PMID- 31244057
OWN - NLM
STAT- MEDLINE
DCOM- 20200611
LR  - 20221207
IS  - 1948-7193 (Electronic)
IS  - 1948-7193 (Linking)
VI  - 10
IP  - 7
DP  - 2019 Jul 17
TI  - 8-OH-DPAT Induces Compulsive-like Deficit in Spontaneous Alternation Behavior: 
      Reversal by MDMA but Not Citalopram.
PG  - 3094-3100
LID - 10.1021/acschemneuro.8b00593 [doi]
AB  - Rodents exhibit natural exploratory behaviors, which can be measured by the 
      spontaneous alternation behavior (SAB) test. Perseverance in this test induced by 
      the 5-hydroxytryptamine 1A receptor (5-HT(1A)R) agonist, 
      8-hydroxy-2-dipropylaminotetralin (8-OH-DPAT), resembles compulsive behaviors 
      observed in humans and manifests as reduced alternation ratio. This study 
      characterized 8-OH-DPAT-induced perseverance in the SAB test in C57BL/6JOlaHsd 
      male mice by coadministration of WAY100635, citalopram and the 5-HT releasing 
      agent, 3,4-methylenedioxymethamphetamine (MDMA), to deepen the understanding of 
      5-HT-dependent mechanisms. The 5-HT(1A)R mechanism of 8-OH-DPAT (1.0 mg/kg, p < 
      0.01) on perseverance was confirmed by coadministration of the 5-HT(1A)R 
      antagonist, WAY100635 (2.0 mg/kg, p < 0.05), which attenuated the effects of 
      8-OH-DPAT. Such effects could also be reversed by MDMA (1.0 mg/kg, p < 0.05; 10.0 
      mg/kg, p < 0.001) but not citalopram. These findings confirm the importance of 
      5-HT in regulating perseverative behavior. Future investigations are required to 
      determine the predictive validity of the 8-OH-DPAT-disrupted SAB test as an 
      inducible mouse model of compulsivity.
FAU - Odland, Anna U
AU  - Odland AU
AUID- ORCID: 0000-0001-6464-4831
AD  - Department of Drug Design and Pharmacology , University of Copenhagen , 
      Copenhagen 2100 , Denmark.
FAU - Jessen, Lea
AU  - Jessen L
AD  - Department of Drug Design and Pharmacology , University of Copenhagen , 
      Copenhagen 2100 , Denmark.
FAU - Fitzpatrick, Ciaran M
AU  - Fitzpatrick CM
AUID- ORCID: 0000-0002-9996-4541
AD  - Department of Drug Design and Pharmacology , University of Copenhagen , 
      Copenhagen 2100 , Denmark.
AD  - Department of Neuroscience , University of Copenhagen , Copenhagen 2100 , 
      Denmark.
FAU - Andreasen, Jesper T
AU  - Andreasen JT
AD  - Department of Drug Design and Pharmacology , University of Copenhagen , 
      Copenhagen 2100 , Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190617
PL  - United States
TA  - ACS Chem Neurosci
JT  - ACS chemical neuroscience
JID - 101525337
RN  - 0 (Serotonin Agents)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 0DHU5B8D6V (Citalopram)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/*pharmacology
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Citalopram/*pharmacology
MH  - *Compulsive Behavior
MH  - Dose-Response Relationship, Drug
MH  - Exploratory Behavior/*drug effects
MH  - Male
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Serotonin Agents/pharmacology
MH  - Serotonin Receptor Agonists/pharmacology
MH  - Selective Serotonin Reuptake Inhibitors/pharmacology
OTO - NOTNLM
OT  - 5-HT receptor agonist
OT  - 5-hydroxytryptamine
OT  - MDMA
OT  - citalopram
OT  - compulsivity
OT  - spontaneous alternation behavior
EDAT- 2019/06/28 06:00
MHDA- 2020/06/12 06:00
CRDT- 2019/06/28 06:00
PHST- 2019/06/28 06:00 [pubmed]
PHST- 2020/06/12 06:00 [medline]
PHST- 2019/06/28 06:00 [entrez]
AID - 10.1021/acschemneuro.8b00593 [doi]
PST - ppublish
SO  - ACS Chem Neurosci. 2019 Jul 17;10(7):3094-3100. doi: 
      10.1021/acschemneuro.8b00593. Epub 2019 Jun 17.