PMID- 31234782
OWN - NLM
STAT- MEDLINE
DCOM- 20200113
LR  - 20200309
IS  - 1471-2342 (Electronic)
IS  - 1471-2342 (Linking)
VI  - 19
IP  - 1
DP  - 2019 Jun 24
TI  - Ethiodized poppyseed oil versus ioversol for image quality and adverse events in 
      hysterosalpingography: a prospective cohort study.
PG  - 50
LID - 10.1186/s12880-019-0346-0 [doi]
LID - 50
AB  - BACKGROUND: This study aimed to investigate the image quality and adverse events 
      (AEs) of ethiodized poppyseed oil (EPO) compared with ioversol as contrast agents 
      in hysterosalpingography (HSG). METHODS: Two hundred twenty-eight patients 
      underwent HSG were consecutively recruited in this prospective cohort study, and 
      were accordingly divided into EPO group (N = 165) and ioversol group (N = 63). 
      The quality of image was assessed according to the European Guidelines on quality 
      criteria for diagnostic radiographic images. AEs during, within 2 h and at 
      1-month post-HSG were recorded. RESULTS: EPO displayed elevated image quality 
      compared with ioversol including the total image quality score (P < 0.001), the 
      cervical canal display score (P < 0.001), shape and outline of uterus score 
      (P < 0.01), cervical mucosa or folds score (P < 0.001), oviduct isthmus score 
      (P < 0.001), ampulla and fimbriae of oviduct score (P < 0.001) and celiac diffuse 
      image score (P < 0.001). Multivariate linear regression displayed that EPO 
      (P < 0.001) was an independent predictive factor for increased total image 
      quality score. AEs were similar between EPO group and ioversol group during and 
      within 2 h post-HSG (all P > 0.05). However, at 1-month post-HSG, the number of 
      patients had unchanged and faded menstrual blood color decreased but the 
      proportion of patients with deepened menstrual color increased in EPO group 
      compared with ioversol group (P = 0.007). In addition, the number of patients had 
      iodine residue in uterine cavity was elevated in EPO group compared with ioversol 
      group (P < 0.001). CONCLUSION: EPO is more efficient in image quality and equally 
      tolerant compared to ioversol as contrast agents in HSG.
FAU - Tan, Yiqing
AU  - Tan Y
AUID- ORCID: 0000-0001-8689-3900
AD  - Department of Radiology, Wuhan Third Hospital, Tongren Hospital of Wuhan 
      University, 241 Liuyang Road, Wuhan, 430063, Hubei, China. tanyiqing72@163.com.
FAU - Zheng, Shilin
AU  - Zheng S
AD  - Department of Radiology, Wuhan Third Hospital, Tongren Hospital of Wuhan 
      University, 241 Liuyang Road, Wuhan, 430063, Hubei, China.
FAU - Lei, Wenfeng
AU  - Lei W
AD  - Department of Radiology, Wuhan Third Hospital, Tongren Hospital of Wuhan 
      University, 241 Liuyang Road, Wuhan, 430063, Hubei, China.
FAU - Wang, Fuhua
AU  - Wang F
AD  - Department of Radiology, Wuhan Third Hospital, Tongren Hospital of Wuhan 
      University, 241 Liuyang Road, Wuhan, 430063, Hubei, China.
FAU - Jiang, Shengpan
AU  - Jiang S
AD  - Department of Radiology, Wuhan Third Hospital, Tongren Hospital of Wuhan 
      University, 241 Liuyang Road, Wuhan, 430063, Hubei, China.
FAU - Zeng, Ting
AU  - Zeng T
AD  - Department of Radiology, Wuhan Third Hospital, Tongren Hospital of Wuhan 
      University, 241 Liuyang Road, Wuhan, 430063, Hubei, China.
FAU - Zhou, Bei
AU  - Zhou B
AD  - Department of Radiology, Wuhan Third Hospital, Tongren Hospital of Wuhan 
      University, 241 Liuyang Road, Wuhan, 430063, Hubei, China.
FAU - Hong, Fan
AU  - Hong F
AD  - Department of Radiology, Wuhan Third Hospital, Tongren Hospital of Wuhan 
      University, 241 Liuyang Road, Wuhan, 430063, Hubei, China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190624
PL  - England
TA  - BMC Med Imaging
JT  - BMC medical imaging
JID - 100968553
RN  - 0 (Contrast Media)
RN  - 0 (Triiodobenzoic Acids)
RN  - 8008-53-5 (Ethiodized Oil)
RN  - N3RIB7X24K (ioversol)
SB  - IM
MH  - Adult
MH  - Contrast Media/administration & dosage/adverse effects
MH  - Ethiodized Oil/*administration & dosage/adverse effects
MH  - Female
MH  - Genital Diseases, Female/*diagnostic imaging
MH  - Humans
MH  - Hysterosalpingography/methods
MH  - Infertility, Female/diagnostic imaging
MH  - Linear Models
MH  - Middle Aged
MH  - Prospective Studies
MH  - Radiographic Image Enhancement/*methods
MH  - Triiodobenzoic Acids/*administration & dosage/adverse effects
MH  - Young Adult
PMC - PMC6591817
OTO - NOTNLM
OT  - Adverse events
OT  - Ethiodized poppyseed oil
OT  - Hysterosalpingography
OT  - Image quality
OT  - Ioversol
COIS- The authors declare that they have no competing interests.
EDAT- 2019/06/27 06:00
MHDA- 2020/01/14 06:00
PMCR- 2019/06/24
CRDT- 2019/06/26 06:00
PHST- 2018/05/21 00:00 [received]
PHST- 2019/05/29 00:00 [accepted]
PHST- 2019/06/26 06:00 [entrez]
PHST- 2019/06/27 06:00 [pubmed]
PHST- 2020/01/14 06:00 [medline]
PHST- 2019/06/24 00:00 [pmc-release]
AID - 10.1186/s12880-019-0346-0 [pii]
AID - 346 [pii]
AID - 10.1186/s12880-019-0346-0 [doi]
PST - epublish
SO  - BMC Med Imaging. 2019 Jun 24;19(1):50. doi: 10.1186/s12880-019-0346-0.