PMID- 31236282
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2055-1169 (Electronic)
IS  - 2055-1169 (Linking)
VI  - 5
IP  - 1
DP  - 2019 Jan-Jun
TI  - Colonic malignant peripheral nerve sheath tumour in a cat.
PG  - 2055116919849979
LID - 10.1177/2055116919849979 [doi]
LID - 2055116919849979
AB  - CASE SUMMARY: A 14-year-old male neutered domestic mediumhair cat presented with 
      a 4 month history of inappetence and weight loss. Pertinent abnormalities on 
      haematology and biochemistry included a mild microcytic regenerative anaemia 
      (packed cell volume [PCV] 24% [reference interval (RI) 30-45%], mean cell volume 
      30.8 fl [RI 40-45 fl], absolute reticulocyte count 326.8 x 10(12)) and increased 
      alkaline phosphatase activity (76 IU/l; RI <50 IU/l). Abdominal ultrasound and CT 
      scan revealed masses in the transverse colon (2.0 cm x 1.2 cm) and right medial 
      liver lobe (5.0 cm diameter). Thoracic radiographs were unremarkable. Right 
      medial liver lobe resection and colectomy were performed. Immunohistochemistry 
      was positive for S-100 protein, vimentin and glial fibrillary acidic protein, 
      very weakly positive for c-kit and negative for muscle-specific actin and CD18, 
      consistent with a colonic malignant peripheral nerve sheath tumour (MPNST) with a 
      hepatic metastasis. Postoperative treatment with metronomic cyclophosphamide was 
      well tolerated. Eighteen months postoperatively the cat re-presented after 3 days 
      of progressive lethargy and inappetence. Haematology revealed a marked non- or 
      pre-regenerative anaemia (PCV 10%). Coagulation times were prolonged (prothrombin 
      time 39 s [RI 15-22 s] and activated partial thromboplastin time >300 s [RI 
      65-119 s]). Abdominal ultrasound identified multiple renal and hepatic nodules. 
      Euthanasia was performed and post-mortem examination confirmed metastasis of the 
      MPNST. RELEVANCE AND NOVEL INFORMATION: This report describes the treatment of a 
      metastatic colonic peripheral nerve sheath tumour in a cat. Feline visceral 
      MPNSTs are rare and little is known about prognosis or optimal treatment.
FAU - Boland, Lara
AU  - Boland L
AD  - Valentine Charlton Cat Centre, Sydney School of Veterinary Science, Faculty of 
      Science, University of Sydney, NSW, Australia.
FAU - Setyo, Laura
AU  - Setyo L
AD  - Veterinary Pathology Diagnostic Services, Sydney School of Veterinary Science, 
      Faculty of Science, University of Sydney, NSW, Australia.
FAU - Sangster, Cheryl
AU  - Sangster C
AD  - Veterinary Pathology Diagnostic Services, Sydney School of Veterinary Science, 
      Faculty of Science, University of Sydney, NSW, Australia.
FAU - Brunel, Laurencie
AU  - Brunel L
AD  - Valentine Charlton Cat Centre, Sydney School of Veterinary Science, Faculty of 
      Science, University of Sydney, NSW, Australia.
FAU - Foo, Timothy
AU  - Foo T
AD  - Valentine Charlton Cat Centre, Sydney School of Veterinary Science, Faculty of 
      Science, University of Sydney, NSW, Australia.
FAU - Bennett, Peter
AU  - Bennett P
AUID- ORCID: 0000-0002-7209-4996
AD  - Valentine Charlton Cat Centre, Sydney School of Veterinary Science, Faculty of 
      Science, University of Sydney, NSW, Australia.
LA  - eng
PT  - Case Reports
DEP - 20190528
PL  - England
TA  - JFMS Open Rep
JT  - JFMS open reports
JID - 101672978
PMC - PMC6572897
OTO - NOTNLM
OT  - Peripheral nerve sheath tumour
OT  - cyclophosphamide
OT  - metastasis
OT  - metronomic chemotherapy
COIS- Conflict of interest: The authors declared no potential conflicts of interest 
      with respect to the research, authorship, and/or publication of this article.
EDAT- 2019/06/27 06:00
MHDA- 2019/06/27 06:01
PMCR- 2019/05/28
CRDT- 2019/06/26 06:00
PHST- 2019/06/26 06:00 [entrez]
PHST- 2019/06/27 06:00 [pubmed]
PHST- 2019/06/27 06:01 [medline]
PHST- 2019/05/28 00:00 [pmc-release]
AID - 10.1177_2055116919849979 [pii]
AID - 10.1177/2055116919849979 [doi]
PST - epublish
SO  - JFMS Open Rep. 2019 May 28;5(1):2055116919849979. doi: 10.1177/2055116919849979. 
      eCollection 2019 Jan-Jun.