PMID- 31242053
OWN - NLM
STAT- MEDLINE
DCOM- 20201221
LR  - 20210312
IS  - 2047-4881 (Electronic)
IS  - 2047-4873 (Print)
IS  - 2047-4873 (Linking)
VI  - 27
IP  - 1
DP  - 2020 Jan
TI  - Acute impact of an endurance race on cardiac function and biomarkers of 
      myocardial injury in triathletes with and without myocardial fibrosis.
PG  - 94-104
LID - 10.1177/2047487319859975 [doi]
AB  - AIMS: The aim of this study was to investigate the occurrence of myocardial 
      injury and cardiac dysfunction after an endurance race by biomarkers and cardiac 
      magnetic resonance in triathletes with and without myocardial fibrosis. METHODS 
      AND RESULTS: Thirty asymptomatic male triathletes (45 +/- 10 years) with over 10 
      training hours per week and 55 +/- 8 ml/kg per minute maximal oxygen uptake during 
      exercise testing were studied before (baseline) and 2.4 +/- 1.1 hours post-race. 
      Baseline cardiac magnetic resonance included cine, T1/T2, late gadolinium 
      enhancement (LGE) and extracellular volume imaging. Post-race non-contrast 
      cardiac magnetic resonance included cine and T1/T2 mapping. Non-ischaemic 
      myocardial fibrosis was present in 10 triathletes (LGE+) whereas 20 had no 
      fibrosis (LGE-). At baseline, LGE + triathletes had higher peak exercise systolic 
      blood pressure with 222 +/- 21 mmHg compared to LGE- triathletes (192 +/- 30 mmHg, 
      P < 0.01). Post-race troponin T and creatine kinase MB were similarly increased 
      in both groups, but there was no change in T2 and T1 from baseline to post-race 
      with 54 +/- 3 ms versus 53 +/- 3 ms (P = 0.797) and 989 +/- 21 ms versus 989 +/- 28 ms 
      (P = 0.926), respectively. However, post-race left atrial ejection fraction was 
      significantly lower in LGE + triathletes compared to LGE- triathletes (53 +/- 6% 
      vs. 59 +/- 6%, P < 0.05). Furthermore, baseline atrial peak filling rates were 
      lower in LGE -  triathletes (121 +/- 30 ml/s/m(2)) compared to LGE + triathletes 
      (161 +/- 34 ml/s/m(2), P < 0.01). Post-race atrial peak filling rates increased in 
      LGE- triathletes to 163 +/- 46 ml/s/m(2), P < 0.001), but not in LGE + triathletes 
      (169 +/- 50ml/s/m(2), P = 0.747). CONCLUSION: Despite post-race troponin T release, 
      we did not find detectable myocardial oedema by cardiac magnetic resonance. 
      However, the unfavourable blood pressure response during exercise testing seemed 
      to be associated with post-race cardiac dysfunction, which could explain the 
      occurrence of myocardial fibrosis in triathletes.
FAU - Tahir, Enver
AU  - Tahir E
AD  - Department of Diagnostic and Interventional Radiology and Nuclear Medicine, 
      University Hospital Hamburg-Eppendorf, Germany.
FAU - Scherz, Benedikt
AU  - Scherz B
AD  - Department of Diagnostic and Interventional Radiology and Nuclear Medicine, 
      University Hospital Hamburg-Eppendorf, Germany.
FAU - Starekova, Jitka
AU  - Starekova J
AD  - Department of Diagnostic and Interventional Radiology and Nuclear Medicine, 
      University Hospital Hamburg-Eppendorf, Germany.
FAU - Muellerleile, Kai
AU  - Muellerleile K
AD  - Department of General and Interventional Cardiology, University Heart Center, 
      Germany.
FAU - Fischer, Roland
AU  - Fischer R
AD  - Department of Pediatric Hematology and Oncology, University Hospital 
      Hamburg-Eppendorf, Germany.
AD  - UCSF, Benioff Children's Hospital Oakland, USA.
FAU - Schoennagel, Bjorn
AU  - Schoennagel B
AD  - Department of Diagnostic and Interventional Radiology and Nuclear Medicine, 
      University Hospital Hamburg-Eppendorf, Germany.
FAU - Warncke, Malte
AU  - Warncke M
AD  - Department of Diagnostic and Interventional Radiology and Nuclear Medicine, 
      University Hospital Hamburg-Eppendorf, Germany.
FAU - Stehning, Christian
AU  - Stehning C
AD  - Philips Clinical Science, Germany.
FAU - Cavus, Ersin
AU  - Cavus E
AD  - Department of General and Interventional Cardiology, University Heart Center, 
      Germany.
FAU - Bohnen, Sebastian
AU  - Bohnen S
AD  - Department of General and Interventional Cardiology, University Heart Center, 
      Germany.
FAU - Radunski, Ulf K
AU  - Radunski UK
AD  - Department of General and Interventional Cardiology, University Heart Center, 
      Germany.
FAU - Blankenberg, Stefan
AU  - Blankenberg S
AD  - Department of General and Interventional Cardiology, University Heart Center, 
      Germany.
FAU - Simon, Perikles
AU  - Simon P
AD  - Department of Sports Medicine, Johannes Gutenberg University Mainz, Germany.
FAU - Pressler, Axel
AU  - Pressler A
AD  - Department of Prevention, Rehabilitation and Sports Medicine, Technische 
      Universitat Munchen, Germany.
AD  - Center of Sports and Preventive Cardiology, Germany.
FAU - Adam, Gerhard
AU  - Adam G
AD  - Department of Diagnostic and Interventional Radiology and Nuclear Medicine, 
      University Hospital Hamburg-Eppendorf, Germany.
FAU - Patten, Monica
AU  - Patten M
AD  - UCSF, Benioff Children's Hospital Oakland, USA.
FAU - Lund, Gunnar K
AU  - Lund GK
AD  - Department of Diagnostic and Interventional Radiology and Nuclear Medicine, 
      University Hospital Hamburg-Eppendorf, Germany.
LA  - eng
PT  - Journal Article
DEP - 20190626
PL  - England
TA  - Eur J Prev Cardiol
JT  - European journal of preventive cardiology
JID - 101564430
RN  - 0 (Biomarkers)
RN  - 0 (Troponin T)
RN  - EC 2.7.3.2 (Creatine Kinase, MB Form)
SB  - IM
CIN - Eur J Prev Cardiol. 2020 Jan;27(1):89-93. PMID: 31412714
CIN - Eur J Prev Cardiol. 2019 Aug 31;:2047487319871114. PMID: 31475578
CIN - Eur J Prev Cardiol. 2019 Nov;26(16):1783-1784. PMID: 31488000
MH  - Adolescent
MH  - Adult
MH  - Bicycling
MH  - Biomarkers/blood
MH  - Blood Pressure
MH  - Cardiomyopathies/blood/diagnostic imaging/*etiology/physiopathology
MH  - Case-Control Studies
MH  - Creatine Kinase, MB Form/*blood
MH  - Edema, Cardiac/blood/diagnostic imaging/*etiology/physiopathology
MH  - Fibrosis
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - *Physical Endurance
MH  - Predictive Value of Tests
MH  - Running
MH  - Swimming
MH  - Time Factors
MH  - Troponin T/*blood
MH  - *Ventricular Function, Left
MH  - *Ventricular Function, Right
MH  - Young Adult
PMC - PMC6923712
OTO - NOTNLM
OT  - Athlete's heart
OT  - T2 and T1 mapping
OT  - cardiac magnetic resonance
OT  - late gadolinium enhancement
OT  - myocardial fibrosis
OT  - post-race cardiac function
OT  - post-race myocardial oedema
EDAT- 2019/06/27 06:00
MHDA- 2020/12/22 06:00
PMCR- 2019/12/20
CRDT- 2019/06/27 06:00
PHST- 2019/06/27 06:00 [pubmed]
PHST- 2020/12/22 06:00 [medline]
PHST- 2019/06/27 06:00 [entrez]
PHST- 2019/12/20 00:00 [pmc-release]
AID - 10.1177_2047487319859975 [pii]
AID - 10.1177/2047487319859975 [doi]
PST - ppublish
SO  - Eur J Prev Cardiol. 2020 Jan;27(1):94-104. doi: 10.1177/2047487319859975. Epub 
      2019 Jun 26.