PMID- 31236629
OWN - NLM
STAT- MEDLINE
DCOM- 20200127
LR  - 20200307
IS  - 1432-1173 (Electronic)
IS  - 0017-8470 (Linking)
VI  - 71
IP  - 1
DP  - 2020 Jan
TI  - [Bullous pemphigoid on a healed herpes zoster : A rare example of an isotopic 
      response].
PG  - 53-56
LID - 10.1007/s00105-019-4445-1 [doi]
AB  - Wolf's isotopic response describes the eruption of a secondary, pathogenically 
      independent skin disease within the borders of a primary, already healed skin 
      disease. The exact mechanism is unknown, but the restriction to diseases with 
      a known T‑cell component in the pathogenesis suggests an involvement of 
      persistent local immune activation. We report the case of an 87-year-old woman 
      who developed bullous pemphigoid lesions within the boundaries of a previous, 
      already healed herpes zoster C7-C8, which had been diagnosed clinically and 
      treated 2 months previously. Histopathological examination revealed subepidermal 
      blisters, and indirect immunofluorescence showed IgG antibodies against the basal 
      membrane zone. Both BP 180 and BP 230 enzyme-linked immunoassays (ELISAs) were 
      positive. Based on these findings, we diagnosed a bullous pemphigoid arising on 
      the site of the already healed herpes zoster, linked by an isotopic response.
FAU - Bohmer, D
AU  - Bohmer D
AD  - Klinik und Poliklinik fur Dermatologie und Allergologie, LMU, Frauenlobstr. 9, 
      80337, Munchen, Deutschland.
FAU - Seegraber, M
AU  - Seegraber M
AD  - Klinik und Poliklinik fur Dermatologie und Allergologie, LMU, Frauenlobstr. 9, 
      80337, Munchen, Deutschland.
FAU - Horvath, O N
AU  - Horvath ON
AD  - Klinik und Poliklinik fur Dermatologie und Allergologie, LMU, Frauenlobstr. 9, 
      80337, Munchen, Deutschland.
FAU - Wollenberg, A
AU  - Wollenberg A
AD  - Klinik und Poliklinik fur Dermatologie und Allergologie, LMU, Frauenlobstr. 9, 
      80337, Munchen, Deutschland. wollenberg@lrz.uni-muenchen.de.
AD  - Stadtisches Klinikum Thalkirchner Strasse, Munchen, Deutschland. 
      wollenberg@lrz.uni-muenchen.de.
LA  - ger
PT  - Case Reports
PT  - Journal Article
TT  - Bulloses Pemphigoid auf einem ausgeheilten Zoster thoracalis : Ein seltenes 
      Fallbeispiel fur eine isotope Reaktion.
PL  - Germany
TA  - Hautarzt
JT  - Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
JID - 0372755
SB  - IM
MH  - Aged, 80 and over
MH  - Female
MH  - *Herpes Zoster/complications
MH  - Humans
MH  - *Pemphigoid, Bullous/complications
MH  - Skin
OTO - NOTNLM
OT  - Herpes zoster
OT  - Histology
OT  - Local immune activation
OT  - Secondary disease
OT  - T-cell-mediated dermatoses
EDAT- 2019/06/27 06:00
MHDA- 2020/01/28 06:00
CRDT- 2019/06/26 06:00
PHST- 2019/06/27 06:00 [pubmed]
PHST- 2020/01/28 06:00 [medline]
PHST- 2019/06/26 06:00 [entrez]
AID - 10.1007/s00105-019-4445-1 [pii]
AID - 10.1007/s00105-019-4445-1 [doi]
PST - ppublish
SO  - Hautarzt. 2020 Jan;71(1):53-56. doi: 10.1007/s00105-019-4445-1.