PMID- 31235141
OWN - NLM
STAT- MEDLINE
DCOM- 20191218
LR  - 20221207
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 13
IP  - 3
DP  - 2019 May-Jun
TI  - Kisspeptin and body weight homeostasis in relation to phenotypic features of 
      polycystic ovary syndrome; metabolic regulation of reproduction.
PG  - 2086-2092
LID - S1871-4021(19)30198-5 [pii]
LID - 10.1016/j.dsx.2019.04.017 [doi]
AB  - BACKGROUND: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder 
      characterized by a diverse collection of reproductive and metabolic 
      abnormalities. kisspeptin (KISS) is novel peptides associated with regulation of 
      metabolism, food intake, puberty and reproduction. The aim of the present study 
      was to estimate KISS level in patients with PCOS, and to evaluate the possible 
      relationship between KISS level with anthropometric measures as well as 
      clinic-morphological features of PCOS. MATERIALS AND METHODS: cross section 
      control study enrolled 90 control group and 105 patients with PCOS and they were 
      stratified according to their body mass index (BMI) to; underweight (n = 9, BMI 
      <19), normal weight (n = 25, BMI = 19.1-25), over weight (n = 34,BMI = 25.1-30), 
      obese grade I (n = 12, BMI = 30.1-35) , obese grade II (n = 13, BMI 35.1-40) and 
      obese grade III (n = 12, BMI>40).Circulating KISS levels were measured using 
      ELISA. RESULTS: Our results revealed that, KISS levels were higher in PCOS 
      patients compared to controls. Among PCOS group, there were significant lower 
      level of KISS levels in underweight, overweight and obese compared to normal 
      weight group. Even more importantly, KISS levels decreased with increasing of BMI 
      as the following, grade I, grade II and grade III. Moreover, it was negatively 
      correlated to anthropometric measures, glycemic, lipid profile and positively 
      correlated the phenotype characteristics of PCOS. Linear regression test observed 
      that hirsutism score, HOMA-IR and LH were the main predictors of KISS levels in 
      PCOS. CONCLUSION: circulating KISS is an important regulator of body weight and 
      reproduction especially in PCOS women.
CI  - Copyright (c) 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Rashad, Nearmeen M
AU  - Rashad NM
AD  - Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, 
      Egypt. Electronic address: nrashad78@yahoo.com.
FAU - Al-Sayed, Radwa M
AU  - Al-Sayed RM
AD  - Physiology Department, Faculty of Medicine-Zagazig University, Egypt.
FAU - Yousef, Mohammed S
AU  - Yousef MS
AD  - Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, 
      Egypt.
FAU - Saraya, Yasser S
AU  - Saraya YS
AD  - Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig University, 
      Zagazig, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20190417
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (KISS1 protein, human)
RN  - 0 (Kisspeptins)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Biomarkers/*blood
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - *Body Weight
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Glycated Hemoglobin/analysis
MH  - *Homeostasis
MH  - Humans
MH  - Insulin Resistance
MH  - Kisspeptins/*blood
MH  - Obesity/complications
MH  - Overweight/complications
MH  - Polycystic Ovary Syndrome/*blood/*epidemiology/etiology
MH  - Prognosis
MH  - *Reproduction
MH  - Thinness
OTO - NOTNLM
OT  - Body weight homeostasis
OT  - Kisspeptin
OT  - PCOS
OT  - Phenotypic features
OT  - Reproduction
EDAT- 2019/06/27 06:00
MHDA- 2019/12/19 06:00
CRDT- 2019/06/26 06:00
PHST- 2019/03/17 00:00 [received]
PHST- 2019/04/16 00:00 [accepted]
PHST- 2019/06/26 06:00 [entrez]
PHST- 2019/06/27 06:00 [pubmed]
PHST- 2019/12/19 06:00 [medline]
AID - S1871-4021(19)30198-5 [pii]
AID - 10.1016/j.dsx.2019.04.017 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2019 May-Jun;13(3):2086-2092. doi: 
      10.1016/j.dsx.2019.04.017. Epub 2019 Apr 17.