PMID- 31240435 OWN - NLM STAT- MEDLINE DCOM- 20200929 LR - 20221122 IS - 1435-5922 (Electronic) IS - 0944-1174 (Linking) VI - 54 IP - 12 DP - 2019 Dec TI - Familial pancreatic cancer risk: a population-based study in Utah. PG - 1106-1112 LID - 10.1007/s00535-019-01597-3 [doi] AB - INTRODUCTION: Pancreas adenocarcinoma (PC) has an undefined hereditary component. We quantified the familial risk of PC among relatives of patients diagnosed with PC and stratified it based on anatomic location of PC and age and sex of the proband. METHODS: This is a retrospective, population-based, case-control study of PC diagnosed in Utah between 1980 and 2011. The Utah population database and cancer registry were used to identify index patients with PC. The risk of PC in first-degree relatives (FDRs), second-degree relatives (SDRs), and first cousins (FCs) of probands was compared with randomly selected sex- and age-matched population controls. RESULTS: A total of 4,095 patients and 40,933 controls were identified. The relative risk (RR) of PC was 1.76 (95% CI 1.35-2.29) in FDRs, 1.42 (95% CI 1.18-1.7) in SDRs and 1.08 (95% CI 0.95-1.23) in FCs of probands compared to relatives of PC-free controls. The RR were elevated in FDRs (1.96, 95% CI 1.45-2.65), SDRs (1.54, 95% CI 1.19-1.98) and FCs (1.18, 95% CI 1.0-1.64) of female probands. Among probands diagnosed as < 65 years, RR was 2.12 (95% CI 1.37-3.28) in FDRs, 1.94 (95% CI 1.44-2.62) in SDRs, and 1.28 (95% CI 1.0-1.64) in FCs. Overall, the RR for PC was elevated in FDRs regardless of the anatomic location of PC. DISCUSSION: There is an increased risk of PC in FDR and more distant relatives of patients with PC. Relatives of female patients with PC and patients diagnosed at age < 65 years are at a significantly increased risk of PC. FAU - Kohli, Divyanshoo R AU - Kohli DR AUID- ORCID: 0000-0002-7801-0044 AD - Division of Gastroenterology and Hepatology, Mayo Clinic, 13400 E Shea Blvd, Scottsdale, AZ, 85259, USA. AD - Division of Gastroenterology and Hepatology, Kansas City Veterans Affairs Medical Center, Kansas City, MO, USA. FAU - Smith, Ken Robert AU - Smith KR AD - Department of Medicine (Gastroenterology), Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. AD - Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. AD - Department of Medicine (Genetic Epidemiology), Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. FAU - Wong, Jathine AU - Wong J AD - Department of Medicine (Gastroenterology), Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. AD - Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. AD - Department of Medicine (Genetic Epidemiology), Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. FAU - Yu, Zhe AU - Yu Z AD - Department of Medicine (Gastroenterology), Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. AD - Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. AD - Department of Medicine (Genetic Epidemiology), Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. FAU - Boucher, Kenneth AU - Boucher K AD - Department of Medicine (Gastroenterology), Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. AD - Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. AD - Department of Medicine (Genetic Epidemiology), Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. FAU - Faigel, Douglas O AU - Faigel DO AD - Division of Gastroenterology and Hepatology, Mayo Clinic, 13400 E Shea Blvd, Scottsdale, AZ, 85259, USA. FAU - Pannala, Rahul AU - Pannala R AD - Division of Gastroenterology and Hepatology, Mayo Clinic, 13400 E Shea Blvd, Scottsdale, AZ, 85259, USA. FAU - Burt, Randall W AU - Burt RW AD - Department of Medicine (Gastroenterology), Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. AD - Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. AD - Department of Medicine (Genetic Epidemiology), Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. FAU - Curtin, Karen AU - Curtin K AD - Department of Medicine (Gastroenterology), Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. AD - Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. AD - Department of Medicine (Genetic Epidemiology), Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. FAU - Samadder, N Jewel AU - Samadder NJ AD - Division of Gastroenterology and Hepatology, Mayo Clinic, 13400 E Shea Blvd, Scottsdale, AZ, 85259, USA. Samadder.jewel@mayo.edu. LA - eng GR - R01 RR021746/RR/NCRR NIH HHS/United States GR - P01-CA073992/CA/NCI NIH HHS/United States GR - P30CA042014/CA/NCI NIH HHS/United States GR - R01-CA040641/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20190625 PL - Japan TA - J Gastroenterol JT - Journal of gastroenterology JID - 9430794 RN - Pancreatic carcinoma, familial SB - IM MH - Adenocarcinoma/*epidemiology/pathology MH - Adolescent MH - Adult MH - Age Factors MH - Aged MH - Aged, 80 and over MH - Carcinoma/*epidemiology/pathology MH - Case-Control Studies MH - Family Health MH - Female MH - Humans MH - Male MH - Middle Aged MH - Pancreatic Neoplasms/*epidemiology/pathology MH - Registries MH - Retrospective Studies MH - Risk Factors MH - Sex Factors MH - Utah/epidemiology MH - Young Adult OTO - NOTNLM OT - Familial OT - Hereditary cancer OT - Pancreatic cancer EDAT- 2019/06/27 06:00 MHDA- 2020/09/30 06:00 CRDT- 2019/06/27 06:00 PHST- 2019/03/07 00:00 [received] PHST- 2019/06/03 00:00 [accepted] PHST- 2019/06/27 06:00 [pubmed] PHST- 2020/09/30 06:00 [medline] PHST- 2019/06/27 06:00 [entrez] AID - 10.1007/s00535-019-01597-3 [pii] AID - 10.1007/s00535-019-01597-3 [doi] PST - ppublish SO - J Gastroenterol. 2019 Dec;54(12):1106-1112. doi: 10.1007/s00535-019-01597-3. Epub 2019 Jun 25.