PMID- 31235122
OWN - NLM
STAT- MEDLINE
DCOM- 20191218
LR  - 20221207
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 13
IP  - 3
DP  - 2019 May-Jun
TI  - Association of glycemic status and interferon-gamma production with leukocytes and 
      platelet indices alterations in type2 diabetes.
PG  - 1963-1969
LID - S1871-4021(19)30229-2 [pii]
LID - 10.1016/j.dsx.2019.04.046 [doi]
AB  - AIMS: The present study aimed to evaluate the correlation between glycemic status 
      and the inflammation biomarkers; leukocytes, platelets indices and interferon 
      gamma (IFN-gamma) production in type 2 diabetes mellitus (T2DM) patients regarding 
      diabetic complications. METHODS: Study was conducted on 158 patients allocated as 
      normal healthy subjects (50) and 108 patients diagnosed as T2DM. The diabetic 
      patients were subdivided into six groups according to metformin administration as 
      mono-or dual therapies. RESULTS: The current results exhibited a significant 
      elevation in systolic blood pressure, total and LDL-cholesterol levels and IFN-gamma 
      as well as a noticeable decrease in HDL-cholesterol and anti-atherogenic factor 
      values compared to the healthy patients. Leukocytes and neutrophils count, main 
      platelets volume (MPV) and platelet distribution width (PDW) values revealed 
      noticeable elevations in most treated T2DM groups, while a marked depletion was 
      recorded in platelets count compared to healthy subjects. Glycemic control, most 
      treated diabetic patients with metformin mono- and dual therapies showed an 
      ameliorative effect in HbA1c, IFN-gamma, MPV, and PDW values compared to recent 
      diabetic ones. CONCLUSION: Diabetes was correlated significantly with 
      dyslipidemia and atherogenic risk in parallel with an increase in IFN-gamma 
      production and hematological inflammatory biomarkers; leukocytes, 
      neutrophil/lymphocyte and platelet/lymphocyte ratios, MPV and PDW values. The 
      amelioration in inflammatory biomarkers was associated with improvement in 
      glycemic control.
CI  - Copyright (c) 2019. Published by Elsevier Ltd.
FAU - Abdel-Moneim, Adel
AU  - Abdel-Moneim A
AD  - Physiology Division, Zoology Department, Faculty of Science, Beni-Suef 
      University, Egypt. Electronic address: adel_men2020@yahoo.com.
FAU - Semmler, Margit
AU  - Semmler M
AD  - Institute, Diabetes Research Dusseldorf University, Dusseldorf, Germany.
FAU - Abdel-Reheim, Eman S
AU  - Abdel-Reheim ES
AD  - Physiology Division, Zoology Department, Faculty of Science, Beni-Suef 
      University, Egypt.
FAU - Zanaty, Mohamed I
AU  - Zanaty MI
AD  - Biotechnology Department, Postgraduate Studies for Advanced Science, Beni-Suef 
      University, Egypt.
FAU - Addaleel, Wessam
AU  - Addaleel W
AD  - Physiology Division, Zoology Department, Faculty of Science, Beni-Suef 
      University, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20190425
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipids)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/*analysis
MH  - Blood Glucose/analysis
MH  - Blood Platelets/*pathology
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/etiology/metabolism/*pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Glycated Hemoglobin/analysis
MH  - Glycemic Index
MH  - Humans
MH  - Interferon-gamma/*blood
MH  - Leukocytes/*pathology
MH  - Lipids/blood
MH  - Lymphocytes/*pathology
MH  - Male
MH  - Mean Platelet Volume
MH  - Middle Aged
MH  - Neutrophils/*pathology
MH  - Prognosis
OTO - NOTNLM
OT  - Diabetic complications
OT  - Glycemic control
OT  - IFN-gamma
OT  - Leukocytes
OT  - Metformin
OT  - Platelets indices
EDAT- 2019/06/27 06:00
MHDA- 2019/12/19 06:00
CRDT- 2019/06/26 06:00
PHST- 2019/04/02 00:00 [received]
PHST- 2019/04/24 00:00 [accepted]
PHST- 2019/06/26 06:00 [entrez]
PHST- 2019/06/27 06:00 [pubmed]
PHST- 2019/12/19 06:00 [medline]
AID - S1871-4021(19)30229-2 [pii]
AID - 10.1016/j.dsx.2019.04.046 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2019 May-Jun;13(3):1963-1969. doi: 
      10.1016/j.dsx.2019.04.046. Epub 2019 Apr 25.