PMID- 31238058
OWN - NLM
STAT- MEDLINE
DCOM- 20191114
LR  - 20191114
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 154
DP  - 2019 Aug
TI  - Predictors of cardiomyopathy in patients with type-2 diabetes mellitus with and 
      without cardiovascular complications: A cross-sectional study.
PG  - 90-100
LID - S0168-8227(19)30626-6 [pii]
LID - 10.1016/j.diabres.2019.06.012 [doi]
AB  - AIM: This study was aimed to evaluate the cardiomyopathy in patients with type 2 
      diabetes mellitus (T2DM) who live with or without cardiovascular complications by 
      estimating different cardiac biomarkers. METHODS: This cross-sectional study 
      enrolled 125 participants including 25 healthy volunteers and 100 T2DM patients. 
      After meeting all inclusion criteria, the participants were categorized into five 
      groups (N = 25 in each) as; healthy volunteers (I), T2DM (II), T2DM with 
      hypertension (III), T2DM with dyslipidemia (IV), T2DM with hypertension and 
      dyslipidemia (V). Pearson's correlation analysis was performed to assess the 
      significant association between cardiac biomarkers other biochemical parameters. 
      P-values <0.05 were considered statistically significant. RESULTS: The average 
      age of the participants was found to be 55.04 +/- 7.51 years. The positive 
      correlation was found between HbA1c and calcium or BNP levels however, a negative 
      association was observed with zinc level. Group V showed higher mean of BNP 
      (pg/mL) as 86.73 +/- 64.49 followed by Group III (61.02 +/- 53.69), IV 
      (33.88 +/- 33.71), II (13.49 +/- 11.67) and I (5.54 +/- 1.49) which predicts the 
      subclinical cardiomyopathies in the respective groups. Serum zinc (microg/dL) level 
      were significantly lower in Group V (52.72 +/- 12.16) followed by III 
      (56.15 +/- 9.64), IV (58.10 +/- 10.05), II (59.49 +/- 11.33) and I (73.96 +/- 21.91). 
      CONCLUSIONS: In summary, BNP and calcium levels were significantly elevated while 
      zinc was significantly reduced in T2DM patients with cardiovascular complication. 
      Results from the study also shown positive correlation between BNP, calcium, 
      Troponin-I levels and blood pressure. However, further longitudinal studies 
      required to confirm these findings.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Bashir, Aamir
AU  - Bashir A
AD  - Department of Pharmacy Practice, National Institute of Pharmaceutical Education 
      and Research, Hajipur 844102, Bihar, India.
FAU - Azharuddin, Md
AU  - Azharuddin M
AD  - Department of Pharmaceutical Medicine (Division of Pharmacology), School of 
      Pharmaceutical Education and Research, Jamia Hamdard, 110062 New Delhi, India.
FAU - Rashid, Ishfaq
AU  - Rashid I
AD  - Department of Pharmacy Practice, National Institute of Pharmaceutical Education 
      and Research, SAS Nagar, 160062 Punjab, India.
FAU - Murti, Krishna
AU  - Murti K
AD  - Department of Pharmacy Practice, National Institute of Pharmaceutical Education 
      and Research, Hajipur 844102, Bihar, India. Electronic address: 
      krishnamurti74@gmail.com.
FAU - Pandey, Krishna
AU  - Pandey K
AD  - Division of Clinical Medicine, Rajendra Memorial Research Institute of Medical 
      Sciences (Indian Council of Medical Research), Agamkuan, Patna, 800007 Bihar, 
      India. Electronic address: drkrishnapandey@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20190622
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers/*analysis
MH  - Cardiomyopathies/*diagnosis/etiology/metabolism
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Dyslipidemias/*physiopathology
MH  - Female
MH  - Humans
MH  - Hypertension/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
EDAT- 2019/06/27 06:00
MHDA- 2019/11/15 06:00
CRDT- 2019/06/26 06:00
PHST- 2019/05/08 00:00 [received]
PHST- 2019/05/29 00:00 [revised]
PHST- 2019/06/18 00:00 [accepted]
PHST- 2019/06/27 06:00 [pubmed]
PHST- 2019/11/15 06:00 [medline]
PHST- 2019/06/26 06:00 [entrez]
AID - S0168-8227(19)30626-6 [pii]
AID - 10.1016/j.diabres.2019.06.012 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2019 Aug;154:90-100. doi: 10.1016/j.diabres.2019.06.012. 
      Epub 2019 Jun 22.