu L
AD  - Department of Pathology, Jiangsu Cancer Hospital, Affiliated Cancer Hospital of 
      Nanjing Medical University, Nanjing, Jiangsu, China.
FAU - Chen, Yan
AU  - Chen Y
AD  - Department of Pathology, Jiangsu Cancer Hospital, Affiliated Cancer Hospital of 
      Nanjing Medical University, Nanjing, Jiangsu, China.
FAU - Fan, Weifei
AU  - Fan W
AD  - Department of Hematology and Oncology, Department of Geriatric Lung Cancer 
      Laboratory, Geriatric Hospital of Nanjing Medical University, Jiangsu Province 
      Geriatric Hospital, Nanjing, Jiangsu, China. Electronic address: 
      fwfei1974@njmu.edu.cn.
FAU - Wang, Jun
AU  - Wang J
AD  - Department of Hematology and Oncology, Department of Geriatric Lung Cancer 
      Laboratory, Geriatric Hospital of Nanjing Medical University, Jiangsu Province 
      Geriatric Hospital, Nanjing, Jiangsu, China. Electronic address: 
      wangjun1959@njmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190621
PL  - Netherlands
TA  - Exp Mol Pathol
JT  - Experimental and molecular pathology
JID - 0370711
RN  - 0 (Osteonectin)
RN  - 0 (SPARC protein, human)
SB  - IM
MH  - Animals
MH  - Carcinogenesis/*genetics/metabolism
MH  - Carcinoma, Squamous Cell/*genetics/metabolism/pathology
MH  - Cell Line, Tumor
MH  - Cell Proliferation/genetics
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lung Neoplasms/*genetics/metabolism/pathology
MH  - Male
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - Middle Aged
MH  - Osteonectin/*genetics/metabolism
MH  - Prognosis
MH  - Transplantation, Heterologous
MH  - Tumor Burden/genetics
OTO - NOTNLM
OT  - Biomarker
OT  - LSCC
OT  - Prognosis
OT  - SPARC
OT  - Tumorigenesis
EDAT- 2019/06/25 06:00
MHDA- 2020/02/26 06:00
CRDT- 2019/06/25 06:00
PHST- 2019/06/02 00:00 [received]
PHST- 2019/06/17 00:00 [revised]
PHST- 2019/06/20 00:00 [accepted]
PHST- 2019/06/25 06:00 [pubmed]
PHST- 2020/02/26 06:00 [medline]
PHST- 2019/06/25 06:00 [entrez]
AID - S0014-4800(19)30417-4 [pii]
AID - 10.1016/j.yexmp.2019.104276 [doi]
PST - ppublish
SO  - Exp Mol Pathol. 2019 Oct;110:104276. doi: 10.1016/j.yexmp.2019.104276. Epub 2019 
      Jun 21.