PMID- 31242396
OWN - NLM
STAT- MEDLINE
DCOM- 20200106
LR  - 20200106
IS  - 1480-3275 (Electronic)
IS  - 0008-4166 (Linking)
VI  - 65
IP  - 11
DP  - 2019 Nov
TI  - Continuing surveillance of invasive Haemophilus influenzae disease in 
      northwestern Ontario emphasizes the importance of serotype a and non-typeable 
      strains as causes of serious disease: a Canadian Immunization Research Network 
      (CIRN) Study.
PG  - 805-813
LID - 10.1139/cjm-2019-0210 [doi]
AB  - In the post-Haemophilus influenzae serotype b (Hib) vaccine era, invasive H. 
      influenzae serotype a (Hia) disease emerged in Canadian First Nation, Inuit, and 
      Alaskan Indigenous populations. Previous studies by our group found a high 
      incidence of invasive Hia disease in northwestern Ontario. We retrospectively 
      reviewed 24 cases (4 pediatric and 20 adult) of invasive H. influenzae disease 
      hospitalized at the northwestern Ontario regional hospital between August 2011 
      and June 2018. The objectives were to further document the changing epidemiology 
      of invasive H. influenzae disease in the region and to discuss potential control 
      measures. Twenty-two H. influenzae isolates were serotyped and characterized 
      using molecular-biological methods. Of the serotyped cases, there were 2 Hib, 9 
      Hia, and 11 non-typeable (NTHi). All Hia isolates belonged to the most common 
      sequence types (ST) found in Canada (ST-23 and ST-929); 8 out of 9 were pan 
      susceptible to antibiotics. One (11%) of 9 Hia and 5 (45%) of 11 NTHi cases were 
      fatal. Our data on the consistent presence of serious invasive H. influenzae 
      disease, with 41% prevalence of Hia (9 out of 22 serotyped isolates) and 50% 
      prevalence of NTHi strains (11 out of 22), emphasize the importance of continued 
      surveillance of H. influenzae in the post-Hib vaccine era and are critical 
      information to inform potential vaccine development.
FAU - Cerqueira, Ashley
AU  - Cerqueira A
AD  - Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
FAU - Byce, Sarah
AU  - Byce S
AD  - Faculty of Medicine, Northern Ontario School of Medicine, Thunder Bay, Ontario, 
      Canada.
FAU - Tsang, Raymond S W
AU  - Tsang RSW
AD  - Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public 
      Health Agency of Canada, Winnipeg, Manitoba, Canada.
FAU - Jamieson, Frances B
AU  - Jamieson FB
AD  - Public Health Laboratories, Public Health Ontario, Toronto, Ontario, Canada.
AD  - Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, 
      University of Toronto, Toronto, Ontario, Canada.
FAU - Kus, Julianne V
AU  - Kus JV
AD  - Public Health Laboratories, Public Health Ontario, Toronto, Ontario, Canada.
AD  - Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, 
      University of Toronto, Toronto, Ontario, Canada.
FAU - Ulanova, Marina
AU  - Ulanova M
AD  - Division of Medical Sciences, Northern Ontario School of Medicine, Thunder Bay, 
      Ontario, Canada.
LA  - eng
PT  - Journal Article
DEP - 20190626
PL  - Canada
TA  - Can J Microbiol
JT  - Canadian journal of microbiology
JID - 0372707
RN  - 0 (Haemophilus Vaccines)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child, Preschool
MH  - Epidemiological Monitoring
MH  - Haemophilus Infections/epidemiology/immunology/*microbiology/prevention & control
MH  - Haemophilus Vaccines/*administration & dosage/immunology
MH  - Haemophilus influenzae/classification/genetics/immunology/*isolation & 
      purification
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Middle Aged
MH  - Ontario/epidemiology
MH  - Retrospective Studies
MH  - Serogroup
MH  - Vaccination
MH  - Young Adult
OTO - NOTNLM
OT  - Haemophilus influenzae
OT  - antibiotic susceptibility
OT  - infection
OT  - sensibilite aux antibiotiques
OT  - serotype
OT  - serotype
EDAT- 2019/06/27 06:00
MHDA- 2020/01/07 06:00
CRDT- 2019/06/27 06:00
PHST- 2019/06/27 06:00 [pubmed]
PHST- 2020/01/07 06:00 [medline]
PHST- 2019/06/27 06:00 [entrez]
AID - 10.1139/cjm-2019-0210 [doi]
PST - ppublish
SO  - Can J Microbiol. 2019 Nov;65(11):805-813. doi: 10.1139/cjm-2019-0210. Epub 2019 
      Jun 26.