PMID- 31235420
OWN - NLM
STAT- MEDLINE
DCOM- 20200610
LR  - 20200610
IS  - 1876-4738 (Electronic)
IS  - 0914-5087 (Linking)
VI  - 74
IP  - 5
DP  - 2019 Nov
TI  - Efficacy and safety of exercise rehabilitation in patients with hypertrophic 
      cardiomyopathy.
PG  - 466-472
LID - S0914-5087(19)30140-6 [pii]
LID - 10.1016/j.jjcc.2019.04.013 [doi]
AB  - BACKGROUND: While physical rehabilitation has been shown to be beneficial and 
      safe for patients suffering from heart failure, data on rehabilitation for 
      hypertrophic cardiomyopathy (HCM) patients are limited. METHODS: Forty-five HCM 
      patients participated in an exercise rehabilitation program. Exercise capacity 
      was measured in metabolic equivalent of task (METs) units and functional status 
      was defined according to the New York Heart Association (NYHA). Self-reported 
      measurements addressed the quality of life and daily life function. RESULTS: Of 
      the 45 participants, 32 completed at least 3 months of rehabilitation and had 
      data from two sequential exercise tests. A significant increase in exercise 
      capacity (from mean 5.3 to 6.7 METs, p=0.01), was achieved at higher peak heart 
      rates. Eighteen patients (56%) who showed improvement in exercise capacity did 
      not differ in their NYHA class, clinical, electrocardiographic, or echo-Doppler 
      parameters compared to those who did not improve. The benefit from training was 
      associated with a lower exercise capacity at baseline and was most pronounced in 
      those capable of less than 6.8 METs (p=0.008). No significant arrhythmias or 
      adverse events were recorded in HCM patients during participation. In  approximately 40% of 
      participants, training improved the subjective perception of functional capacity 
      and quality of life; only 4 patients (9%) discontinued their participation due to 
      discomfort during or following training. The improvement in exercise capacity was 
      comparable between HCM and a reference group of dilated cardiomyopathy patients. 
      CONCLUSIONS: Exercise rehabilitation appears to be applicable and safe in HCM. It 
      mainly benefits patients suffering from significant functional limitation. Larger 
      prospective studies are needed to validate these findings and better characterize 
      patients expected to benefit from these programs.
CI  - Copyright (c) 2019 Japanese College of Cardiology. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Wasserstrum, Yishay
AU  - Wasserstrum Y
AD  - Leviev Heart Institute, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, and 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Internal 
      Medicine Department "T", Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, and 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic 
      address: Yishay.Wasserstrum@sheba.gov.il.
FAU - Barbarova, Iryna
AU  - Barbarova I
AD  - Internal Medicine Department "T", Chaim Sheba Medical Center, Tel-Hashomer, Ramat 
      Gan, and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; 
      Meuhedet Health Services HMO, Israel.
FAU - Lotan, Dor
AU  - Lotan D
AD  - Leviev Heart Institute, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, and 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Kuperstein, Rafael
AU  - Kuperstein R
AD  - Leviev Heart Institute, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, and 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Shechter, Michael
AU  - Shechter M
AD  - Leviev Heart Institute, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, and 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Freimark, Dov
AU  - Freimark D
AD  - Leviev Heart Institute, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, and 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Segal, Gad
AU  - Segal G
AD  - Internal Medicine Department "T", Chaim Sheba Medical Center, Tel-Hashomer, Ramat 
      Gan, and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Klempfner, Robert
AU  - Klempfner R
AD  - Leviev Heart Institute, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, and 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Arad, Michael
AU  - Arad M
AD  - Leviev Heart Institute, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, and 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
LA  - eng
PT  - Journal Article
DEP - 20190622
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
SB  - IM
MH  - Adult
MH  - Cardiac Rehabilitation/*methods
MH  - Cardiomyopathy, Hypertrophic/*rehabilitation
MH  - Exercise/physiology
MH  - Exercise Test
MH  - Exercise Therapy/*methods
MH  - Female
MH  - Heart Rate/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Quality of Life
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Exercise testing
OT  - Heart failure
OT  - Hypertrophic cardiomyopathy
OT  - Quality of life
OT  - Rehabilitation
EDAT- 2019/06/27 06:00
MHDA- 2020/06/11 06:00
CRDT- 2019/06/26 06:00
PHST- 2019/01/24 00:00 [received]
PHST- 2019/03/31 00:00 [revised]
PHST- 2019/04/24 00:00 [accepted]
PHST- 2019/06/27 06:00 [pubmed]
PHST- 2020/06/11 06:00 [medline]
PHST- 2019/06/26 06:00 [entrez]
AID - S0914-5087(19)30140-6 [pii]
AID - 10.1016/j.jjcc.2019.04.013 [doi]
PST - ppublish
SO  - J Cardiol. 2019 Nov;74(5):466-472. doi: 10.1016/j.jjcc.2019.04.013. Epub 2019 Jun 
      22.