PMID- 31235762
OWN - NLM
STAT- MEDLINE
DCOM- 20201023
LR  - 20210109
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Jun 24
TI  - High level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy 
      as predictor of risk of malaria during infancy.
PG  - 9160
LID - 10.1038/s41598-019-45688-w [doi]
LID - 9160
AB  - Placental malaria has been associated with an immune tolerance phenomenon and a 
      higher susceptibility to malaria infection during infancy. HLA-G is involved in 
      fetal maternal immune tolerance by inhibiting maternal immunity. During 
      infections HLA-G can be involved in immune escape of pathogens by creating a 
      tolerogenic environment. Recent studies have shown an association between the 
      risk of malaria and HLA-G at both genetic and protein levels. Moreover, women 
      with placental malaria have a higher probability of giving birth to children 
      exhibiting high sHLA-G, independently of their own level during pregnancy. Our 
      aim was to explore the association between the level of maternal soluble HLA-G 
      and the risk of malaria infection in their newborns. Here, 400 pregnant women and 
      their children were actively followed-up during 24 months. The results show a 
      significant association between the level of sHLA-G at the first antenatal visit 
      and the time to first malaria infection during infancy adjusted to the risk of 
      exposure to vector bites (aHR = 1.02, 95%CI [1.01-1.03], p = 0.014). The level of 
      sHLA-G is a significant predictor of the occurrence of malaria infection during 
      infancy consistent with the hypothesis that mother sHLA-G could be a biomarker of 
      malaria susceptibility in children.
FAU - d'Almeida, Tania C
AU  - d'Almeida TC
AD  - Universite Pierre et Marie Curie, Paris VI, France.
AD  - MERIT, IRD, Universite Paris Descartes, Paris, 75006, France.
FAU - Sadissou, Ibrahim
AU  - Sadissou I
AD  - IRD, UMR 261, Centre d'Etude et de Recherche sur le Paludisme Associe a la 
      Grossesse et a l'Enfance (CERPAGE), Faculte des Sciences de la Sante, Cotonou, 
      Benin.
AD  - Division of Clinical Immunology, School of Medicine of Ribeirao Preto, University 
      of Sao Paulo, Sao Paulo, Brazil.
AD  - Universite d'Abomey-Calavi, Cotonou, Benin.
FAU - Sagbohan, Mermoz
AU  - Sagbohan M
AD  - IRD, UMR 261, Centre d'Etude et de Recherche sur le Paludisme Associe a la 
      Grossesse et a l'Enfance (CERPAGE), Faculte des Sciences de la Sante, Cotonou, 
      Benin.
AD  - Universite d'Abomey-Calavi, Cotonou, Benin.
FAU - Milet, Jacqueline
AU  - Milet J
AD  - MERIT, IRD, Universite Paris Descartes, Paris, 75006, France.
FAU - Avokpaho, Euripide
AU  - Avokpaho E
AUID- ORCID: 0000-0003-2321-0505
AD  - IRD, UMR 261, Centre d'Etude et de Recherche sur le Paludisme Associe a la 
      Grossesse et a l'Enfance (CERPAGE), Faculte des Sciences de la Sante, Cotonou, 
      Benin.
FAU - Gineau, Laure
AU  - Gineau L
AD  - MERIT, IRD, Universite Paris Descartes, Paris, 75006, France.
FAU - Sabbagh, Audrey
AU  - Sabbagh A
AD  - MERIT, IRD, Universite Paris Descartes, Paris, 75006, France.
FAU - Moutairou, Kabirou
AU  - Moutairou K
AD  - Universite d'Abomey-Calavi, Cotonou, Benin.
FAU - Donadi, Eduardo A
AU  - Donadi EA
AD  - Division of Clinical Immunology, School of Medicine of Ribeirao Preto, University 
      of Sao Paulo, Sao Paulo, Brazil.
FAU - Favier, Benoit
AU  - Favier B
AD  - Commissariat a l'Energie Atomique et aux Energies Alternatives, Direction de la 
      Recherche Fondamentale, Institut de Biologie Francois Jacob, Service de 
      Recherches en Hemato-Immunologie, Hopital Saint-Louis, IUH, Paris, France.
AD  - Universite Paris Diderot, Sorbonne Paris Cite, IUH, Hopital Saint-Louis, UMR_E5, 
      IUH, Paris, France.
FAU - Pennetier, Cedric
AU  - Pennetier C
AD  - UMR MIVEGEC (IRD-CNRS-UM), Montpellier, France.
AD  - Centre de Recherche Entomologiques de Cotonou (CREC), Cotonou, Benin.
FAU - Baldet, Thierry
AU  - Baldet T
AD  - UMR MIVEGEC (IRD-CNRS-UM), Montpellier, France.
AD  - Centre de Recherche Entomologiques de Cotonou (CREC), Cotonou, Benin.
FAU - Moiroux, Nicolas
AU  - Moiroux N
AUID- ORCID: 0000-0001-6755-6167
AD  - UMR MIVEGEC (IRD-CNRS-UM), Montpellier, France.
AD  - Centre de Recherche Entomologiques de Cotonou (CREC), Cotonou, Benin.
FAU - Carosella, Edgardo
AU  - Carosella E
AD  - Commissariat a l'Energie Atomique et aux Energies Alternatives, Direction de la 
      Recherche Fondamentale, Institut de Biologie Francois Jacob, Service de 
      Recherches en Hemato-Immunologie, Hopital Saint-Louis, IUH, Paris, France.
AD  - Universite Paris Diderot, Sorbonne Paris Cite, IUH, Hopital Saint-Louis, UMR_E5, 
      IUH, Paris, France.
FAU - Moreau, Philippe
AU  - Moreau P
AD  - Commissariat a l'Energie Atomique et aux Energies Alternatives, Direction de la 
      Recherche Fondamentale, Institut de Biologie Francois Jacob, Service de 
      Recherches en Hemato-Immunologie, Hopital Saint-Louis, IUH, Paris, France.
AD  - Universite Paris Diderot, Sorbonne Paris Cite, IUH, Hopital Saint-Louis, UMR_E5, 
      IUH, Paris, France.
FAU - Rouas-Freiss, Nathalie
AU  - Rouas-Freiss N
AD  - Commissariat a l'Energie Atomique et aux Energies Alternatives, Direction de la 
      Recherche Fondamentale, Institut de Biologie Francois Jacob, Service de 
      Recherches en Hemato-Immunologie, Hopital Saint-Louis, IUH, Paris, France.
AD  - Universite Paris Diderot, Sorbonne Paris Cite, IUH, Hopital Saint-Louis, UMR_E5, 
      IUH, Paris, France.
FAU - Cottrell, Gilles
AU  - Cottrell G
AD  - MERIT, IRD, Universite Paris Descartes, Paris, 75006, France.
AD  - IRD, UMR 261, Centre d'Etude et de Recherche sur le Paludisme Associe a la 
      Grossesse et a l'Enfance (CERPAGE), Faculte des Sciences de la Sante, Cotonou, 
      Benin.
FAU - Courtin, David
AU  - Courtin D
AD  - MERIT, IRD, Universite Paris Descartes, Paris, 75006, France.
FAU - Garcia, Andre
AU  - Garcia A
AD  - MERIT, IRD, Universite Paris Descartes, Paris, 75006, France. 
      andre.garcia@ird.fr.
AD  - IRD, UMR 261, Centre d'Etude et de Recherche sur le Paludisme Associe a la 
      Grossesse et a l'Enfance (CERPAGE), Faculte des Sciences de la Sante, Cotonou, 
      Benin. andre.garcia@ird.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190624
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Adult
MH  - Female
MH  - HLA-G Antigens/*chemistry/*metabolism
MH  - Humans
MH  - Infant
MH  - Malaria/*epidemiology
MH  - Male
MH  - Pregnancy
MH  - Proportional Hazards Models
MH  - Risk Assessment
MH  - Solubility
PMC - PMC6591392
COIS- The authors declare no competing interests.
EDAT- 2019/06/27 06:00
MHDA- 2020/10/24 06:00
PMCR- 2019/06/24
CRDT- 2019/06/26 06:00
PHST- 2019/01/15 00:00 [received]
PHST- 2019/06/11 00:00 [accepted]
PHST- 2019/06/26 06:00 [entrez]
PHST- 2019/06/27 06:00 [pubmed]
PHST- 2020/10/24 06:00 [medline]
PHST- 2019/06/24 00:00 [pmc-release]
AID - 10.1038/s41598-019-45688-w [pii]
AID - 45688 [pii]
AID - 10.1038/s41598-019-45688-w [doi]
PST - epublish
SO  - Sci Rep. 2019 Jun 24;9(1):9160. doi: 10.1038/s41598-019-45688-w.