PMID- 31233761
OWN - NLM
STAT- MEDLINE
DCOM- 20190924
LR  - 20190925
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 232
DP  - 2019 Sep 1
TI  - Sleep deprivation worsened oral ulcers and delayed healing process in an 
      experimental rat model.
PG  - 116594
LID - S0024-3205(19)30520-X [pii]
LID - 10.1016/j.lfs.2019.116594 [doi]
AB  - AIMS: Sleep deficiency has been reported to be associated with some oral health 
      problems. Oral ulcers are very common lesions of the oral mucosa, which severely 
      impact patients' quality of life. However, the association between sleep 
      deficiency and the oral ulcer remains unknown. The present study aims to explore 
      the effects of sleep deficiency on oral ulcers. MAIN METHODS: Rats were divided 
      into normal control group (n = 30) and oral ulcer group (OU group, n = 50). Model 
      rats with phenol-induced oral ulcers were deprived of sleep for 72 h by using the 
      modified multiple platform technique. KEY FINDINGS: Sleep deprivation worsened 
      oral ulcers and delayed healing process in rats. In addition, sleep deprivation 
      increased the gamma-aminobutyric acid (GABA, P < 0.01) and 5-hydroxytryptamine (5-HT, 
      P < 0.05) levels in serum and brain, the corticotrophin (ACTH, P < 0.05), 
      corticosterone (CORT, P < 0.01), immunoglobulin (Ig)M (P < 0.01), tumor necrosis 
      factor-alpha (TNF-alpha) (P < 0.01), interleukin (IL)-1beta (P < 0.01), IL-6 (P < 0.01), 
      IL-8 (P < 0.01), monocyte chemoattractant protein-1 (MCP-1) (P < 0.01), and 
      8-hydroxy-deoxyguanosine (8-OHdG, P < 0.01) levels in serum. Sleep deprivation 
      also up-regulated malonaldehyde (MDA) (P < 0.05), TNF-alpha (P < 0.05), and IL-1beta 
      (P < 0.01) levels in oral mucosa tissue and delayed superoxide dismutase (SOD, 
      P < 0.05) activity recovery. SIGNIFICANCE: These data suggest that sleep 
      deprivation impaired the oral ulcer healing in rat oral mucosa, and the 
      mechanisms of this effect are probably related to neuro-immuno-endocrine system 
      and oxidative stress.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Chen, Pan
AU  - Chen P
AD  - Guangdong Engineering and Technology Research Center for Quality and Efficacy 
      Re-evaluation of Post-marketed TCM, Guangdong Key Laboratory of Plant Resources, 
      School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
FAU - Yao, Hongliang
AU  - Yao H
AD  - Guangdong Engineering and Technology Research Center for Quality and Efficacy 
      Re-evaluation of Post-marketed TCM, Guangdong Key Laboratory of Plant Resources, 
      School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
FAU - Su, Weiwei
AU  - Su W
AD  - Guangdong Engineering and Technology Research Center for Quality and Efficacy 
      Re-evaluation of Post-marketed TCM, Guangdong Key Laboratory of Plant Resources, 
      School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
FAU - He, Yudong
AU  - He Y
AD  - Guangdong Engineering and Technology Research Center for Quality and Efficacy 
      Re-evaluation of Post-marketed TCM, Guangdong Key Laboratory of Plant Resources, 
      School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
FAU - Cheng, Keling
AU  - Cheng K
AD  - Guangdong Engineering and Technology Research Center for Quality and Efficacy 
      Re-evaluation of Post-marketed TCM, Guangdong Key Laboratory of Plant Resources, 
      School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
FAU - Wang, Yonggang
AU  - Wang Y
AD  - Guangdong Engineering and Technology Research Center for Quality and Efficacy 
      Re-evaluation of Post-marketed TCM, Guangdong Key Laboratory of Plant Resources, 
      School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
FAU - Peng, Wei
AU  - Peng W
AD  - Guangdong Engineering and Technology Research Center for Quality and Efficacy 
      Re-evaluation of Post-marketed TCM, Guangdong Key Laboratory of Plant Resources, 
      School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
FAU - Li, Peibo
AU  - Li P
AD  - Guangdong Engineering and Technology Research Center for Quality and Efficacy 
      Re-evaluation of Post-marketed TCM, Guangdong Key Laboratory of Plant Resources, 
      School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. 
      Electronic address: lipeibo@mail.sysu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20190621
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animals
MH  - Gastric Mucosa/metabolism
MH  - Interleukin-1beta/metabolism
MH  - Interleukin-6/metabolism
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Models, Animal
MH  - Mouth Mucosa/metabolism
MH  - Oral Ulcer/*metabolism/physiopathology
MH  - Oxidative Stress/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sleep Deprivation/metabolism/*physiopathology
MH  - Superoxide Dismutase/metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Wound Healing/*physiology
OTO - NOTNLM
OT  - Cytokines
OT  - Neuro-immuno-endocrine system
OT  - Oral ulcer
OT  - Oxidative stress
OT  - Sleep deprivation
EDAT- 2019/06/25 06:00
MHDA- 2019/09/26 06:00
CRDT- 2019/06/25 06:00
PHST- 2019/04/16 00:00 [received]
PHST- 2019/06/06 00:00 [revised]
PHST- 2019/06/20 00:00 [accepted]
PHST- 2019/06/25 06:00 [pubmed]
PHST- 2019/09/26 06:00 [medline]
PHST- 2019/06/25 06:00 [entrez]
AID - S0024-3205(19)30520-X [pii]
AID - 10.1016/j.lfs.2019.116594 [doi]
PST - ppublish
SO  - Life Sci. 2019 Sep 1;232:116594. doi: 10.1016/j.lfs.2019.116594. Epub 2019 Jun 
      21.