PMID- 31242791
OWN - NLM
STAT- MEDLINE
DCOM- 20201116
LR  - 20201116
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 30
IP  - 4
DP  - 2020 Jul
TI  - Human leukocyte antigen in Japanese patients with idiopathic inflammatory 
      myopathy.
PG  - 696-702
LID - 10.1080/14397595.2019.1637593 [doi]
AB  - Objective: The human leukocyte antigen (HLA) is the strongest genetic risk factor 
      for idiopathic inflammatory myopathy (IIM), and different HLA alleles have been 
      reported to be associated with IIM susceptibility among different ethnic groups. 
      In this study, we have investigated HLA alleles associated with IIM in Japanese 
      patients.Methods: Genotyping of HLA-DRB1 and DPB1 were performed in 252 Japanese 
      IIM patients (166 dermatomyositis [DM] and 86 polymyositis [PM] patients) and the 
      association was analyzed with comparison to controls (n = 1026 for DRB1 and 
      n = 413 for DPB1).Results: DRB1*08:03 was associated with IIM (p = 1.60 x 10(-5), 
      pc = .0005, odds ratio [OR] 2.11, 95% confidence interval [CI] 1.52-2.92) and DM 
      (p = .0004, pc = .0128, OR 2.06, 95%CI 1.40-3.02). DPB1*05:01 was also associated 
      with IIM (p = .0001, pc = .0021, OR 1.96, 95%CI 1.38-2.77) and DM (p = .0005, 
      pc = .0075, OR 2.05, 95%CI 1.37-3.08). DRB1*09:01 (p = .0012, pc = .0368, OR 
      0.35, 95% CI 0.18-0.69) and DPB1*04:01(p = .0004, pc = .0057, OR 0.05, 95% CI 
      0.00-0.85) were protectively associated with PM. Two locus analyses suggested 
      that DRB1*09:01 and DPB1*04:01 were independently associated with PM.Conclusion: 
      Protective associations of HLA were detected in Japanese PM patients.
FAU - Furukawa, Hiroshi
AU  - Furukawa H
AD  - Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of 
      Tsukuba, Tsukuba, Japan.
AD  - Clinical Research Center for Allergy and Rheumatology, National Hospital 
      Organization Sagamihara National Hospital, Sagamihara, Japan.
FAU - Oka, Shomi
AU  - Oka S
AD  - Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of 
      Tsukuba, Tsukuba, Japan.
AD  - Clinical Research Center for Allergy and Rheumatology, National Hospital 
      Organization Sagamihara National Hospital, Sagamihara, Japan.
FAU - Kawasaki, Aya
AU  - Kawasaki A
AD  - Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of 
      Tsukuba, Tsukuba, Japan.
FAU - Hidaka, Misaki
AU  - Hidaka M
AD  - Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of 
      Tsukuba, Tsukuba, Japan.
FAU - Shimada, Kota
AU  - Shimada K
AD  - Department of Rheumatology, National Hospital Organization Sagamihara National 
      Hospital, Sagamihara, Japan.
AD  - Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Fuchu, 
      Japan.
FAU - Kondo, Yuya
AU  - Kondo Y
AD  - Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, 
      Tsukuba, Japan.
FAU - Ihata, Atsushi
AU  - Ihata A
AD  - Department of Rheumatology, Yokohama Minami Kyosai Hospital, Yokohama, Japan.
AD  - Department of Rheumatology, National Hospital Organization Yokohama Medical 
      Center, Yokohama, Japan.
FAU - Matsushita, Takashi
AU  - Matsushita T
AD  - Department of Dermatology, Faculty of Medicine, Institute of Medical, 
      Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Matsumoto, Takumi
AU  - Matsumoto T
AD  - Department of Rheumatology, Kin-ikyo Chuo Hospital, Sapporo, Japan.
FAU - Hashimoto, Atsushi
AU  - Hashimoto A
AD  - Department of Rheumatology, National Hospital Organization Sagamihara National 
      Hospital, Sagamihara, Japan.
FAU - Matsumoto, Isao
AU  - Matsumoto I
AD  - Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, 
      Tsukuba, Japan.
FAU - Komiya, Akiko
AU  - Komiya A
AD  - Clinical Research Center for Allergy and Rheumatology, National Hospital 
      Organization Sagamihara National Hospital, Sagamihara, Japan.
AD  - Department of Clinical Laboratory, National Hospital Organization Sagamihara 
      National Hospital, Sagamihara, Japan.
FAU - Kobayashi, Kouji
AU  - Kobayashi K
AD  - Department of Rheumatology, Yokohama Minami Kyosai Hospital, Yokohama, Japan.
FAU - Osada, Atsumu
AU  - Osada A
AD  - Department of Rheumatology, Yokohama Minami Kyosai Hospital, Yokohama, Japan.
FAU - Katayama, Masao
AU  - Katayama M
AD  - Department of Internal Medicine, Nagoya Medical Center, National Hospital 
      Organization, Nagoya, Japan.
FAU - Okamoto, Akira
AU  - Okamoto A
AD  - Department of Rheumatology, Himeji Medical Center, National Hospital 
      Organization, Himeji, Japan.
FAU - Setoguchi, Keigo
AU  - Setoguchi K
AD  - Department of Allergy and Immunological Diseases, Tokyo Metropolitan Cancer and 
      Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
FAU - Kono, Hajime
AU  - Kono H
AD  - Department of Internal Medicine, Teikyo University, Tokyo, Japan.
FAU - Hamaguchi, Yasuhito
AU  - Hamaguchi Y
AD  - Department of Dermatology, Faculty of Medicine, Institute of Medical, 
      Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Matsui, Toshihiro
AU  - Matsui T
AD  - Clinical Research Center for Allergy and Rheumatology, National Hospital 
      Organization Sagamihara National Hospital, Sagamihara, Japan.
AD  - Department of Rheumatology, National Hospital Organization Sagamihara National 
      Hospital, Sagamihara, Japan.
FAU - Fukui, Naoshi
AU  - Fukui N
AD  - Clinical Research Center for Allergy and Rheumatology, National Hospital 
      Organization Sagamihara National Hospital, Sagamihara, Japan.
FAU - Tamura, Hiroaki
AU  - Tamura H
AD  - Department of Rheumatology, Kin-ikyo Chuo Hospital, Sapporo, Japan.
FAU - Takehara, Kazuhiko
AU  - Takehara K
AD  - Department of Dermatology, Faculty of Medicine, Institute of Medical, 
      Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Nagaoka, Shouhei
AU  - Nagaoka S
AD  - Department of Rheumatology, Yokohama Minami Kyosai Hospital, Yokohama, Japan.
FAU - Sugii, Shoji
AU  - Sugii S
AD  - Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Fuchu, 
      Japan.
FAU - Sumida, Takayuki
AU  - Sumida T
AD  - Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, 
      Tsukuba, Japan.
FAU - Tsuchiya, Naoyuki
AU  - Tsuchiya N
AD  - Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of 
      Tsukuba, Tsukuba, Japan.
FAU - Tohma, Shigeto
AU  - Tohma S
AD  - Clinical Research Center for Allergy and Rheumatology, National Hospital 
      Organization Sagamihara National Hospital, Sagamihara, Japan.
AD  - National Hospital Organization Tokyo National Hospital, Kiyose, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190718
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-DP beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Myositis/*genetics
OTO - NOTNLM
OT  - Polymyositis
OT  - dermatomyositis
OT  - human leukocyte antigen
OT  - protective allele
EDAT- 2019/06/28 06:00
MHDA- 2020/11/18 06:00
CRDT- 2019/06/28 06:00
PHST- 2019/06/28 06:00 [pubmed]
PHST- 2020/11/18 06:00 [medline]
PHST- 2019/06/28 06:00 [entrez]
AID - 10.1080/14397595.2019.1637593 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2020 Jul;30(4):696-702. doi: 10.1080/14397595.2019.1637593. Epub 
      2019 Jul 18.